Selective D-1 dopamine receptor agonist treatment of parkinson's disease

Braun, Allen R.; Fabbrini, Giovanni; Mouradian, M. Maral; Serrati, Carlo; Barone, Paolo; Chase, Thomas N.

doi:10.1007/bf01244638

Cited by 127 publications

(46 citation statements)

References 31 publications

(17 reference statements)

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“…However, since its behavioural effects were distinct from both those of SCH 23390 and ractopride in not inducing catalepsy, such explanations appear less likely. Certainly in man SKF 38393 does not produce the antiparkinsonian activity that its D-1 agonist effect in rodents would suggest (Braun et al 1987). The uncertainty over SKF 38393 can only be resolved when further selective D-1 agonists become available.…”

Section: Discussionmentioning

confidence: 99%

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to normal common marmosets

Löschmann¹,

Smith

Lange

et al. 1991

Psychopharmacology

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Abstract.In normal common marmosets administration of the D-1/D-2 agonist apomorphine or the selective D-2 agonist quinpirole caused a dose-dependent increase in motor activity and induced stereotyped behaviour. Both the selective D-2 antagonist raclopride and the selective D-I antagonist SCH 23390 inhibited normal locomotor activity and induced catalepsy. Quinpirole-and apomorphine-induced motor activity were potently inhibited by pretreatment with raclopride. The effects of quinpirole, but not apomorphine, were weakly inhibited by SCH 23390. The selective D-1 partial agonist SKF 38393 decreased motor activity and did not induce grooming, oral movements or other behaviours. SKF 38393 inhibited motor activity induced by the administration of quinpirole but did not alter apomorphine-induced motor behaviour. Locomotor activity in normal common marmosets appears to be mediated mainly via D-2 systems. In contrast to rodents, administration of SKF 38393 does not induce behavioural activation and there does not appear to be a facilitating effect of D-1 systems on D-2 function in the normal common marmoset. However, the ability of both SKF 38393 and SCH 23390 to inhibit quinpirole locomotor activity suggests some interaction between D-1 and D-2 systems to occur in this species.

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Section: Discussionmentioning

confidence: 99%

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to normal common marmosets

Löschmann¹,

Smith

Lange

et al. 1991

Psychopharmacology

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“…Under oral administration, both the D1/D5 agonist SKF 38393 and antagonist SKF 83566 are rapidly absorbed and penetrate the blood-brain barrier. Indeed, the agonist is used clinically for the treatment of Parkinson's disease and nicotine craving (Braun et al 1987;Nakagome et al 2011).…”

Section: D1/d5 Receptors Mediate the Priming Effect Of Nicotine In Thmentioning

confidence: 99%

D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus

et al. 2014

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The dentate gyrus (DG) of the hippocampus is critical for spatial memory and is also thought to be involved in the formation of drug-related associative memory. Here, we attempt to test an aspect of the Gateway Hypothesis, by studying the effect of consecutive exposure to nicotine and cocaine on long-term synaptic potentiation (LTP) in the DG. We find that a single injection of cocaine does not alter LTP. However, pretreatment with nicotine followed by a single injection of cocaine causes a substantial enhancement of LTP. This priming effect of nicotine is unidirectional: There is no enhancement of LTP if cocaine is administrated prior to nicotine. The facilitation induced by nicotine and cocaine can be blocked by oral administration of the dopamine D1/D5 receptor antagonist (SKF 83566) and enhanced by the D1/D5 agonist (SKF 38393). Application of the histone deacetylation inhibitor suberoylanilide hydroxamic acid (SAHA) simulates the priming effect of nicotine on cocaine. By contrast, the priming effect of nicotine on cocaine is blocked in genetically modified mice that are haploinsufficient for the CREB-binding protein (CBP) and possess only one functional CBP allele and therefore exhibit a reduction in histone acetylation. These results demonstrate that the DG of the hippocampus is an important brain region contributing to the priming effect of nicotine on cocaine. Moreover, both activation of dopamine-D1 receptor/ PKA signaling pathway and histone deacetylation/CBP mediated transcription are required for the nicotine priming effect in the DG.

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“…However, it is the primate model which appears predictive of drug action in man since SKF 38393 did not improve motor symptoms in Parkinson's disease when administered alone or in conjunction with L-dopa (Braun et al 1987).…”

Section: Effects Of Quinpirole or Apomorphine In Combination With Skfmentioning

confidence: 99%

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets

Löschmann¹,

Smith

Lange

et al. 1992

Psychopharmacology

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Abstract.The ability of selective D-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in MPTP-treated common marmosets. Both the D-2 agonist quinpirole and the mixed D-l/D-2 agonist apomorphine reversed the motor impairments and induced locomotor activity. The D-I antagonist SCH 23390 and the D-2 antagonist raclopride given alone further reduced motor function in MPTP-treated animals. The actions of quinpirote were potently and completely inhibited by raclopride but only partially and inconsistently by SCH 23390. In contrast, the effects of apomorphine were markedly but incompletely inhibited by both raclopride and SCH 23390. The D-1 agonist SKF 38393 alone caused a dose related reduction in motor activity. SKF 38393 weakly and partially inhibited the improvements in motor function produced by quinpirole but had a more pronounced effect on apomorphine induced motor actiw ity. The induction of motor activity in MPTP treated common marmosets may separately involve both D-1 and D-2 receptors. Comparison with our previous data on the effect of the same drugs in normal common marmosets provides some evidence for a breakdown of linkage between D-t and D-2 systems following MPTP treatment. The actions of SKF 38393 in MPTP-treated common marmosets contrasts with its ability to induce behavioural activation and a facilitation of D-2 mediated behaviour in rodents. SKF 38393 may not be the compound with which to delineate the role of D-1 receptors in primates.

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Selective D-1 dopamine receptor agonist treatment of parkinson's disease

Cited by 127 publications

References 31 publications

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to normal common marmosets

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to normal common marmosets

D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets

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