Arch Dermatol
 1963
DOI: 10.1001/archderm.1963.01590210005001
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

Selective Cytotoxic Effect of Topical 5-Fluorouracil

Calvin J. Dillaha1
Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
137
3
2
0

Citation Types

0
11
0
0

Year Published

1965
1965
2025
2025

Publication Types

Select...
125
14
2

Relationship

0
141

Authors

Journals

citations

Cited by 141 publications

(11 citation statements)
references

References 7 publications

0
11
0
0
Order By: Relevance
“…But will the virtues of 5‐aminolevulinic acid photodynamic therapy stand the test of time? Similar excitement was experienced years ago when 5‐fluorouracil applied topically was found to selectively eliminate atypical cells in the epidermis whether or not one could distinguish a clinical lesion 2 . Then just like with photodynamic therapy, different types of precancers and cancers were soon being treated with topical 5‐fluorouracil 3,4 .…”
Section: Commentarymentioning
confidence: 80%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…But will the virtues of 5‐aminolevulinic acid photodynamic therapy stand the test of time? Similar excitement was experienced years ago when 5‐fluorouracil applied topically was found to selectively eliminate atypical cells in the epidermis whether or not one could distinguish a clinical lesion 2 . Then just like with photodynamic therapy, different types of precancers and cancers were soon being treated with topical 5‐fluorouracil 3,4 .…”
Section: Commentarymentioning
confidence: 80%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Moreover, capecitabine, doxorubicin, cyclophosphamide, and especially 5‐FU could cause hyperpigmentation in other places such as tongue, palm, and soles besides the injection site through the upregulating the activity of melanocyte‐stimulating hormone [61]. Although topical 5‐FU is applied in the treatment of vitiligo through its antimitotic activity, usage of this drug systematically could make hyperpigmentation on extremities and tongue [62–64]. When 5‐FU are used systematically, it destroys keratinocytes and proliferates melanocytes.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Topical 5-fluorouracil is associated with the following cutaneous adverse effects: allergic contact dermatitis, conjunctivitis, corneal irritation, erosions, hyperpigmentation, hypopigmentation, irritant dermatitis, onycholysis, photosensitivity, and secondary bacterial infections [ 9 – 11 ]. There are also several reports of individuals with a prior history of facial seborrheic dermatitis or rosacea experiencing a flare of their dermatosis after application of 5-fluorouracil to their face [ 12 – 14 ].…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo