Selective Cytotoxic Effect of Topical 5-Fluorouracil

Dillaha, Calvin J.; Jansen, G. Thomas; Honeycutt, W M; Bradford, A C

doi:10.1001/archderm.1963.01590210005001

Cited by 130 publications

(10 citation statements)

References 7 publications

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“…Due to its antimitotic activity, it is easy to understand that topical 5-FU is a useful therapy for the treatment of many dermatological disorders characterized by a high mitotic rate (e.g., nonmelanoma skin cancers, actinic keratosis, benign tumours, nail psoriasis, and porokeratosis) [10–12]. In the same way, it is expected that 5-FU applied to a wound will strongly inhibit wound epithelialization and, consequently, will delay the wound healing [13], so it is surprising that 5-Fu would be implicated in the vitiligo repigmentation process which obviously needs melanocyte proliferation.…”

Section: Introductionmentioning

confidence: 99%

Possible Mechanisms by Which Topical 5-Fluorouracil and Dermabrasion Could Induce Pigment Spread in Vitiligo Skin: An Experimental Study

et al. 2013

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The combination of skin ablation and 5-Fluorouracil (5-FU) ointment was previously tried in the treatment of vitiligo, and good results were specifically reported in glabrous skin without follicular melanocyte reservoirs. Methods. This study was carried out on the skins of seven guinea pigs: three were treated with mechanical dermabrasion plus topical 5-FU in an achromic area contiguous to a pigmented area; two were treated by only dermabrasion in a similar area; and two were treated by topical 5-FU alone. Clinical, histological, and ultrastructural studies were performed over two months. Results. In guinea pigs treated with dermabrasion plus 5-FU, we observed firstly a delay of wound healing with an obvious inflammatory reaction, and, after two months, evident pigment spread from the pigmented into the achromic area. After six months, we noticed black hair regrowing in the achromic area. Pigment spread was not seen in the guinea pigs skin treated by either dermabrasion or topical 5-FU. We suggest that the inflammatory mediators and enzymes (metalloproteinases), which are locally released over a long time, could stimulate and facilitate melanocyte proliferation and migration through the enlarged intercellular spaces of the epidermis. This sequence of events may be applied to vitiligo patients treated with 5-FU on ablated lesions.

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Section: Introductionmentioning

confidence: 99%

Possible Mechanisms by Which Topical 5-Fluorouracil and Dermabrasion Could Induce Pigment Spread in Vitiligo Skin: An Experimental Study

et al. 2013

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“…The Mohs chemosurgical technique has also been reported to have a high cure rate 15,16 . More recently, therapy with topical 5FU cream has been advocated for the treatment of EQ, with favorable results 3–8 . This has been preferred because of its ability to selectively destroy tumor cells without significant damage to adjacent normal tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Although EQ has been expanded to involve CIS of all mucosal structures of men and women, Graham recommends the strict limitation of this concept to the male genitalia 3 . The high recurrence rate as well as the potentially mutilating effects of conventional treatment had led investigators to use topical 5‐fluorouracil (5FU) in an attempt to conservatively ablate this potentially invasive form of CIS 4–6 . Subsequent reports have confirmed the effectiveness of this modality for the treatment of EQ 7,8 …”

mentioning

confidence: 99%

Carcinoma In Situ of the Glans Penis and Distal Urethra

Bernstein¹,

Forgaard²,

Miller³

1986

The Journal of Dermatologic Surgery and Oncology

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“…Topical FU can be extemporaneously prepared by the pharmacist on prescription, and such a preparation has a number of advantages which would recommend its routine use. In the approximately five years from the time topical FU was first introduced as an effective therapy for multiple actinic keratoses by Dillaha et al (5) until it became commercially procurable, only extemporaneous preparations were available. Those of us who early embraced this form of therapy gained familiarity with it and knowledge of expected reactions; accordingly we continued to use it after commercial preparations became available.…”

Section: Methods Of Utilization Of Topical Fluorouracilmentioning

confidence: 99%

Topical Fluorouracil Therapy for Precancers and Cancers of the Skin

Cullen

1979

J American Geriatrics Society

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Topical fluorouracil (FU) is an extremely effective agent for treating multiple actinic keratoses. It is also of value in the treatment of Bowen's disease, actinic cheilitis, arsenical keratoses, radiodermatitis, X‐ray‐induced keratoses, leukoplakia, and the erythroplasia of Queyrat. Topical FU may be successful in the treatment of superficial basal‐cell carcinomas, but should not be used for nodular carcinomas of the face or neck except under unusual circumstances and with mandatory histologic follow‐up evaluation. The usual method of treatment is twice daily application of a 1 percent FU solution in propylene glycol. Several modifications of various types of commonly employed preparations and the manner in which each is used are described, along with the respective indications. The considerable discomfort associated with the use of topical FU can be lessened by the stepwise approach outlined—a method extraordinarily valuable for older patients. Occasional complications are primary irritant dermatitis and allergic contact dermatitis; these must be recognized promptly and treated, as must other less frequent side effects. Topical FU appears to be of great value in the destruction of existing precancerous skin lesions. When used repeatedly, it may postpone indefinitely the development of significant precancerous and cancerous skin lesions.

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Selective Cytotoxic Effect of Topical 5-Fluorouracil

Cited by 130 publications

References 7 publications

Possible Mechanisms by Which Topical 5-Fluorouracil and Dermabrasion Could Induce Pigment Spread in Vitiligo Skin: An Experimental Study

Possible Mechanisms by Which Topical 5-Fluorouracil and Dermabrasion Could Induce Pigment Spread in Vitiligo Skin: An Experimental Study

Carcinoma In Situ of the Glans Penis and Distal Urethra

Topical Fluorouracil Therapy for Precancers and Cancers of the Skin

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