Selective construction of polycyclic cyclohepta[b]indoles and cyclopenta[b]indoles via cycloaddition reaction of 3-(indol-3-yl)maleimides and (indol-2-yl)methanols

Abstract

p-TsOH promoted annulation reaction of 3-(indol-3-yl)maleimides and (indol-2-yl)diphenylmethanols in chloroform afforded functionalized pyrrolo[3',4':6,7]cyclohepta[1,2-b:4,5-b']diindoles in satisfactory yields, in which a formal [4+3] cycloaddition and an unprecedented rearrangement of maleimide motif from...

A Historical Perspective on the Management of Facial Paralysis

“…In ancient China, Radix Gentianae Macrophyllae, commonly known as Qinjiao in China, is a dried root that was used for the treatment of various diseases such as arthritis, stroke, facial paralysis, and scapulohumeral periarthritis for thousands of years 13 . Current Chinese researchers have found evidence of the treatment of FNP in ancient acupuncture therapies of the face and neck 14 . Xiaoxuming Decoction was an ancient herbal formulae that was used for the treatment of stroke in China before the start of the Han and Tang dynasties (200–900 AD).…”

Chemodivergent (4 + 3) cycloadditions of 2-indolylmethanols with 1,3,5-triazinanes: access to polycyclic indoles

“…[32][33][34][35][36][37] Additionally, carbocation B can exhibit normal C3 nucleophilicity when reacting with an electrophilic dipolarophile. [38][39][40][41][42][43] In these elegant achievements, 2-indolylmethanols were commonly utilized as three-atom (3A) synthons driven by the departure of the OH group. 44,45 The (4 + n) cycloadditions of 2-indolylmethanols wherein all atoms are effective, however, are considered highly challenging.…”