Selective Colour Vision Deficits in Multiple Sclerosis at Different Temporal Stages

Anssari, Neda; Vosoughi, Reza; Mullen, Kathy T.; Mansouri, Behzad

doi:10.1080/01658107.2019.1615960

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…Most importantly, blue hue discrimination deficiency has been found more frequently in the early stages of AD 49,59,65,67 or could be independent of AD severity 66 , which corroborates our finding of early and stable lower B ↔ W transitions in all three age groups of AD + mice. Blue color discrimination impairment was also reported in patients with neurodegenerative disorders such as multiple sclerosis, Parkinson's disease, Huntington's disease and Gilles de la Tourette syndrome [124][125][126][127][128][129] . Though not specific to AD, our data support the relevance of (f-g) Percentage of entries in the arm containing the black object (f) and the clear object (g).…”

Section: Discussionmentioning

confidence: 85%

Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze

Vit

Fuchs

Angel

et al. 2021

Sci Rep

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We introduce a novel visual-stimuli four-arm maze (ViS4M) equipped with spectrally- and intensity-controlled LED emitters and dynamic grayscale objects that relies on innate exploratory behavior to assess color and contrast vision in mice. Its application to detect visual impairments during normal aging and over the course of Alzheimer’s disease (AD) is evaluated in wild-type (WT) and transgenic APPSWE/PS1∆E9 murine models of AD (AD+) across an array of irradiance, chromaticity, and contrast conditions. Substantial color and contrast-mode alternation deficits appear in AD+ mice at an age when hippocampal-based memory and learning is still intact. Profiling of timespan, entries and transition patterns between the different arms uncovers variable AD-associated impairments in contrast sensitivity and color discrimination, reminiscent of tritanomalous defects documented in AD patients. Transition deficits are found in aged WT mice in the absence of alternation decline. Overall, ViS4M is a versatile, controlled device to measure color and contrast-related vision in aged and diseased mice.

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Section: Discussionmentioning

confidence: 85%

Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze

Vit

Fuchs

Angel

et al. 2021

Sci Rep

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“…In light of the new results presented here, the role of the M-cone pathway in dyschromatopsia deserves to be examined in patients with autoimmune demyelination by recording chromatic ERGs. Such recording may even be useful for monitoring subclinical disease progression, as dyschromatopsia can be observed in absence of optic neuritis [ 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

B cell-dependent EAE induces visual deficits in the mouse with similarities to human autoimmune demyelinating diseases

Joly

Mdzomba

Rodriguez

et al. 2022

J Neuroinflammation

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Background In the field of autoimmune demyelinating diseases, visual impairments have extensively been studied using the experimental autoimmune encephalomyelitis (EAE) mouse model, which is classically induced by immunization with myelin oligodendrocyte glycoprotein peptide (MOG35–55). However, this model does not involve B cells like its human analogs. New antigens have thus been developed to induce a B cell-dependent form of EAE that better mimics human diseases. Methods The present study aimed to characterize the visual symptoms of EAE induced with such an antigen called bMOG. After the induction of EAE with bMOG in C57BL/6J mice, visual function changes were studied by electroretinography and optomotor acuity tests. Motor deficits were assessed in parallel with a standard clinical scoring method. Histological examinations and Western blot analyses allowed to follow retinal neuron survival, gliosis, microglia activation, opsin photopigment expression in photoreceptors and optic nerve demyelination. Disease effects on retinal gene expression were established by RNA sequencing. Results We observed that bMOG EAE mice exhibited persistent loss of visual acuity, despite partial recovery of electroretinogram and motor functions. This loss was likely due to retinal inflammation, gliosis and synaptic impairments, as evidenced by histological and transcriptomic data. Further analysis suggests that the M-cone photoreceptor pathway was also affected. Conclusion Therefore, by documenting visual changes induced by bMOG and showing similarities to those seen in diseases such as multiple sclerosis and neuromyelitis optica, this study offers a new approach to test protective or restorative ophthalmic treatments.

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“…AD patients are reported to experience altered color vision with a selective and severity-independent deficiency in blue hue discrimination (Cronin-Golomb et al, 1993;Wijk et al, 1999;Rizzo et al, 2000;Chang et al, 2014;Polo et al, 2017). Interestingly, impaired blue color discrimination also manifests in patients with other neurodegenerative disorders (Paulus et al, 1993;Haug et al, 1995;Birch et al, 1998;Rodnitzky, 1998;Melun et al, 2001;Anssari et al, 2020).…”

Section: Functional and Visual Changes In Alzheimer's Diseasementioning

confidence: 99%

Alzheimer’s Retinopathy: Seeing Disease in the Eyes

et al. 2020

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The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD) pathology. As a CNS extension of the brain, the neuro retina is easily accessible for noninvasive, high-resolution imaging. Studies have shown that along with cognitive decline, patients with mild cognitive impairment (MCI) and AD often suffer from visual impairments, abnormal electroretinogram patterns, and circadian rhythm disturbances that can, at least in part, be attributed to retinal damage. Over a decade ago, our group identified the main pathological hallmark of AD, amyloid β-protein (Aβ) plaques, in the retina of patients including early-stage clinical cases. Subsequent histological, biochemical and in vivo retinal imaging studies in animal models and in humans corroborated these findings and further revealed other signs of AD neuropathology in the retina. Among these signs, hyperphosphorylated tau, neuronal degeneration, retinal thinning, vascular abnormalities and gliosis were documented. Further, linear correlations between the severity of retinal and brain Aβ concentrations and plaque pathology were described. More recently, extensive retinal pericyte loss along with vascular platelet-derived growth factor receptor-β deficiency were discovered in postmortem retinas of MCI and AD patients. This progressive loss was closely associated with increased retinal vascular amyloidosis and predicted cerebral amyloid angiopathy scores. These studies brought excitement to the field of retinal exploration in AD. Indeed, many questions still remain open, such as queries related to the temporal progression of AD-related pathology in the retina compared to the brain, the relations between retinal and cerebral changes and whether retinal signs can predict cognitive decline. The extent to which AD affects the retina, including the susceptibility of certain topographical regions and cell types, is currently under intense investigation. Advances in retinal amyloid imaging, hyperspectral imaging, optical coherence tomography, and OCT-angiography encourage the use of such modalities to achieve more accurate, patient-and user-friendly, noninvasive detection and monitoring of AD. In this review, we summarize the current status in the field while addressing the many unknowns regarding Alzheimer's retinopathy.

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Selective Colour Vision Deficits in Multiple Sclerosis at Different Temporal Stages

Cited by 7 publications

References 28 publications

Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze

Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze

B cell-dependent EAE induces visual deficits in the mouse with similarities to human autoimmune demyelinating diseases

Alzheimer’s Retinopathy: Seeing Disease in the Eyes

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