Selective Cleavage of Isopropyl Aryl Ethers by Aluminum Trichloride^†

Total synthesis of propolisbenzofuran B

“…Removal of the silyl ether with 20% HF and acetylation of the resulting primary alcohol proceeded smoothly and set the stage for selective deprotection of the isopropyl ethers with AlCl 32 3. These three steps proceeded in 77% yield overall and gave synthetic propolisbenzofuran B ( 1 ) that displayed identical spectral data to that reported for the natural product (IR, 1 H, 13 C, MS).…”

Gaining diversity in solid-phase synthesis by modulation of cleavage conditions from hydroxymethyl-based supports. Application to lamellarin synthesis

“…The hydroxyl group of the OH in position 3 was protected as isopropyl ether, which can be cleaved by acids, 20 if it is desired. Other MeO groups were already introduced into the building blocks.…”

Synthesis of a Tubulin Assembly Inhibitors OXi8006

“…且已有 多篇文章及相关专利对其磷酸盐前药(OXi8007)进行报 道, OXi8007 能够选择性抑制多种人类癌细胞株, 具有 良好的抗癌活性(例如, GI 50 ＝36 nmol/L, 前列腺癌细 胞) [2] . 150.8, 147.0, 136.6, 128.0, 122.3, 115.6, 111.6, 87.3, 71.7, 56.1, 22 [7] . ) [8] .…”