“…Therefore, our focus was to synthesize a simple, water-soluble, interference-free Schiff base probe that could sense both metal ions and anions in a physiological medium as a continuation of our research probes for the detection of different analytes. 41,42 Herein, we have designed and synthesized a simple chromone derivative-based multi-selective chemical probe L (Scheme 1), which was utilized for the selective ''turn-on'' detection of Al 3+ in an aqueous medium at physiological pH. The probe-Al 3+ ensemble could be employed as a fluorescence ''turn off'' sensor for PP i among all other common anions under the same experimental condition.…”