Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease

Gentili, M; Ronchetti, Simona; Paola, Rosanna Di; Gugliandolo, Enrico; Cuzzocrea, Salvatore; Bereshchenko, Oxana; Migliorati, Graziella; Riccardi, Carlo

doi:10.1016/j.phrs.2018.12.005

Cited by 31 publications

(22 citation statements)

References 63 publications

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“…Agonists of CB2 have been shown to inhibit TNF-α from CD14 + monocytes and M1 macrophages, and increase expression of anti-inflammatory cytokine IL-10 [37]. CB2 agonists also induce anti-inflammatory FoxP3 + regulatory T-cells (Tregs) which produce TGF-β and IL-10 [39]. In addition, CBD has been shown to induce the differentiation of functional immunosupressive Tregs [40].…”

Section: Cannabidiol To Decrease Sars-cov-2 Associated Inflammationmentioning

confidence: 99%

Acute inflammation and pathogenesis of SARS-CoV-2 infection: Cannabidiol as a potential anti-inflammatory treatment?

Costiniuk

Jenabian

2020

Cytokine & Growth Factor Reviews

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Section: Cannabidiol To Decrease Sars-cov-2 Associated Inflammationmentioning

confidence: 99%

Acute inflammation and pathogenesis of SARS-CoV-2 infection: Cannabidiol as a potential anti-inflammatory treatment?

Costiniuk

Jenabian

2020

Cytokine & Growth Factor Reviews

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“…was shown this compound promoted the differentiation of Th0 cells into Tregs by inducing FoxP3, TGF-β, and IL-10 [86]. In this study, the authors used DNBS-induced colitis and showed that JTE907 treatment induced CD4 + CD25 + FoxP3 + cells in the lamina propria, which was associated with attenuation of colitis [86].…”

Section: Epigenetics Pathways Of Cannabinoid-mediated Suppression Of Inflammationmentioning

confidence: 77%

Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases

Holloman

Nagarkatti

2021

IJMS

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Chronic inflammation is considered to be a silent killer because it is the underlying cause of a wide range of clinical disorders, from cardiovascular to neurological diseases, and from cancer to obesity. In addition, there are over 80 different types of debilitating autoimmune diseases for which there are no cure. Currently, the drugs that are available to suppress chronic inflammation are either ineffective or overtly suppress the inflammation, thereby causing increased susceptibility to infections and cancer. Thus, the development of a new class of drugs that can suppress chronic inflammation is imperative. Cannabinoids are a group of compounds produced in the body (endocannabinoids) or found in cannabis (phytocannabinoids) that act through cannabinoid receptors and various other receptors expressed widely in the brain and immune system. In the last decade, cannabinoids have been well established experimentally to mediate anti-inflammatory properties. Research has shown that they suppress inflammation through multiple pathways, including apoptosis and inducing immunosuppressive T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Interestingly, cannabinoids also mediate epigenetic alterations in genes that regulate inflammation. In the current review, we highlight how the epigenetic modulations caused by cannabinoids lead to the suppression of inflammation and help identify novel pathways that can be used to target autoimmune diseases.

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“…Some of the most established data on the endocannabinoid system’s immune related roles and the effects of phyto- and synthetic- cannabinoids on immunity, come from pre-clinical studies of autoimmune diseases [ 20 , 89 ]. Several groups have shown that cannabinoids can influence the balance between inflammatory Th17 and regulatory T-cells [ 33 , 90 , 91 ], inducing a regulatory phenotype. The clinical effects of cannabinoid-based treatments were studied in several inflammatory, autoimmune related diseases.…”

Section: The Effects Of Cannabinoid-based Treatments In Different mentioning

confidence: 99%

Cannabis, the Endocannabinoid System and Immunity—the Journey from the Bedside to the Bench and Back

Almogi-Hazan

2020

IJMS

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The Cannabis plant contains numerous components, including cannabinoids and other active molecules. The phyto-cannabinoid activity is mediated by the endocannabinoid system. Cannabinoids affect the nervous system and play significant roles in the regulation of the immune system. While Cannabis is not yet registered as a drug, the potential of cannabinoid-based medicines for the treatment of various conditions has led many countries to authorize their clinical use. However, the data from basic and medical research dedicated to medical Cannabis is currently limited. A variety of pathological conditions involve dysregulation of the immune system. For example, in cancer, immune surveillance and cancer immuno-editing result in immune tolerance. On the other hand, in autoimmune diseases increased immune activity causes tissue damage. Immuno-modulating therapies can regulate the immune system and therefore the immune-regulatory properties of cannabinoids, suggest their use in the therapy of immune related disorders. In this contemporary review, we discuss the roles of the endocannabinoid system in immunity and explore the emerging data about the effects of cannabinoids on the immune response in different pathologies. In addition, we discuss the complexities of using cannabinoid-based treatments in each of these conditions.

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Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease

Cited by 31 publications

References 63 publications

Acute inflammation and pathogenesis of SARS-CoV-2 infection: Cannabidiol as a potential anti-inflammatory treatment?

Acute inflammation and pathogenesis of SARS-CoV-2 infection: Cannabidiol as a potential anti-inflammatory treatment?

Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases

Cannabis, the Endocannabinoid System and Immunity—the Journey from the Bedside to the Bench and Back

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