Selective catecholamine detection in living cells by a copper-mediated oxidative bond cleavage

Abstract

A copper-mediated oxidative bond cleavage induced by catecholamines is developed into a turn-on fluorescent probe for imaging of the neurotransmitter in living cells.

Ligand-Based Shielding Effect Induced Efficient Near-Infrared Electrochemiluminescence of Gold Nanoclusters and Its Sensing Application

“…Noradrenaline (NE) is a sort of crucial biogenic neurotransmitter in the human body, and its dysregulation is tightly involved in various neurodegenerative diseases, such as Alzheimer's, Parkinson's, pheochromocytoma, etc., whose level is crucial for monitoring and diagnosing diseases. 43,44 Moreover, noradrenaline is currently the most commonly used vasopressor agent in clinical applications for treating septic shock, cardiogenic shock, and hypovolemic shock; thus, the injected dose influences the drug effects. 45,46 Therefore, the detection of noradrenaline possesses important significance for clinical diagnosis and pharmaceutical quantification.…”

Hetarenocoumarins based on 7-hydroxy-3-(benzothiazol-2-yl)coumarin

“…catecholamine [8], Cu 2+ [9], for sequential recognition of Ni 2+ and CN - [10], hydrazine [11], superoxides [12], palladium [13], and hydrogen peroxide [14]. Many probes were synthesized based on 7-hydroxy-3benzothiazolylcoumarin, which itself can serve as a laser dye [15].…”

Coreactant-free polyfluorene nanoparticles for the electrochemiluminescence quantitative analysis of dopamine and norepinephrine

“…The dysregulation of DA and NE is implicated in a variety of neurodegenerative diseases such as Schizophrenia, Parkinson's disease, attention deficit hyperactivity disorder and depression. [1][2][3] Therefore, their accurate detection is of great clinical value. The reported detection methods mainly include fluorescence, 4,5 electrochemistry, 6,7 colorimetry, 8 and mass spectrometry.…”