Selective breeding of rats for high (HAB) and low (LAB) anxiety-related behaviour: A unique model for comorbid depression and social dysfunctions

Gryksa, Katharina; Schmidtner, Anna K; Masís-Calvo, Marianella; Rodríguez-Villagra, Odir Antonio; Havasi, Andrea; Wirobski, Gwendolyn; Maloumby, Rodrigue; Jägle, Herbert; Bosch, Oliver J.; Slattery, David A.; Neumann, Inga D.

doi:10.1016/j.neubiorev.2023.105292

Cited by 3 publications

(2 citation statements)

References 305 publications

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“…Based on the sensitivity to stress, animals with a higher sensitivity to stress response are selected for breeding. 30 Based on the assumption that the 5‐HT system is dysfunctional in anxiety disorders, mice lacking the gene that codes for the serotonin transporter and 5‐HT1A receptors exhibit increased anxiety‐like behaviors due to impaired serotonin reuptake. 31 , 32 Meanwhile, mice with genetic deletion of GABAAR or GABABR increase anxiety‐like behaviors due to reduced neuronal inhibition.…”

Section: Current Animal Models Of Anxietymentioning

confidence: 99%

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Zhao,

Zhou,

Liu

et al. 2023

Anim Models and Exp Med

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Anxiety disorders have become one of the most severe psychiatric disorders, and the incidence is increasing every year. They impose an extraordinary personal and socioeconomic burden. Anxiety disorders are influenced by multiple complex and interacting genetic, psychological, social, and environmental factors, which contribute to disruption or imbalance in homeostasis and eventually cause pathologic anxiety. The selection of a suitable animal model is important for the exploration of disease etiology and pathophysiology, and the development of new drugs. Therefore, a more comprehensive understanding of the advantages and limitations of existing animal models of anxiety disorders is helpful to further study the underlying pathological mechanisms of the disease. This review summarizes animal models and the pathogenesis of anxiety disorders, and discusses the current research status to provide insights for further study of anxiety disorders.

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Section: Current Animal Models Of Anxietymentioning

confidence: 99%

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Zhao,

Zhou,

Liu

et al. 2023

Anim Models and Exp Med

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show abstract

“…The animal models required for understanding the physio logical, genetic and epigenetic mechanisms regulating evolu tionarily fixed phenotypic traits of an organism are supposed to perfectly mimic the symptoms of the pathology being studied and to conform to strict criteria (Gryksa et al, 2023). The most popular animal models are rats and mice, with do zens of thousands of laboratory strains in use (Gayday E.A., Gayday D.S., 2019).…”

Section: Introductionmentioning

confidence: 99%

RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research

Chadaeva,

Filonov,

Zolotareva

et al. 2023

Vestn. VOGiS

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The animal models used in biomedical research cover virtually every human disease. RatDEGdb, a knowledge base of the differentially expressed genes (DEGs) of the rat as a model object in biomedical research is a collection of published data on gene expression in rat strains simulating arterial hypertension, age-related diseases, psychopathological conditions and other human afflictions. The current release contains information on 25,101 DEGs representing 14,320 unique rat genes that change transcription levels in 21 tissues of 10 genetic rat strains used as models of 11 human diseases based on 45 original scientific papers. RatDEGdb is novel in that, unlike any other biomedical database, it offers the manually curated annotations of DEGs in model rats with the use of independent clinical data on equal changes in the expression of homologous genes revealed in people with pathologies. The rat DEGs put in RatDEGdb were annotated with equal changes in the expression of their human homologs in affected people. In its current release, RatDEGdb contains 94,873 such annotations for 321 human genes in 836 diseases based on 959 original scientific papers found in the current PubMed. RatDEGdb may be interesting first of all to human geneticists, molecular biologists, clinical physicians, genetic advisors as well as experts in biopharmaceutics, bioinformatics and personalized genomics. RatDEGdb is publicly available at https://www.sysbio.ru/RatDEGdb.

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Repetitive transcranial magnetic stimulation (rTMS) for depressive-like symptoms in rodent animal models

Zoicas,

Licht,

Mühle

et al. 2024

Neuroscience & Biobehavioral Reviews

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Selective breeding of rats for high (HAB) and low (LAB) anxiety-related behaviour: A unique model for comorbid depression and social dysfunctions

Cited by 3 publications

References 305 publications

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research

Repetitive transcranial magnetic stimulation (rTMS) for depressive-like symptoms in rodent animal models

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