Selective breeding of high and Low antibody-responder lines of guinea pigs

Ibañez, Olga M.; Reis, Moema S.; Gennari, Marisa; Ferreira, Vera C. A.; Sant’Anna, Osvaldo A.; Siqueira, Maria; Biozzi, G

doi:10.1007/bf01561576

Cited by 10 publications

(4 citation statements)

References 4 publications

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“…Responses to divergent selection for antibody production to erythrocyte antigens have been demonstrated in mice (Biozzi et al, 1982), guinea pigs (Ibanez et al, 1980), and chickens (Siegel et al, 1982). Such selection has resulted in correlated responses in resistance to infectious agents, growth, and reproductive traits (Biozzi et al, 1982;Siegel et al, 1982).…”

Section: Introductionmentioning

confidence: 94%

Allelic Frequencies in Eight Alloantigen Systems of Chickens Selected for High and Low Antibody Response to Sheep Red Blood Cells

Dunnington

Briles

et al. 1984

Poultry Science

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Parents and offspring from lines of chickens selected for high (HA) and low (LA) antibody response to sheep red blood cell antigen(s) were blood typed for systems A, B, C, D, E, H, I, and L. All birds were homozygous for allele L2, and allelic frequencies for the I system were essentially identical in both lines. In contrast, allelic frequencies of the other blood group systems differed rather markedly between the HA and LA lines.

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Section: Introductionmentioning

confidence: 94%

Allelic Frequencies in Eight Alloantigen Systems of Chickens Selected for High and Low Antibody Response to Sheep Red Blood Cells

Dunnington

Briles

et al. 1984

Poultry Science

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“…Genetic variation for antibody response to sheep erythrocytes has been demonstrated in several species, including mice (Biozzi et al, 1970), guinea pigs (Ibanez et al, 1980), and chickens van der Zijpp et al, 1983). With chickens, selection for high and low antibody production to sheep erythrocytes resulted in correlated responses for the following: growth and reproductive traits (Siegel et al, 1982;van der Zijpp et al, 1988); gene frequencies at alloantigen loci van der Zijpp et al, 1987); and disease resistance van der Zijpp et al, 1988).…”

Section: Introductionmentioning

confidence: 94%

Production Traits and Alloantigen Systems in Lines of Chickens Selected for High or Low Antibody Responses to Sheep Erythrocytes

et al. 1990

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The selection of chickens for high (HA) and for low (LA) antibody titers to sheep erythrocytes has produced differences in the selected trait and in the correlated responses in body weight, egg production, and erythrocyte antigens. The response to selection continued through 14 generations. There was considerable divergence between lines for erythrocyte alloantigen systems, including the major histocompatibility complex. Females from Line LA were heavier as juveniles and lighter as adults, matured at a younger age, and had higher egg production than those from Line HA. There were no differences between lines for the incidence of defective eggs laid-except for the percentage of eggs with double-yolks, which was greater for Line LA than HA. The phenotypic correlations of antibody response with growth and with reproductive traits were very low; the genetic correlations were moderate to high for most of these traits.

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“…It declined after a few years and then fluctuated from year to year. Selection for antibody response in guinea pigs was also shown to have a high degree of fluctuation in mean antibody titer from generation to generation (Ibanez et al, 1980). Environmental changes seem to influence the response to selection for immune parameters.…”

Section: Discussionmentioning

confidence: 98%

“…This might not have been enough to establish stable high and low responder lines. Experiments in mice (Biozzi et al, 1979b), guinea pigs (Ibanez et al, 1980), and chickens (Pitcovski et al, 1988) showed that the divergence between the lines was in fact small after the first few generations. In these experiments the difference between the lines then increased in succeeding generations.…”

Section: Discussionmentioning

confidence: 99%

Selection for immune response in goats: the antibody response to diphtheria toxoid after 12 years of selection

Ådnøy²,

Klemetsdal³

et al. 1991

Journal of Animal Science

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A herd of Norwegian dairy goats was subject to selection for high and low antibody response to diphtheria toxoid for 12 yr, or approximately 5.5 generations because sires were used for one mating season, whereas dams were used several years. The herd comprised approximately 100 milking goats. Only sires were tested and selected, five to seven sires were used in each line each year, and the percentage of male kids used for breeding varied between 15 and 50%. The mean phenotypic values of the lines diverged until the 4th yr, but the lines did not diverge any further. The means of both lines decreased during the experimental period. The restricted maximum likelihood (REML) estimate of the heritability of the trait in the base population was .19, whereas the realized heritability approached zero in the last six cycles of selection. Using the REML-estimate of heritability in an individual animal model, the mean breeding values (BLUP) of the lines were significantly different. The difference in mean BLUP values between the lines increased throughout the study. Yet, this increase was only 40% from the 2nd to the 12th yr. No effect of a major gene was observed in a test based on individual BLUP.

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Selective breeding of high and Low antibody-responder lines of guinea pigs

Cited by 10 publications

References 4 publications

Allelic Frequencies in Eight Alloantigen Systems of Chickens Selected for High and Low Antibody Response to Sheep Red Blood Cells

Allelic Frequencies in Eight Alloantigen Systems of Chickens Selected for High and Low Antibody Response to Sheep Red Blood Cells

Production Traits and Alloantigen Systems in Lines of Chickens Selected for High or Low Antibody Responses to Sheep Erythrocytes

Selection for immune response in goats: the antibody response to diphtheria toxoid after 12 years of selection

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