Selective breeding for extremes in open-field activity of mice entails a differentiation of hippocampal mossy fibers

Hausheer-Zarmakupi, Zafiro; Wolfer, David P; Leisinger-Trigona, Marie-Claire; Lipp, Hans‐Peter

doi:10.1007/bf02359894

Cited by 36 publications

(18 citation statements)

References 38 publications

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“…Taken together, our results suggest that the modifications of MF synaptic transmission contribute to the regulation of the open‐field locomotor activity. It has been shown that the distribution of MFs is related to open‐field locomotor activity (Hausheer‐Zarmakupi et al ., 1996) and its habituation (Crusio & Schwegler, 1987). In addition to these morphological findings, our study provides physiological evidence supporting the idea that the MF system plays important roles in the regulation of the open‐field locomotor activity.…”

Section: Discussionmentioning

confidence: 99%

Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission

Kobayashi

Ikeda

Suzuki

2006

Eur J of Neuroscience

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The hippocampus has long been implicated in memory formation. Although accumulating evidence suggests involvement of the hippocampus in other brain functions including locomotor regulation and emotional processes, cellular and synaptic bases underlying these functions remain largely unknown. We here report that environmental manipulations in mice unveiled the association of locomotor activity with the hippocampal mossy fibre (MF) synaptic transmission. Electrophysiological recordings of synaptic responses were made using hippocampal slices prepared from mice whose behaviour had been analysed. Environmental enrichment induced parallel decreases in open-field locomotor activity and MF synaptic facilitation. Facilitation induced by paired-pulse stimulation at relatively long intervals (>or=200 ms) was selectively reduced while the basal synaptic efficacy and high-frequency transmission were unaffected. Social isolation caused a change in behaviour in an elevated plus-maze, but neither the open-field activity nor the MF synaptic transmission was significantly altered. Effects of dopamine, a neurotransmitter essential for locomotor regulation, on the MF synapse were also examined using these mice. Environmental manipulations did not cause significant changes in potentiation of the MF synaptic transmission induced by dopamine. However, analysis of behavioural and electrophysiological results in individual subjects revealed that locomotor activity negatively correlates with magnitude of the dopamine-induced potentiation. These results suggest that the MF synapse plays important roles in the regulation of locomotor activity. We propose that the MF synapse can serve as the synaptic model for certain forms of locomotor regulation, with potential importance for investigation of the pathophysiology of psychiatric diseases using animal models.

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Section: Discussionmentioning

confidence: 99%

Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission

Kobayashi

Ikeda

Suzuki

2006

Eur J of Neuroscience

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“…IIP-MF are reported to be smaller in aggressive strains of several models, namely, SAL vs LAL mice (Sluyter et al, 1994), C57BL/6JNmg vs C57BL/6J//Kun mice (Sluyter et al, 1999), as well as seven inbred strains (Guillot et al, 1994). In addition, IIP-MF were found to be both larger (Hausheer-Zarmakupi et al, 1996) and smaller (Crusio et al, 1989a,b) in mice showing high open-field exploration. Third, we wanted to test whether there was a link between IIP-MF and anxiety as studies in DA rats and BDE rats had suggested that larger IIP-MF might be related to lower anxiety (Prior et al, 1997) and as the level of anxiety represents the internal state related to risk-averse behaviors in an ecological context.…”

Section: Introductionmentioning

confidence: 89%

Exploration, emotionality, and hippocampal mossy fibers in nonaggressive AB/Gat and congenic highly aggressive mice

et al. 2003

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AB/Gat mice and congenic mice bred for high aggressiveness (CS/ag) were tested for exploratory behavior in novel situations and anxiety-related behavior, using an open-field test and the elevated plus-maze test. Subsequently, the size of hippocampal mossy fiber terminal fields was evaluated. Considerably higher exploratory activity was found in nonaggressive mice, whereas aggressive mice exhibited more anxiety-related behavior. Larger intra- and infrapyramidal mossy fiber terminal fields (IIP-MF) and a larger hilus were found in the highly aggressive strain. Within the nonaggressive AB/Gat strain, larger IIP-MF were correlated with higher exploratory behavior and lower anxiety in the plus-maze test. Within the aggressive strain, no individual correlations between hippocampal morphometry and behavior were found. The results corroborate the "ecotype hypothesis," which suggests that mice of subpopulations with highly aggressive males tend to display reduced exploratory behavior. The findings support the view that genetic factors involved in aggressive behavior also affect hippocampal connectivity. However, our results do not support the hypothesis that a higher level of aggressiveness is necessarily related to smaller IIP-MF.

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“…First, it has been reported that functional differences may be present along the transverse axis of the dentate granule cell population (Hara et al 1990;Jaarsma et al 1992;Scharfman et al 2002;Choi et al 2003;Witter 2007). Second, variations in the relative size/extent of the infrapyramidal pathway have been reported such that behavioral profiles apparently correlate to the extent of infrapyramidal mossy fiber innervation (Lipp et al 1987(Lipp et al , 1988Schopke et al 1991;Hausheer-Zarmakupi et al 1996).…”

Section: Dentate To Ca3 Projections-mossy Fibersmentioning

confidence: 99%

Intrinsic and extrinsic wiring of CA3: Indications for connectional heterogeneity

Witter¹

2007

Learning & Memory

206

195

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Selective breeding for extremes in open-field activity of mice entails a differentiation of hippocampal mossy fibers

Cited by 36 publications

References 38 publications

Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission

Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission

Exploration, emotionality, and hippocampal mossy fibers in nonaggressive AB/Gat and congenic highly aggressive mice

Intrinsic and extrinsic wiring of CA3: Indications for connectional heterogeneity

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