Selective breeding for deficient sensorimotor gating is accompanied by increased perseveration in rats

Freudenberg, Florian; Dieckmann, Marco; Winter, Sabrina; Koch, Mirja; Schwabe, Kerstin

doi:10.1016/j.neuroscience.2007.06.034

Cited by 26 publications

(23 citation statements)

References 49 publications

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“…The minor surgical procedure did not result in profound learning and memory deficits in a reversal learning version of the Morris water maze but aged surgical mice did tend to perseverate in the old target quadrant as well as spend less time swimming in the new target location. Perseveration indicates impaired ability to modulate behavior based upon new or changing information and may reflect a disruption in the integration of stored memory with current contextual information (Freudenberg et al, 2007). It has been previously shown that hippocampal-lesioned animals can acquire a place response in a water maze task but are impaired during reversal learning due to perseverative returns to the previous correct location (Whishaw and Tomie, 1997).…”

Section: Discussionmentioning

confidence: 99%

Neuroinflammation and cognitive function in aged mice following minor surgery

Rosczyk

Sparkman

Johnson

2008

Experimental Gerontology

244

192

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Following surgery, elderly patients often suffer from postoperative cognitive dysfunction (POCD) which can persist long after physical recovery. It is known that surgery-induced tissue damage activates the peripheral innate immune system resulting in the release of inflammatory mediators. Compared to adults, aged animals demonstrate increased neuroinflammation and microglial priming that leads to an exaggerated proinflammatory cytokine response following activation of the peripheral immune system. Therefore, we sought to determine if the immune response to surgical trauma results in increased neuroinflammation and cognitive impairment in aged mice. Adult and aged mice underwent minor abdominal surgery and 24 h later hippocampal cytokines were measured and working memory was assessed in a reversal learning version of the Morris water maze. While adult mice showed no signs of neuroinflammation following surgery, aged mice had significantly increased levels of IL-1β mRNA in the hippocampus. Minor surgery did not result in severe cognitive impairment although aged mice that underwent surgery did tend to perseverate in the old target during reversal testing suggesting reduced cognitive flexibility. Overall these results suggest that minor surgery leads to an exaggerated neuroinflammatory response in aged mice but does not result in significantly impaired performance in the Morris water maze.

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Section: Discussionmentioning

confidence: 99%

Neuroinflammation and cognitive function in aged mice following minor surgery

Rosczyk

Sparkman

Johnson

2008

Experimental Gerontology

244

192

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“…For instance, a number of animal models of PPI deficits have been developed, with the hope of understanding the etiology and pathophysiology of schizophrenia. Reduced PPI in rats is associated with increased perseverative responding during task switching (Freudenberg, Dieckmann, Winter, Koch, & Schwabe, 2007), which is often characteristic of schizophrenic patients during tasks such as the Wisconsin Card Sorting Test, which also requires behavioral flexibility and switching. Reduced levels of methylation of NRG1 have been reported in rats bred for reduced levels of PPI, and methylation levels are reduced in brain regions associated with both PPI and schizophrenia, such as medial PFC, hippocampus, nucleus accumbens (Rhein et al, 2013).…”

Section: 0 Where Do We Go From Here?mentioning

confidence: 99%

Endophenotype best practices

Iacono

Malone

Vrieze

2017

International Journal of Psychophysiology

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This review examines the current state of electrophysiological endophenotype research and recommends best practices that are based on knowledge gleaned from the last decade of molecular genetic research with complex traits. Endophenotype research is being oversold for its potential to help discover psychopathology relevant genes using the types of small samples feasible for electrophysiological research. This is largely because the genetic architecture of endophenotypes appears to be very much like that of behavioral traits and disorders: they are complex, influenced by many variants (e.g., tens of thousands) within many genes, each contributing a very small effect. Out of over 40 electrophysiological endophenotypes covered by our review, only resting heart, a measure that has received scant advocacy as an endophenotype, emerges as an electrophysiological variable with verified associations with molecular genetic variants. To move the field forward, investigations designed to discover novel variants associated with endophenotypes will need extremely large samples best obtained by forming consortia and sharing data obtained from genome wide arrays. In addition, endophenotype research can benefit from successful molecular genetic studies of psychopathology by examining the degree to which these verified psychopathology-relevant variants are also associated with an endophenotype, and by using knowledge about the functional significance of these variants to generate new endophenotypes. Even without molecular genetic associations, endophenotypes still have value in studying the development of disorders in unaffected individuals at high genetic risk, constructing animal models, and gaining insight into neural mechanisms that are relevant to clinical disorder.

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Section: Pathophysiology Of Tourette’s Syndromementioning

confidence: 99%

“…Normally, a prestimulus can prevent a startle response elicited by a stimulus, but this has been found to be deficient in TS (Castellanos et al 1996; Freudenberg et al 2007). This is thought to be due to deficient “gating” of sensorimotor information and has been modelled in rodents, pigs, and nonhuman primates (Swerdlow et al 2001; Swerdlow and Sutherland 2005; Freudenberg et al 2007; Hadamitzky et al 2007). In order to model the hyperactive basal ganglia and limbic circuitry thought to underlie TS, transgenic mice have been developed that have tonically hyperactive cortical and limbic circuits (Campbell et al 2000; McGrath et al 2000; Nordstrom and Burton 2002; Swerdlow and Sutherland 2005,2007).…”

Section: Pathophysiology Of Tourette’s Syndromementioning

confidence: 99%

Neurosurgical strategies for Gilles de la Tourette’s syndrome

Mukhida

Bishop²,

Hong³

et al. 2008

NDT

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Tourette’s syndrome (TS) is a neurological disorder characterized by motor and vocal tics that typically begin in childhood and often are accompanied by psychiatric comorbidities. Symptoms of TS may be socially disabling and cause secondary medical complications. Pharmacological therapies remain the mainstay of symptom management. For the subset of patients in whom TS symptoms are medically recalcitrant and do not dissipate by adulthood, neurosurgery may offer an alternative treatment strategy. Greater understanding of the neuroanatomic and pathophysiologic basis of TS has facilitated the development of surgical procedures that aim to ameliorate TS symptoms by lesions or deep brain stimulation of cerebral structures. Herein, the rationale for the surgical management of TS is discussed and neurosurgical experiences since the 1960s are reviewed. The necessity for neurosurgical strategies to be performed with appropriate ethical considerations is highlighted.

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Selective breeding for deficient sensorimotor gating is accompanied by increased perseveration in rats

Cited by 26 publications

References 49 publications

Neuroinflammation and cognitive function in aged mice following minor surgery

Neuroinflammation and cognitive function in aged mice following minor surgery

Endophenotype best practices

Neurosurgical strategies for Gilles de la Tourette’s syndrome

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Selective breeding for deficient sensorimotor gating is accompanied by increased perseveration in rats

Cited by 26 publications

References 49 publications

Neuroinflammation and cognitive function in aged mice following minor surgery

Neuroinflammation and cognitive function in aged mice following minor surgery

Endophenotype best practices

Neurosurgical strategies for Gilles de la Tourette&rsquo;s syndrome

Contact Info

Product

Resources

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Neurosurgical strategies for Gilles de la Tourette’s syndrome