Selective Autophagy in Hyperglycemia-Induced Microvascular and Macrovascular Diseases

Bharath, Leena P.; Rockhold, Jack Donato; Conway, Rachel

doi:10.3390/cells10082114

Cited by 20 publications

(19 citation statements)

References 110 publications

(113 reference statements)

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“…Autophagy plays a vital role in the development of various cardiovascular diseases (42). It has been reported that miR-34a suppresses autophagy in cancer cells (43).…”

Section: Mir-34a and Autophagy In The Cardiovascular Systemmentioning

confidence: 99%

Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

Hua

Liu

Liang³

et al. 2022

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality worldwide and include a group of disorders varying from vasculature, myocardium, arrhythmias and cardiac development. MicroRNAs (miRs) are endogenous non-coding RNAs with 18–23 nucleotides that regulate gene expression. The miR-34 family, including miR-34a/b/c, plays a vital role in the regulation of myocardial physiology and pathophysiological processes. Recently, miR-34a has been implicated in cardiovascular fibrosis, dysfunction and related cardiovascular disorders as an essential regulator. Interestingly, there is a pivotal link among miR-34a, cardiovascular fibrosis, and Smad4/TGF-β1 signaling. Notably, both loss-of-function and gain-of-function approaches identified the critical roles of miR-34a in cardiovascular apoptosis, autophagy, inflammation, senescence and remodeling by modulating multifunctional signaling pathways. In this article, we focus on the current understanding of miR-34a in biogenesis, its biological effects and its implications for cardiac pathologies including myocardial infarction, heart failure, ischaemia reperfusion injury, cardiomyopathy, atherosclerosis, hypertension and atrial fibrillation. Thus, further understanding of the effects of miR-34a on cardiovascular diseases will aid the development of effective interventions. Targeting for miR-34a has emerged as a potential therapeutic target for cardiovascular dysfunction and related diseases.

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“…Autophagy plays a vital role in the development of various cardiovascular diseases (42). It has been reported that miR-34a suppresses autophagy in cancer cells (43).…”

Section: Mir-34a and Autophagy In The Cardiovascular Systemmentioning

confidence: 99%

Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

Hua

Liu

Liang³

et al. 2022

Front. Cardiovasc. Med.

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“…In addition, Parkin dysfunction may lead to the loss of pancreatic β cells and the development of insulin deficiency [105]. Bharath and colleagues found that in diabetic mice, the level of p53 increased in β-cells, inhibiting Parkin-mediated mitophagy [106]. However, in p53 deficient mice, restored mitophagy protected β-cell loss induced by streptozotocin (STZ).…”

Section: Mitophagymentioning

confidence: 99%

The Role of Mitochondria in Metabolic Syndrome–Associated Cardiomyopathy

Chen

et al. 2022

Oxidative Medicine and Cellular Longevity

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With the rapid development of society, the incidence of metabolic syndrome (MS) is increasing rapidly. Evidence indicated that patients diagnosed with MS usually suffered from cardiomyopathy, called metabolic syndrome–associated cardiomyopathy (MSC). The clinical characteristics of MSC included cardiac hypertrophy and diastolic dysfunction, followed by heart failure. Despite many studies on this topic, the detailed mechanisms are not clear yet. As the center of cellular metabolism, mitochondria are crucial for maintaining heart function, while mitochondria dysfunction plays a vital role through mechanisms such as mitochondrial energy deprivation, calcium disorder, and ROS (reactive oxygen species) imbalance during the development of MSC. Accordingly, in this review, we will summarize the characteristics of MSC and especially focus on the mechanisms related to mitochondria. In addition, we will update new therapeutic strategies in this field.

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“…Autophagy is an important pathway for recycling through lysosomal removal of misfolded proteins, damaged organelles, etc ( Bravo-San Pedro et al, 2017 ). Mitochondrial autophagy is specific macroautophagy that selectively degrades damaged or senescent mitochondria for recycling and is susceptible to the intracellular environment ( Bharath et al, 2021 ; Chen et al, 2022b ). In AMPK knockout mouse embryonic fibroblasts, ULK1 is not activated, autophagy is inhibited and damaged mitochondria accumulate.…”

Section: Ampk Signalling Pathwaymentioning

confidence: 99%

Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway

et al. 2023

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Functional dyspepsia (FD) is the most common clinical gastrointestinal disease, with complex and prolonged clinical symptoms. The prevalence of FD is increasing year by year, seriously affecting the quality of life of patients. The main causes of FD are related to abnormal gastrointestinal dynamics, increased visceral sensitivity, Helicobacter pylori (HP) infection, intestinal flora disturbance and psychological factors. A review of the relevant literature reveals that the mechanisms of traditional Chinese medicine (TCM) in the treatment of FD mainly involve the following pathways:5-HT signal pathway, AMPK signal pathway,C-kit signal pathway, CRF signal pathway, PERK signal pathway,NF-κB signal pathway. Based on a holistic concept, TCM promotes gastrointestinal motility, regulates visceral sensitivity and alleviates gastrointestinal inflammation through multiple signal pathways, reflecting the advantages of multi-level, multi-pathway and multi-targeted treatment of FD.

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Selective Autophagy in Hyperglycemia-Induced Microvascular and Macrovascular Diseases

Cited by 20 publications

References 110 publications

Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

The Role of Mitochondria in Metabolic Syndrome–Associated Cardiomyopathy

Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway

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