Selective attentional impairment in chronic tinnitus: Evidence from an event-related potentials study

Mannarelli, Daniela; Pauletti, Caterina; Mancini, Patrizia; Fioretti, Alessandra; Greco, Antonio; Vincentiis, Marco de; Fattapposta, Francesco

doi:10.1016/j.clinph.2016.12.028

Cited by 23 publications

(27 citation statements)

References 49 publications

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“…This finding is novel given the nature of applied methodologies and the withingroup analysis in contrast to between-group findings of lower intelligence 27,35,37 , various impaired cognitive www.nature.com/scientificreports/ abilities except long-term memory 54 , increased risk of Alzheimer's and Parkinson's disease 55 , and lower TMT performance 27,[34][35][36] in tinnitus patients. In some studies these behavioral findings were further corroborated by neurophysiology, mostly in the form of longer latencies of standard event-related EEG components in auditory oddball tasks 54,56 . Yet, while not directly applicable, results from theses studies fit our hypothesis with respect to intelligence as measured by the MWT-B while we could not find any effect for the TMT-A.…”

Section: Discussionmentioning

confidence: 74%

“…Cognitive tests are furthermore naturally linked to neuropsychology, which implies the use of respective neuroscientific methods. Some previous studies combined behavioral and neurophysiological methods for the study of cognition, mostly attention, in tinnitus (e.g., 35 , 54 , 56 , 64 – 66 ). Various task-related or group-specific maladaptive alterations of neurophysiology were reported for tinnitus patients in these studies.…”

Section: Discussionmentioning

confidence: 99%

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The impact of tinnitus distress on cognition

Neff

Simões

Psatha

et al. 2021

Sci Rep

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Tinnitus is the chronic perception of a phantom sound with different levels of related distress. Past research has elucidated interactions of tinnitus distress with audiological, affective and further clinical variables. The influence of tinnitus distress on cognition is underinvestigated. Our study aims at investigating specific influences of tinnitus distress and further associated predictors on cognition in a cohort of n = 146 out-ward clinical tinnitus patients. Age, educational level, hearing loss, Tinnitus Questionnaire (TQ) score, tinnitus duration, speech in noise (SIN), stress, anxiety and depression, and psychological well-being were included as predictors of a machine learning regression approach (elastic net) in three models with scores of a multiple choice vocabulary test (MWT-B), or two trail-making tests (TMT-A and TMT-B), as dependent variables. TQ scores predicted lower MWT-B scores and higher TMT-B test completion time. Stress, emotional, and psychological variables were not found to be relevant predictors in all models with the exception of small positive influences of SIN and depression on TMT-B. Effect sizes were small to medium for all models and predictors. Results are indicative of specific influence of tinnitus distress on cognitive performance, especially on general or crystallized intelligence and executive functions. More research is needed at the delicate intersection of tinnitus distress and cognitive skills needed in daily functioning.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

The impact of tinnitus distress on cognition

Neff

Simões

Psatha

et al. 2021

Sci Rep

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“…Regarding the P300 component, one study reported significant positive correlations between its latency and scores on the Hamilton Rating Scale for Depression (HAM-D) and Anxiety (HAM-A), as well as scores on the Mini-Mental State Exam (MMSE) [48]. A different group of authors did not find any significant correlations between P300 amplitude or latency and scores on the THI [53]. No consistent correlations between any of the other LAEP components and subjective tinnitus severity were found.…”

Section: Correlations Between Laep Components and Subjective Measuresmentioning

confidence: 98%

Systematic review and meta-analysis of late auditory evoked potentials as a candidate biomarker in the assessment of tinnitus

et al. 2020

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Subjective tinnitus, the perception of sound in the absence of any sound source, is routinely assessed using questionnaires. The subjective nature of these tools hampers objective evaluation of tinnitus presence, severity and treatment effects. Late auditory evoked potentials (LAEPs) might be considered as a potential biomarker for assessing tinnitus complaints. Using a multivariate meta-analytic model including data from twenty-one studies, we determined the LAEP components differing systematically between tinnitus patients and controls. Results from this model indicate that amplitude of the P300 component is lower in tinnitus patients (standardized mean difference (SMD) = -0.83, p < 0.01), while latency of this component is abnormally prolonged in this population (SMD = 0.97, p < 0.01). No other investigated LAEP components were found to differ between tinnitus and non-tinnitus subjects. Additional sensitivity analyses regarding differences in experimental conditions confirmed the robustness of these results. Differences in age and hearing levels between the two experimental groups might have a considerable impact on LAEP outcomes and should be carefully considered in future studies. Although we established consistent differences in the P300 component between tinnitus patients and controls, we could not identify any evidence that this component might covary with tinnitus severity. We conclude that out of several commonly assessed LAEP components, only the P300 can be considered as a potential biomarker for subjective tinnitus, although more research is needed to determine its relationship with subjective tinnitus measures. Future trials investigating experimental tinnitus therapies should consider including P300 measurements in the evaluation of treatment effect.

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“…Alterations of the default mode network and cognitive impairment in patients with unilateral chronic tinnitus deficits are prevalent among tinnitus patients. The cognitive dysfunction may be linked with neuropathological changes in chronic tinnitus (11)(12)(13)(14). However, the exact neural mechanism of the cognitive impairment which is related to chronic tinnitus remains to be determined.…”

Section: Original Articlementioning

confidence: 99%

Alterations of the default mode network and cognitive impairment in patients with unilateral chronic tinnitus

Chen¹,

Zhang²,

Kong³

et al. 2018

Quant. Imaging Med. Surg

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Background: Previous studies have demonstrated that cognitive impairment is linked with neurophysiological alterations in chronic tinnitus. This study aimed to investigate the intrinsic functional connectivity (FC) pattern within the default mode network (DMN) and its associations with cognitive impairment in tinnitus patients using a resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Thirty-five chronic unilateral tinnitus patients, and 50 healthy controls were recruited for rsfMRI scanning. Both groups were age, gender and education level well-matched. The posterior cingulate cortex (PCC) was chosen as the region of interest (ROI) for detecting the FC changes, and determining if these abnormalities were related to a specific cognitive performance and tinnitus characteristic. Results: Relative to the healthy controls, tinnitus patients showed increased FC between the PCC and the right medial prefrontal cortex (mPFC). Moreover, the enhanced FC between the PCC and right mPFC was correlated with the poorer TMT-B scores (r=0.474, P=0.008). These correlations were adjusted by age, gender, education level, GM volume, and mean hearing thresholds. The enhanced FC was not correlated with other tinnitus characteristics or cognitive performances. Conclusions: The enhanced FC pattern of the PCC that is correlated with cognitive impairment in chronic tinnitus patients, especially the executive dysfunction. Enhanced connectivity pattern within the DMN may play a crucial role in neurophysiological mechanism in tinnitus patients with cognitive dysfunction.

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Selective attentional impairment in chronic tinnitus: Evidence from an event-related potentials study

Cited by 23 publications

References 49 publications

The impact of tinnitus distress on cognition

The impact of tinnitus distress on cognition

Systematic review and meta-analysis of late auditory evoked potentials as a candidate biomarker in the assessment of tinnitus

Alterations of the default mode network and cognitive impairment in patients with unilateral chronic tinnitus

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