Selective Assay Procedure for Chlorpropamide in the Presence of its Decomposition Products

Thermal Dissociation of Sulfonylureas II: Dissociation of Four N- and N′-Substituted Sulfonylureas in Different Media

“…Compound 111 and piperidine salt of 111-the analysis was carried out as described for I. 4. Compound IV-evaporation of the extract yielded quantitatively the starting material.…”

“…Although a hydrolytic process is most frequently observed in such decompositions (1)(2)(3)(4), cases of thermal dissociation were reported (5, 6). Although a hydrolytic process is most frequently observed in such decompositions (1)(2)(3)(4), cases of thermal dissociation were reported (5, 6).…”

“…Keyphrases 0 Sulfonylureas-thermal dissociation in alcohols, water, and amines, mechanism 0 Tolbutamide and related sulfonylureas-thermal dissociation in alcohols, water, and amines, mechanism Dissociation, thermal, tolbutamide and related sulfonylureas-in alcohols, water, and amines, mechanism Sulfonylureas, a class to which belong some important oral hypoglycemic agents, are known to undergo a breakdown under various experimental conditions. Although a hydrolytic process is most frequently observed in such decompositions (1)(2)(3)(4), cases of thermal dissociation were reported (5, 6). Symmetrically substituted sulfonylureas such as tolbutamide (I) can theoretically yield on dissociation either an alkyl (path a) or an arylsulfonyl isocyanate (path b), as indicated in Scheme I.…”