“…Keyphrases 0 Sulfonylureas-thermal dissociation in alcohols, water, and amines, mechanism 0 Tolbutamide and related sulfonylureas-thermal dissociation in alcohols, water, and amines, mechanism Dissociation, thermal, tolbutamide and related sulfonylureas-in alcohols, water, and amines, mechanism Sulfonylureas, a class to which belong some important oral hypoglycemic agents, are known to undergo a breakdown under various experimental conditions. Although a hydrolytic process is most frequently observed in such decompositions (1)(2)(3)(4), cases of thermal dissociation were reported (5, 6). Symmetrically substituted sulfonylureas such as tolbutamide (I) can theoretically yield on dissociation either an alkyl (path a) or an arylsulfonyl isocyanate (path b), as indicated in Scheme I.…”