Selective anterior cingulate cortex deficit during conflict solution in schizophrenia: An event-related potential study

Neuhaus, Andres H.; Koehler, Simone; Opgen‐Rhein, Carolin; Urbanek, Carsten; Hahn, Eric; Dettling, Michael

doi:10.1016/j.jpsychires.2006.06.012

Cited by 74 publications

(57 citation statements)

References 51 publications

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“…A trend for deficits on the executive control subtest of the Attention Network Test (but not on alerting or orienting subtests) was observed in the CUDÀ subgroup (as compared with controls), a novel finding in the drug addiction literature; such specificity was previously reported only in patients with schizophrenia Neuhaus et al, 2007). Performance on this particular subtest of the Attention Network Test is associated with the anterior cingulate cortex, and with left lateral prefrontal, primary, and supplementary motor areas as measured with functional magnetic resonance imaging and source analysis of an event related potential component (P300) latency (Fan et al, 2003(Fan et al, , 2007.…”

Section: Impairment Of Attention and Executive Function In Cocaine Abmentioning

confidence: 62%

The Neuropsychology of Cocaine Addiction: Recent Cocaine Use Masks Impairment

Woicik

Moeller

Alia‐Klein

et al. 2008

Neuropsychopharmacol

174

134

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Individuals with current cocaine use disorders (CUD) form a heterogeneous group, making sensitive neuropsychological (NP) comparisons with healthy individuals difficult. The current study examined the effects on NP functioning of four factors that commonly vary among CUD: urine status for cocaine (positive vs negative on study day), cigarette smoking, alcohol consumption, and dysphoria. Sixty-four cocaine abusers were matched to healthy comparison subjects on gender and race; the groups also did not differ in measures of general intellectual functioning. All subjects were administered an extensive NP battery measuring attention, executive function, memory, facial and emotion recognition, and motor function. Compared with healthy control subjects, CUD exhibited performance deficits on tasks of attention, executive function, and verbal memory (within one standard deviation of controls). Although CUD with positive urine status, who had higher frequency and more recent cocaine use, reported greater symptoms of dysphoria, these cognitive deficits were most pronounced in the CUD with negative urine status. Cigarette smoking, frequency of alcohol consumption, and dysphoria did not alter these results. The current findings replicate a previously reported statistically significant, but relatively mild NP impairment in CUD as compared with matched healthy control individuals and further suggest that frequent/recent cocaine may mask underlying cognitive (but not mood) disturbances. These results call for development of pharmacological agents targeted to enhance cognition, without negatively impacting mood in individuals addicted to cocaine.

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Section: Impairment Of Attention and Executive Function In Cocaine Abmentioning

confidence: 62%

The Neuropsychology of Cocaine Addiction: Recent Cocaine Use Masks Impairment

Woicik

Moeller

Alia‐Klein

et al. 2008

Neuropsychopharmacol

174

134

View full text Add to dashboard Cite

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“…It was expected that participants with schizophrenia would show more impaired accuracy across and within nicotine conditions (Gooding et al, 2005;Wang et al, 2005), though similar rates to controls are known in those with paranoid schizophrenia (Neuhaus et al, 2006). In fact, accurate information processing was most impaired following nicotine withdrawal.…”

Section: Discussionmentioning

confidence: 99%

Early nicotine withdrawal and transdermal nicotine effects on neurocognitive performance in schizophrenia

AhnAllen

Nestor

Shenton

et al. 2008

Schizophrenia Research

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As cigarette smoking prevalence rates approach 90% in schizophrenia, an important emerging question is the role of nicotine in the disease-related disturbance in cognition. We therefore tested a total of 38 male cigarette smokers (22 schizophrenia, 16 normal control), matched on nicotine dependence, on the Attention Network Test (ANT) at three nicotine conditions (baseline, 8hr overnight withdrawal, 3hr 21mg nicotine patch). The results indicated that the groups did not differ in performance on either of three ANT measures (alertness, orienting, and executive) across baseline, patch, and withdrawal conditions. However, in comparison to the controls, the participants with schizophrenia showed faster ANT reaction time (RT) for the nicotine patch in relation to the baseline condition. In comparison to controls, the participants with schizophrenia also showed reduced ANT accuracy at withdrawal but not at patch condition. These results suggest that overall processing speed and accuracy are affected differently by nicotine levels in participants with schizophrenia, with evidence supporting greater impairment from withdrawal and greater improvement from nicotine administration.

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“…To this end, the present study assessed how four doses of our Treatment variable (0 mg, 100 mg, 200 mg, 400 mg caffeine) would affect habitual consumers' performance on the Attention Network Test (ANT; Fan, McCandliss, Sommer, Raz, & Posner, 2002). The ANT is a composite task that reliably tests the independent functioning of three theorized (Posner, 1990) visual attention networks: alerting, orienting, and executive control (Fan et al, 2002(Fan et al, , 2003Neuhaus et al, 2007;Posner & Rothbart, 2005).…”

Section: The Present Studymentioning

confidence: 99%

Acute caffeine consumption enhances the executive control of visual attention in habitual consumers

Brunyé

Mahoney

Lieberman

et al. 2010

Brain and Cognition

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a b s t r a c tRecent work suggests that a dose of 200-400 mg caffeine can enhance both vigilance and the executive control of visual attention in individuals with low caffeine consumption profiles. The present study seeks to determine whether individuals with relatively high caffeine consumption profiles would show similar advantages. To this end, we examined the effects of four caffeine doses (0 mg, 100 mg, 200 mg, 400 mg) on low-and high-level visual attention in individuals with high consumption profiles (n = 36), in a double-blind study using a repeated measures design. Results from the Attention Network Test indicated that caffeine enhanced both vigilance and the executive control of visual attention, but only at the highest administered dose (400 mg). We demonstrate that in habitual consumers high doses of caffeine can produce beneficial changes in visual attention. These results carry implications for the theorized interactions between caffeine, adenosine and dopamine in brain regions mediating visual attention.Published by Elsevier Inc.

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Selective anterior cingulate cortex deficit during conflict solution in schizophrenia: An event-related potential study

Cited by 74 publications

References 51 publications

The Neuropsychology of Cocaine Addiction: Recent Cocaine Use Masks Impairment

The Neuropsychology of Cocaine Addiction: Recent Cocaine Use Masks Impairment

Early nicotine withdrawal and transdermal nicotine effects on neurocognitive performance in schizophrenia

Acute caffeine consumption enhances the executive control of visual attention in habitual consumers

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