The translation of
small molecule chemistries into efficient methodologies for polymer
functionalization spans several decades, enabling critical advances
in soft matter materials synthesis with tailored and adaptive property
profiles. The present Perspective exploresbased on selected
examples50 years of innovation in polymer functionalization
chemistries. These span a diverse set of chemistries based on activated
esters, thiol–ene/yne processes, nucleophilic systems based
on isocyanates, reactions driven by the formation of imines and oximes,
ring-opening processes, cycloadditions, andin a recent renaissancemulticomponent
reactions. In addition, a wide variety of chain types and architectures
have been modified based on the above chemistries, often with exquisite
chemical control, highlighted by key examples. We conclude our journey
through polymer functionalization with thein our viewmost
critically required advances that have the potential to move from
“science fiction” to “science fact”.