Selective and sensitive determination of amisulpride in human plasma by liquid chromatography–tandem mass spectrometry with positive electrospray ionisation and multiple reaction monitoring

Gschwend, Michael H.; Arnold, Peter; Ring, J.; Martin, William

doi:10.1016/j.jchromb.2005.11.042

Cited by 32 publications

(23 citation statements)

References 10 publications

(49 reference statements)

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“…Detection was carried out on an Agilent 6410B triple-quadrupole mass spectrometer with positive ESI. The quantification was performed using multiple reaction monitoring (MRM) and the nebulizer gas was nitrogen [32]. The gas follow was 10 mL/min with temperature of 350 °C, nebulizer pressure was set as 30 psi and capillary voltage was 4000V.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Tertiary amine mediated targeted therapy against metastatic lung cancer

Zhou

et al. 2016

Journal of Controlled Release

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Section: Accepted Manuscriptmentioning

confidence: 99%

Tertiary amine mediated targeted therapy against metastatic lung cancer

Zhou

et al. 2016

Journal of Controlled Release

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“…Various conclusions have been drawn from these studies, but the extent to which this drug degrades remains uncertain and there is little information published on any other AP. Stability studies have targeted either a single or a few drugs and are mainly carried out using a plasma matrix [20][21][22][23]. In contrast, there is little information available on the Figure 5.…”

Section: Study Of Long-term Stability Of Qti Spiked Whole Blood Samplesmentioning

confidence: 99%

Selective RP-HPLC method for determination of quetiapine in presence of coadministered drugs: Application for long-term stability study of quetiapine in whole blood

Youssef

Abdine

Barary

et al. 2016

Acta Chromatographica

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Summary. Incidence of suicidal attempts presents an explanation for the high prevalence of quetiapine (QTI) in forensic cases. Thus, the interpretation of its concentrations in biological specimens is needed, but in forensic toxicology, potential postmortem changes such as instability of the target drugs should be taken in consideration. Highperformance liquid chromatography (HPLC) method has been developed for determination of QTI. This method was based on reversed phase (RP)-HPLC separation of QTI on a C-18 column (150 mm × 4.6 mm, 5 μm) with elution system of acetonitrile-methanol-0.025 M phosphate buffer (pH 2.5), containing 1 mL TEA in each 250 mL, in a ratio of 40:30:30%, v/v, at the flow rate of 1.2 mL min −1 using mirtazapine as internal standard (IS). The proposed method was applied to the determination of QTI in plasma in presence of coadministered drugs. The application of the proposed method was extended for long-term stability study of two different concentration levels of QTI in the whole blood.

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“…Most of them have been applied for the simultaneous determination of several drugs for, e.g., screening, toxicological and forensic purposes (Frahnert et al, 2003;Kirchherr and Kuehn-Velten, 2006;Kratzsch et al, 2003). The analysis of amisulpride alone (or together with other benzamides) in biological fluids has been carried out using liquid chromatographic methods (Bohbot et al, 1987;Gschwend et al, 2006;Malavasi et al, 1996;Pehourcq et al, 2003;Sachse et al, 2003). Recently Gschwend et al (2006) reported a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the determination of amisulpride in human plasma in the concentration range 0.5 -500.52 ng/mL.…”

Section: Mass Spectrometrymentioning

confidence: 99%

“…The analysis of amisulpride alone (or together with other benzamides) in biological fluids has been carried out using liquid chromatographic methods (Bohbot et al, 1987;Gschwend et al, 2006;Malavasi et al, 1996;Pehourcq et al, 2003;Sachse et al, 2003). Recently Gschwend et al (2006) reported a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the determination of amisulpride in human plasma in the concentration range 0.5 -500.52 ng/mL. The lower limit of The dwell time for each reaction was kept to 200 ms. Collision energy and collision cell exit potential were set at 35 (arbitrary units) and at 18 (arbitrary units) respectively.…”

Section: Mass Spectrometrymentioning

confidence: 99%

Liquid chromatography tandem mass spectrometry method for the quantification of amisulpride with LLOQ of 100 pg/mL using 100 µL of plasma

Nirogi

Bhyrapuneni

Kandikere

et al. 2008

Biomedical Chromatography

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A sensitive and selective high-performance liquid chromatography-positive ion electrospray tandem mass spectrometry method was developed and validated for the quantification of amisulpride in 100 microL of human plasma. Following liquid-liquid extraction, the analytes were separated using an isocratic mobile phase on a reverse-phase column and analyzed by MS/MS in the multiple reaction monitoring mode using the respective (M + H)(+) ions, m/z 370-242 for amisulpride and m/z 341-112 for the internal standard. The assay exhibited a linear dynamic range with a lower range of 0.1-100 ng/mL and a higher range of 1-500 ng/mL of amisulpride in human plasma. The lower limit of quantification was 0.1 ng/mL with a relative standard deviation of less than 10%. Acceptable precision and accuracy were obtained for both linearity ranges. A run time of 2.0 min for each sample made it possible to analyze more than 275 human plasma samples per day. The validated method has been successfully used to analyze plasma samples for application in pharmacokinetic studies.

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Selective and sensitive determination of amisulpride in human plasma by liquid chromatography–tandem mass spectrometry with positive electrospray ionisation and multiple reaction monitoring

Cited by 32 publications

References 10 publications

Tertiary amine mediated targeted therapy against metastatic lung cancer

Tertiary amine mediated targeted therapy against metastatic lung cancer

Selective RP-HPLC method for determination of quetiapine in presence of coadministered drugs: Application for long-term stability study of quetiapine in whole blood

Liquid chromatography tandem mass spectrometry method for the quantification of amisulpride with LLOQ of 100 pg/mL using 100 µL of plasma

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