Selective and sensitive detection of cholesterol using intrinsic peroxidase-like activity of biogenic palladium nanoparticles

Rastogi, Lori; Dash, K.; Sashidhar, R.B.

doi:10.1016/j.crbiot.2021.02.001

Cited by 18 publications

(13 citation statements)

References 42 publications

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“…The results could be clearly observed by the naked eye, confirming the detection of cholesterol with a quantification limit of 3.7 μM. 103 Compared with immunological sensing methods, NMNPbased colorimetric assays are promising because of their low cost and simplicity of operation without the requirement to washing steps. However, they can only be employed in single-target assays.…”

Section: Diagnostic Applications Of Nmnps At Thementioning

confidence: 55%

“…As shown in Figure 5c, the intensity of the color developed on the folic acid−GO−PtNPs solution is proportional to the concentration of cancer cells in the sample analyte with a detection limit of 125 MCF-7 cells. 99 Using a similar method, Rastogi et al 103 used the catalytic activity of PdNPs for the specific and sensitive detection of cholesterol in human blood serum (Figure 5d). 103 They utilized gum kondagogu as both reducing and stabilizing agents of PdNPs.…”

Section: Diagnostic Applications Of Nmnps At Thementioning

confidence: 99%

“…99 Using a similar method, Rastogi et al 103 used the catalytic activity of PdNPs for the specific and sensitive detection of cholesterol in human blood serum (Figure 5d). 103 They utilized gum kondagogu as both reducing and stabilizing agents of PdNPs. In the presence of oxygen, cholesterol oxidase catalyzes the oxidation of cholesterol to produce 4-cholesten-3-1 and hydrogen peroxide (H 2 O 2 ).…”

Section: Diagnostic Applications Of Nmnps At Thementioning

confidence: 99%

“…(a–d) Absorption values and developed color intensities are proportional to the concentration of target molecules in the analyte samples. Reproduced with permission from ref . Copyright 2021 Elsevier.…”

Section: Diagnostic Applications Of Nmnps At the Point-of-needmentioning

confidence: 99%

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Noble-Metal Nanoparticle-Based Colorimetric Diagnostic Assays for Point-of-Need Applications

Nilghaz

Mousavi

Tian

et al. 2021

ACS Appl. Nano Mater.

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Noble-metal nanoparticles (NMNPs) have unique properties beneficial for the development of novel reporting technologies to enhance the detection sensitivity and specificity of clinically validated biomarkers. Unique size-and shape-dependent optical, catalytic, and magnetic properties of NMNPs have enabled significant advances in biosensing due to facilitation of colorimetric detection, localized surface plasmon resonance, fluorescence enhancement/quenching, surface-enhanced Raman scattering, electrochemical activity, etc. Among these, the colorimetric detection method is highly attractive for use in point-of-need diagnostic applications in which color changes in the presence of biomarkers can be directly observed with the naked eye without the requirement of any equipment. This capability fulfills one of the main requirements set by the World Health Organization to provide people living in remote/regional/low-resource settings access to effective and comprehensive primary care. Although there are many scientific publications, the commercialization of NMNP-based colorimetric diagnostic assays for point-of-need applications is lagging mainly because of the lack of knowledge related to NMNPs in dealing with biological samples and sensitivity of the tests required for the real-world applications. Herein, we provide a critical review of the fundamentals of NMNPs and the recent progress in their usage for monitoring and detecting clinically relevant biomarkers in biological samples at the point-of-need to scientifically assess the benefits and limitations of this technology. We then compare the methods employed to enhance the sensitivity of colorimetric assays in detecting clinically validated target biomarkers in body fluids. Finally, we investigate the future trends and strategies that deserve more research to increase the successful commercialization of these assays.

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Section: Diagnostic Applications Of Nmnps At Thementioning

confidence: 55%

Section: Diagnostic Applications Of Nmnps At Thementioning

confidence: 99%

Section: Diagnostic Applications Of Nmnps At Thementioning

confidence: 99%

Section: Diagnostic Applications Of Nmnps At the Point-of-needmentioning

confidence: 99%

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Noble-Metal Nanoparticle-Based Colorimetric Diagnostic Assays for Point-of-Need Applications

Nilghaz

Mousavi

Tian

et al. 2021

ACS Appl. Nano Mater.

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“…From the absorbance properties of PdNPs arises the necessity of designing synthetic routes to fabricate Pd nanoparticles with well-defined optical features, so that, despite the potential to become the third plasmonic sensing material, its use in colorimetric detection based on LSPR shifts remains unexplored, and in this work, we will consider the use of PdNPs in colorimetric assays only on the basis of their enzyme-mimic activity. In the work of Rastogi [62], Pd nanoparticles have been synthesized in a simple single-step green method, using the gum kondagogu (GK) as the reducing and capping agent. In the presence of TMB and H 2 O 2 , the so-obtained Pd nanoparticles (GK-Pd NPs) displayed a good peroxidase-like activity, thus showing the potential for the colorimetric detection of cholesterol.…”

Section: Colorimetric Detection Based On Catalysis By Enzyme-mimic Na...mentioning

confidence: 99%

Hybrid Nanocomposites of Plasmonic Metal Nanostructures and 2D Nanomaterials for Improved Colorimetric Detection

et al. 2022

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Plasmonic phenomena and materials have been extensively investigated for a long time and gained popularity in the last few years, finding in the design of the biosensors platforms promising applications offering devices with excellent performances. Hybrid systems composed of graphene, or other 2D materials, and plasmonic metal nanostructures present extraordinary optical properties originated from the synergic connection between plasmonic optical effects and the unusual physicochemical properties of 2D materials, thus improving their application in a broad range of fields. In this work, firstly, an overview of the structures and properties of 2D nanomaterials will be provided along with the physics of surface plasmon resonance and localized surface plasmon resonance. In the second part of the work, some examples of colorimetric biosensors exploiting the outstanding properties of hybrids nanocomposites will be presented. Finally, concluding perspectives on the actual status, challenges, and future directions in plasmonic sensing biosensing will be provided. Special emphasis will be given to how this technology can be used to support digitalization and virtualization in pandemic handling.

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N, S-co-doped carbon/Co1-xS nanocomposite with dual-enzyme activities for a smartphone-based colorimetric assay of total cholesterol in human serum

Liu

Dahlgren

et al. 2022

Analytica Chimica Acta

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Selective and sensitive detection of cholesterol using intrinsic peroxidase-like activity of biogenic palladium nanoparticles

Cited by 18 publications

References 42 publications

Noble-Metal Nanoparticle-Based Colorimetric Diagnostic Assays for Point-of-Need Applications

Noble-Metal Nanoparticle-Based Colorimetric Diagnostic Assays for Point-of-Need Applications

Hybrid Nanocomposites of Plasmonic Metal Nanostructures and 2D Nanomaterials for Improved Colorimetric Detection

N, S-co-doped carbon/Co1-xS nanocomposite with dual-enzyme activities for a smartphone-based colorimetric assay of total cholesterol in human serum

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