Selective and rapid water transportation across a self-assembled peptide-diol channel <i>via</i> the formation of a dual water array

Mondal, Debashis; Dandekar, Bhupendra R.; Ahmad, Manzoor; Mondal, Abhishek; Mondal, Jagannath; Talukdar, Pinaki

doi:10.1039/d2sc01737g

Cited by 11 publications

(12 citation statements)

References 64 publications

(101 reference statements)

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“…2E), confirming the anion (X − /OH − ) antiport as the mechanism of ion transport by the pyrrole amides. To probe for the possible detergent effect by the transporters on the lipid membrane, CF leakage assay 50 was performed by treating EYPC-LUVs⊃CF (Fig. S17†) with transporter 2c .…”

Section: Resultsmentioning

confidence: 99%

Bimodal structural tuning of pyrrole-2-carboxamide-based transmembrane ion transport systems

2023

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Section: Resultsmentioning

confidence: 99%

Bimodal structural tuning of pyrrole-2-carboxamide-based transmembrane ion transport systems

2023

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“…These values are practically within the same order of magnitude of ∼10 7 water molecules/ s/channel as those observed for other pillarene channels reported by Hou et al 12,31 or by us 13 or hydroxy channels. 32,33 More importantly, salt rejection and the extremely low proton permeability through hydrophobically sterically restricted channels offer the closest functional mimic of the natural aquaporin through a synthetic scaffold. These channels can be easily synthesized via simple self-assembly processes from simple components and are the first ones of this class of metallosupramolecular channels showing selective water permeation.…”

Section: ■ Conclusionmentioning

confidence: 99%

Self-Assembling Peptide-Appended Metallomacrocycle Pores for Selective Water Translocation

Huang,

Mamiya,

Baaden

et al. 2023

ACS Appl. Mater. Interfaces

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Artificial water channels selectively transport water, excluding all ions. Unimolecular channels have been synthesized via complex synthetic steps. Ideally, simpler compounds requesting less synthetic steps should efficiently lead to selective channels by self-assembly. Herein, we report a self-assembled peptide-bound Ni 2+ metallomacrocycle, 1, in which rim-peptide-bound units are connected to a central macrocycle obtained via condensation in the presence of Ni 2+ ions. Compound 1 achieves a single-channel permeability up to 10 7 −10 8 water/s/channel and insignificant ion transport, which is 1 order of magnitude lower than those for aquaporins. Molecular simulations probe that spongelike aggregates can form to generate transient cluster water pathways through the bilayer. Altogether, adaptive metallosupramolecular self-assembly is an efficient and simple way to construct selective channel superstructures.

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“…The peptide-diol dimers aggregate in a stacked cylindrical channel that forms an adequate cavity for water recognition and salt exclusion ( Figure 24 ). The water and ion transport of these structures were evaluated into lipid bilayer membranes, and the obtained results showed high water permeability and no cation, anion, or proton transport ( Figure 25 ) [ 69 ].…”

Section: Artificial Proton Channelsmentioning

confidence: 99%

“…( b ) Schematic representation of the stacking dimer units self-assembled into water selective channel. Adapted with permission from Reference [ 69 ] Copyright © 2022, Royal Society Chemistry publishing.…”

Section: Figurementioning

confidence: 99%

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Biomimetic Artificial Proton Channels

Andrei

Barboiu

2022

Biomolecules

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One of the most common biochemical processes is the proton transfer through the cell membranes, having significant physiological functions in living organisms. The proton translocation mechanism has been extensively studied; however, mechanistic details of this transport are still needed. During the last decades, the field of artificial proton channels has been in continuous growth, and understanding the phenomena of how confined water and channel components mediate proton dynamics is very important. Thus, proton transfer continues to be an active area of experimental and theoretical investigations, and acquiring insights into the proton transfer mechanism is important as this enlightenment will provide direct applications in several fields. In this review, we present an overview of the development of various artificial proton channels, focusing mostly on their design, self-assembly behavior, proton transport activity performed on bilayer membranes, and comparison with protein proton channels. In the end, we discuss their potential applications as well as future development and perspectives.

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Selective and rapid water transportation across a self-assembled peptide-diol channel via the formation of a dual water array

Abstract: Achieving superfast water transport by synthetically designed molecular artifacts, which exclude salts and protons, is a challenging task in separation science today, as it requires the concomitant presence of a...

Cited by 11 publications

References 64 publications

Bimodal structural tuning of pyrrole-2-carboxamide-based transmembrane ion transport systems

Bimodal structural tuning of pyrrole-2-carboxamide-based transmembrane ion transport systems

Self-Assembling Peptide-Appended Metallomacrocycle Pores for Selective Water Translocation

Biomimetic Artificial Proton Channels

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