Selective and Non-Selective β-Adrenoreceptor Blockade in the Human Forearm

Hartling, O. J.; Noer, Ivan; Tl, Svendsen; Clausen, Jan; Trap‐Jensen, J.

doi:10.1042/cs0580279

Cited by 42 publications

(28 citation statements)

References 13 publications

(14 reference statements)

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“…They suggested that this might be due to the non-,/-blocking actions of alprenolol. However, Kaiser and Tesch reported another study with crossover placebo control that indicated no difference of intramuscular lactate concentration between propranolol (80 mg) and control treatment.27 In our study, atenolol clearly did not affect the lactate response, and we believe this rules out involvement of the 61, receptor, although this does not agree with findings made during forearm exercise by Hartling et al 28 The results are most consistent with a /82-mediated antagonism by propranolol of lactate production by glycolysis or glycogenolysis.…”

Section: Metabolic Responsescontrasting

confidence: 69%

Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol.

McLeod¹,

Brown²,

Kuhn³

et al. 1983

Circulation

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SUMMARY The respective contributions of 3-adrenoceptor subtypes to the hemodynamic, humoral and metabolic consequences of adrenergic stimulation during graded exercise in man were investigated using nonselective 8-adrenoceptor blockade with propranolol and ,81-adrenoceptor blockade with atenolol. Doses of these agents that produced comparable suppression of 1,1 response as measured by antagonism of cardioacceleration during exercise were selected. Six healthy, nonsmoking males received these drugs in a placebo-controlled, Latin-square, randomized manner using a double-blind protocol. Both drugs produced comparable reductions of systolic blood pressure and elevation of diastolic blood pressure compared with placebo as exercise load increased. Propranolol produced higher peak epinephrine levels than atenolol or placebo (808 + 162, 640 190 and 584 153 pg/ml, respectively, p = 0.03), but norepinephrine levels did not show significant differences. Plasma renin activity was similarly suppressed both at rest and during all grades of exercise by both drugs. Lactate levels during moderate exercise were significantly lower after propranolol than after either atenolol or placebo (p = 0.03), but were similar at heavy work loads. Plasma glucose values rose on placebo (from 96.5 ± 2.1 to 97.7 2.7 mg/di) and on atenolol (from 99.7 ± 2.2 to 102.1 ± 4.8 mg/dl), but fell on propranolol (from 96.4 1.9 mg/dl to 87.2 ± 2.5 mg/dl, p < 0.01). These results indicate that blockade of vascular smooth muscle 12 receptors does not substantially alter hemodynamics during intense short-term exercise. Stimulation of renin release and lipolysis are produced through /83-adrenoceptor mechanisms, whereas /2 adrenoceptors are important in the provision of carbohydrate as an energy substrate for exercising muscle.

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Section: Metabolic Responsescontrasting

confidence: 69%

Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol.

McLeod¹,

Brown²,

Kuhn³

et al. 1983

Circulation

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show abstract

“…In the present study forearm blood flow remained unchanged after both DL-propranolol and Dpropranolol. In a comparable study intra-arterial infusion of DL-propranolol in a total dose of about 1 mg to healthy subjects produced no change in blood flow during forearm exercise but a reduction in the post-exercise blood flow (Hartling et al, 1980). Arterial blood pressure was not influenced by either isomer.…”

Section: Discussionmentioning

confidence: 78%

“…Forearm blood flow was measured by means of venous occlusion strain-gauge plethysmography at rest and by an indicator-dilution technique after an intra-arterial bolus injection (1·0 ml) of about 2 ,uCi of l3lI-labelled human albumin during forearm exercise (for references see Hartling et al, 1980). Venous occlusion plethysmography could not be used during exercise because of muscular disturbances.…”

Section: Techniquesmentioning

confidence: 99%

“…During exercise, in contrast, limb blood flow can be determined with tolerable precision. In a previous study (Hartling et al, 1980) double measurements of blood flow during forearm exercise were performed with the indicator-dilution technique. There was a resting period of about 1 h between the two measurements, as in the present study.…”

Section: Techniquesmentioning

confidence: 99%

“…Packed cell volume was determined by a centrifugal method. Blood concentrations of glucose and lactate were determined enzymatically and free fatty acids and triglycerides were determined in serum (for references see Hartling et al, 1980).…”

Section: Techniquesmentioning

confidence: 99%

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Systemic and Forearm Haemodynamic and Metabolic Effects of Racemic Propranolol or d-Propranolol in Healthy Subjects

Trap‐Jensen

1981

Clinical Science

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1. The immediate haemodynamic and metabolic effects of intravenous administration of DL-propranolol and D-propranolol were studied in healthy male subjects at rest and during dynamic forearm exercise. The dose of DL-propranolol and of D-propranolol was 0.1 and 1.0 mg/kg body weight respectively. 2. DL-Propranolol reduced heart rate significantly at rest, during forearm exercise and post-exercise, whereas D-propranolol had a lesser effect on heart rate which was significant only at the end of the exercise period. Arterial blood pressure and forearm blood flow were unchanged after either drug. 3. Both drugs reduced the release of lactate from the exercising forearm. Forearm exchange of oxygen, glucose, free fatty acids and triglycerides remained unchanged. 4. The arterial blood glucose concentration increased after D-propranolol, but was unchanged after DL-propranolol. The arterial serum free fatty acid concentration decreased after DL-propranolol, but was not changed after D-propranolol. Arterial concentrations of lactate and triglycerides were not influenced by the drugs. 5. The chronotropic response to beta-adrenoceptor blockade appears to be stereoselective, suggesting specific blockade of beta-adrenoceptors. Metabolic responses to beta-adrenoceptor blockade are difficult to explain in terms of the known adrenoceptor system and may be due to non-specific actions of beta-adrenoceptor antagonists. An exception is inhibition of lipolysis, which is probably mediated via beta-adrenoceptors.

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Integration of Central and Peripheral Regulation of the Circulation during Exercise: Acute and Chronic Adaptations

Mueller

Clifford

Crandall

et al. 2017

Comprehensive Physiology

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Physical movement lasting any more than a few seconds (e.g., exercise), requires coordination of motor control with concomitant changes in the cardiovascular and respiratory support necessary to respond to the rapid increases in metabolic demand. Without such coordination, delivery of oxygen and removal of waste products become rate limiting and will restrict the duration, speed, and quality of movement. Fortunately, under healthy conditions, the central and peripheral nervous systems contribute importantly to this remarkable level of coordination via complex mechanisms that remain to be fully elucidated. The purposes of this review are to present the current state of knowledge regarding: (i) mechanisms by which the body maintains appropriate perfusion pressure to all organs during acute bouts of exercise, and (ii) alterations occurring in these mechanisms via central nervous system adaptations when exercise is performed or not performed on a regular basis (e.g., physically active versus sedentary lifestyle, respectively). Results from studies performed in humans and laboratory animals provide the reader a well-rounded knowledge base. They are intended to instill an appreciation of what is known, and not known, about how the brain regulates the cardiovascular system during acute bouts of exercise, and the adaptations that occur when individuals exercise regularly versus when chronically sedentary. Discussion of the latter is intended to provide novel mechanisms for the increased incidence of cardiovascular disease in sedentary individuals versus a reduced incidence in individuals who are regularly active. © 2018 American Physiological Society. Compr Physiol 8:103-151, 2018.

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Selective and Non-Selective β-Adrenoreceptor Blockade in the Human Forearm

Cited by 42 publications

References 13 publications

Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol.

Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol.

Systemic and Forearm Haemodynamic and Metabolic Effects of Racemic Propranolol or d-Propranolol in Healthy Subjects

Integration of Central and Peripheral Regulation of the Circulation during Exercise: Acute and Chronic Adaptations

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