Selective amidoalkylation of cyclic enamino ketones with N-acyliminium salts of 3,4-dihydroisoquinolines

Alkylative coupling of enaminones and benzimidazole

“…14 We have previously used adducts of cyclic imines and acyl chlorides as electrophilic reagents in an intermolecular α-amidoalkylation reaction toward aromatics and methylene active carbonyl compounds. [15][16][17][18] Now the same strategy has been successfully applied for coupling of benzimidazole and cyclic enaminones. Scheme 1.…”