Abstract:Prostaglandin Ex analogs 5a and 5b, having methyl and ethyl groups as the co-chain, were synthesized by a two-step alkylation system of diethyl 3-oxoglutarate (1) and their six-membered ring analogs 8a and 8b also derived from the first alkylation product 2 via a Michael reaction.We have been active in utilizing diethyl 3-oxoglutarate(1), DEOG, as a convenient synthetic material for the synthesis of a wide variety of compounds including natural products, because DEOG would produce useful intermediates to synth… Show more
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