Selective activation of the mesocortical DA system by stress

Thierry, Anne‐Marie; Tassin, Jean‐Pol; Blanc, G.; Głowiński, J.

doi:10.1038/263242a0

Cited by 1,011 publications

(346 citation statements)

References 13 publications

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“…These single-unit findings are consistent with the large body of data from microdialysis and voltammetry studies that show that levels of DA release within the prefrontal cortex and nucleus accumbens are elevated under both appetitive [13,32,51] and aversive conditions [13,75,110,113]. A primary aim below is to provide a framework that accounts both for the promiscuous DA response to salient events [57,99] and for the large body of evidence showing that DA disruptions attenuate the impact of rewards (and punishers) on several aspects of behavior and learning [1,29,35,38,58,60,76,100,129].…”

Section: Da Neurons Respond To Salient Unexpected Eventssupporting

confidence: 87%

Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum

Horvitz

2002

Behavioural Brain Research

186

148

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Section: Da Neurons Respond To Salient Unexpected Eventssupporting

confidence: 87%

Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum

Horvitz

2002

Behavioural Brain Research

186

148

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“…DA efflux in the mPFC has long been known to be responsive to stress (Thierry et al, 1976). DA efflux in the mPFC is increased during exposure to a wide variety of stressors including footshock (Sorg and Kalivas, 1993;Yoshioka et al, 1996), tail pinch (Finlay et al, 1995), cat odor (Sullivan and Gratton, 1998), and novelty (Davis et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Stressor Controllability Modulates Stress-Induced Dopamine and Serotonin Efflux and Morphine-Induced Serotonin Efflux in the Medial Prefrontal Cortex

Bland

Hargrave

Pepin

et al. 2003

Neuropsychopharmacol

133

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It has previously been shown that inescapable (IS) but not escapable (ES) stress potentiates the rewarding properties of morphine as measured by conditioned place preference and psychomotor activation, and that this potentiation may be mediated by dorsal raphe nucleus (DRN) serotonin (5-HT) neurons. The medial prefrontal cortex (mPFC) has been implicated in both reward and stress, and is a projection region of the DRN. The mPFC also contains dopaminergic afferents from the ventral tegmental area, which has been the focus of many studies exploring both the rewarding properties of drugs and the aversive properties of stress. The role of the mPFC in stress/ drug reactivity interactions is largely unknown. The present study usedin vivo microdialysis to examine 5-HT and dopamine (DA) efflux in the mPFC of rats during IS, ES or no stress (NS). IS and ES rats received the stressor in yoked pairs. The stressor consisted of tailshocks that could be terminated for both rats by the ES rats. Large increases in 5-HT and DA levels were observed during IS but not ES or NS. DA and 5-HT efflux were also measured 24 h later in the same rats in response to morphine (3 mg/kg) or saline. Sustained increases in 5-HT levels were observed after morphine in rats that had previously received IS but not in rats that had received ES or NS. No changes in DA efflux were observed after morphine. Thus, 5-HT and DA in the mPFC may be involved in stressor controllability effects, and the sensitization of 5-HT neurons by IS extends to the mPFC and to morphine as a challenge.

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“…If these findings were correct, they would suggest that dopaminergic afferents might be providing a non-adaptive hyperinnervation of a subpopulation of GABAergic interneurons, perhaps ones that are intrinsically impaired in schizophrenia. Since dopamine appears to exert an inhibitory effect on cortical GABA cells (Retaux et al 1991), these findings would predict that an excessive release of dopamine under conditions of stress (Thierry et al 1976;Roth et al 1988) could lead to an impairment of GABAergic function and ultimately to a decompensation of the intrinsic circuitry in layer II of anterior cingulate cortex (Benes 1997).…”

Section: Postmortem Evidence For a Gaba Defect In Schizophreniamentioning

confidence: 99%

GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder

Beneš

Berretta

2001

Neuropsychopharmacology

982

643

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Neurons that express the compound, ␥ -aminobutyric acid (GABA), are broadly present throughout the central nervous system, although telencephalic structures, such as the cerebral cortex, show the most abundant quantities of this neurotransmitter (Jones 1987). In the discussion that follows, the anatomy and physiology of various types of GABAergic interneurons in the cortex and hippocampus will be discussed and related to recent postmortem studies implicating this transmitter system in the pathophysiology of schizophrenia and bi- 25 , NO . 1 polar disorder and their treatment with neuroleptic drugs (for more comprehensive reviews on cortical and hippocampal neurons see: Hof et al. 1993;Freund and Buzsaki 1996;Somogyi et al. 1998). NEUROBIOLOGY OF GABAERGIC INTERNEURONSBased on Golgi-impregnation studies, Ramon y Cajal provided the first descriptions of several different morphological subtypes of interneurons in the cerebral cortex and hippocampus (Ramon y Cajal 1893, 1911. In more recent years, it has been shown that, with some overlap, different morphological subtypes also have distinct distributions, connectivity, neurochemistry, and electrophysiological properties (for reviews see Hof et al. 1993;Freund and Buzsaki 1996). It is interesting to note that every segment of a pyramidal neuron, such as the soma, dendritic branches and spines, and the initial axonal segment, receives dense GABAergic synaptic innervation (O'Kusky and Colonnier 1982;Hendry et al. 1983;Houser et al. 1983; Beaulieu et al. 1992; for reviews see Jones 1993;Freund and Buzsaki 1996). Even more interestingly, each of these segments appears to be innervated by distinct GABAergic neuronal subtypes (see below).These differences strongly suggest that each of these subtypes plays a fundamentally different role in physiological and pathological mechanisms. In the discussion that follows, cortical interneurons will be described first, since our most basic understanding of GABAergic cells is derived from these populations. In more recent years, however, similar characterizations of interneurons in hippocampus have emerged. Although these cells show some striking similarities to their cortical counterparts, there are also some unique features that distinguish them. For this reason, interneurons in the hippocampus are discussed separately. Cortex Neuroanatomical Studies of Cortical Interneurons.Various types of GABAergic neurons can be categorized according to the type of synaptic profiles they are associated with, as this has direct implications for understanding the physiological role of these cells in cortical circuits. These categories are discussed below.A XO -S OMATIC I NHIBITORY S YNAPSES (B ASKET C ELLS ). The most commonly encountered interneurons ( Figure 1A) are multipolar in shape, i.e., they may have three or more primary dendritic branches emanating from their cell bodies, some having somata that are as large as those of pyramidal neurons (Jones and Hendry 1984). Using immunocytochemistry to localize the enzyme ). These cells also ...

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Selective activation of the mesocortical DA system by stress

Cited by 1,011 publications

References 13 publications

Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum

Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum

Stressor Controllability Modulates Stress-Induced Dopamine and Serotonin Efflux and Morphine-Induced Serotonin Efflux in the Medial Prefrontal Cortex

GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder

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