Selective Activation of Neuronal Targets With Sinusoidal Electric Stimulation

Freeman, Darren; Eddington, Donald K.; Rizzo, Joseph F.; Fried, Shelley I.

doi:10.1152/jn.00551.2010

Cited by 137 publications

(155 citation statements)

References 58 publications

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“…In a comparison between 20 Hz sinusoidal and square-wave stimulation, square-wave thresholds were 22.8±35.5% higher, lending further credence to reports that sine wave stimulation preferentially elicits responses in RGCs whilst avoiding axonal activation (12,13). A subsequent human psychophysical comparison suggested that percepts to sinusoidal stimulation were round and confined, in contrast to the elongated arcs perceived with squarewave stimulation.…”

supporting

confidence: 64%

Are long stimulus pulse durations the answer to improving spatial resolution in retinal prostheses?

Petoe

Shivdasani

2016

Ann. Transl. Med.

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Retinal prostheses can provide artificial vision to patients with degenerate retinae by electrically stimulating the remaining inner retinal neurons. The evoked perception is generally adequate for light localization, but of limited spatial resolution owing to the indiscriminate activation of multiple retinal cell types, leading to distortions in the perceived image. Here we present a perspective on a recent work by Weitz and colleagues who demonstrate a focal confinement of retinal ganglion cell (RGC) activation when using extended pulse durations in the stimulation waveform. Using real-time calcium imaging, they provide evidence that long pulse durations selectively stimulate inner retinal neurons, whilst avoiding unwanted axonal activations. The application of this stimulation technique may provide enhanced spatial resolution for retinal prosthesis users. These experiments provide a robust analysis of the effects of increasing pulse duration and introduce the potential for alternative stimulation paradigms in retinal prostheses.

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supporting

confidence: 64%

Are long stimulus pulse durations the answer to improving spatial resolution in retinal prostheses?

Petoe

Shivdasani

2016

Ann. Transl. Med.

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“…This point should be clarified in future studies with the application of more specific frequency ranges (e.g., 40 -60 Hz vs 80 -100 Hz). In this respect, studies have shown that different classes of neurons are activated at different frequencies (Freeman et al, 2010). Because different cortical areas contain different neuronal types, a specific band of frequencies might lead to the response of a subpopulation of neurons.…”

Section: Discussionmentioning

confidence: 99%

Random Noise Stimulation Improves Neuroplasticity in Perceptual Learning

Fertonani¹,

Pirulli²,

Miniussi³

2011

J. Neurosci.

311

329

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Perceptual learning is considered a manifestation of neural plasticity in the human brain. We investigated brain plasticity mechanisms in a learning task using noninvasive transcranial electrical stimulation (tES). We hypothesized that different types of tES would have varying actions on the nervous system, which would result in different efficacies of neural plasticity modulation. Thus, the principal goal of the present study was to verify the possibility of inducing differential plasticity effects using two tES approaches [i.e., direct current stimulation (tDCS) and random noise stimulation (tRNS)] during the execution of a visual perceptual learning task.One hundred seven healthy volunteers participated in the experiment. High-frequency tRNS (hf-tRNS, 100 -640 Hz), low-frequency tRNS (lf-tRNS, 0.1-100 Hz), anodal-tDCS (a-tDCS), cathodal-tDCS (c-tDCS), and sham stimulation were applied to the visual areas of the brain in a group of volunteers while they performed an orientation discrimination task. Furthermore, a control group was stimulated on the vertex (Cz). The analysis showed a learning effect during task execution that was differentially modulated according to the stimulation conditions. Post hoc comparisons revealed that hf-tRNS significantly improved performance accuracy compared with a-tDCS, c-tDCS, sham, and Cz stimulations.Our results confirmed the efficacy of hf-tRNS over the visual cortex in improving behavioral performance and showed its superiority in comparison to others tES. We concluded that the mechanism of action of tRNS was based on repeated subthreshold stimulations, which may prevent homeostasis of the system and potentiate task-related neural activity. This result highlights the potential of tRNS and advances our knowledge on neuroplasticity induction approaches.

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“…Only a few authors suggest stimulation by sinusoidal and conventional waveforms [9]- [11]. Reported TES does not use biological waveforms or typical membrane potential to stimulate.…”

Section: Methodsmentioning

confidence: 99%