Selective Action of N-Arachidonoyl Dopamine on Viability and Proliferation of Stromal Cells from Eutopic and Ectopic Endometrium

Ashba, A. M.; Yushina, M. N.; Fedorova-Gogolina, I. A.; Gretskaya, N. M.; Безуглов, В. В.; Melkumyan, A. G.; Павлович, С. В.; Bobrov, M. Yu.

doi:10.1007/s10517-019-04456-6

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…There is also a possible role of the endocannabinoid system in regulating endometrial cell proliferation and invasion. 11,12 Some evidence suggests AEA levels may be higher in the peritoneal fluid of women with endometriosis versus disease free women, with a possible correlation with disease severity suggesting a role in the pathogenesis of the disease and symptom manifestation. Several studies have also been conducted looking at the expression of cannabinoid receptors in tissue samples from women with endometriosis versus healthy controls.…”

Section: The Endocannabinoid System and The Reproductive Systemmentioning

confidence: 99%

Cannabidiol for the Management of Endometriosis and Chronic Pelvic Pain

Mistry

Simpson

Morris

et al. 2022

Journal of Minimally Invasive Gynecology

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Section: The Endocannabinoid System and The Reproductive Systemmentioning

confidence: 99%

Cannabidiol for the Management of Endometriosis and Chronic Pelvic Pain

Mistry

Simpson

Morris

et al. 2022

Journal of Minimally Invasive Gynecology

View full text Add to dashboard Cite

show abstract

“…There are few studies evaluating the direct effects of endocannabinoids on cells from endometriosis lesions. The toxic effect on endometriotic stromal cell viability was recently shown for endocannabinoid-related lipid N -arachidonoyl dopamine, but the cell death mechanisms were not investigated [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

N-Acyl Dopamines Induce Apoptosis in Endometrial Stromal Cells from Patients with Endometriosis

Gamisonia

Yushina

Fedorova-Gogolina

et al. 2021

IJMS

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Endometriosis is characterized by the formation and development of endometrial tissues outside the uterus, based on an imbalance between proliferation and cell death, leading to the uncontrolled growth of ectopic foci. The potential target for the regulation of these processes is the endocannabinoid system, which was found to be involved in the migration, proliferation, and survival of tumor cells. In this paper, we investigated the effect of endocannabinoid-like compounds from the N-acyl dopamine (NADA) family on the viability of stromal cells from ectopic and eutopic endometrium of patients with ovarian endometriosis. N-arachidonoyldopamine, N-docosahexaenoyldopamine, and N-oleoyldopamine have been shown to have a five-times-more-selective cytotoxic effect on endometrioid stromal cells. To study the mechanisms of the toxic effect, inhibitory analysis, measurements of caspase-3/9 activity, reactive oxygen species, and the mitochondrial membrane potential were performed. It was found that NADA induced apoptosis via an intrinsic pathway through the CB1 receptor and downstream serine palmitoyltransferase, NO synthase activation, increased ROS production, and mitochondrial dysfunction. The higher selectivity of NADA for endometriotic stromal cells and the current lack of effective drug treatment can be considered positive factors for further research of these compounds as possible therapeutic agents against endometriosis.

show abstract

Selective Action of N-Arachidonoyl Dopamine on Viability and Proliferation of Stromal Cells from Eutopic and Ectopic Endometrium

Cited by 2 publications

References 9 publications

Cannabidiol for the Management of Endometriosis and Chronic Pelvic Pain

Cannabidiol for the Management of Endometriosis and Chronic Pelvic Pain

N-Acyl Dopamines Induce Apoptosis in Endometrial Stromal Cells from Patients with Endometriosis

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