Selective aberrant functional connectivity of resting state networks in social anxiety disorder

Liao, Wei; Chen, Huafu; Feng, Yuanbo; Mantini, Dante; Gentili, Claudio; Pan, Zhengyong; Ding, Jingxin; Duan, Xujun; Qiu, Changjian; Lui, Su; Gong, Qiyong; Zhang, Weiwei

doi:10.1016/j.neuroimage.2010.05.010

Cited by 284 publications

(237 citation statements)

References 77 publications

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“…These findings could help explain some of the deficits in the Executive Control Network in the resting-state (Seeley et al, 2007) in SAD populations as previously observed (Liao et al, 2010a). Our study also revealed hyper-connectivity in the ventral/subcallosal ACC with the putamen seeds.…”

Section: Discussionsupporting

confidence: 86%

“…Similar to the results from striatum seeds (specifically, the putamen), enhanced connectivity in supplementary motor regions in the SAD>HC contrast with the centromedial amygdala seed, re-iterate the "motor readiness" in SAD. Previous fcMRI studies (Liao et al, 2010a;Liao et al, 2010b;Hahn et al, 2011;Prater et al, 2013) have not provided adequate consideration to the functional heterogeneity of amygdala and have reported reduced functional connectivity in SAD. Low-resolution (3.75 x 3.75 x 5 mm) EPI employed in these studies could be partly attributed to the mixed findings because of the dominance of physiological noise to resting state time-series at bigger voxel volumes.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, there has been increased interest in elucidating the pathophysiology and neuronal mechanisms underlying SAD, particularly through the use of resting-state functional connectivity MRI (fcMRI) (Biswal et al, 1995). Of the existing fcMRI studies involving SAD populations, a few studies studies Liao et al, 2010a;Liao et al, 2010b;Liao et al, 2011;Qiu et al, 2011) used identical acquisition parameters including low-resolution (3.75 x 3.75 x 5 mm) voxels. Of the remaining studies, one had very limited coil sensitivity to detect Blood Oxygenation Level Dependent (BOLD) signal from subcortical regions (Pannekoek et al, 2012), and two had limited head coverage and/or low resolution (Hahn et al, 2011;Prater et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Hyper-Connectivity of Subcortical Resting-State Networks in Social Anxiety Disorder

et al. 2014

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyper-Connectivity of Subcortical Resting-State Networks in Social Anxiety Disorder

et al. 2014

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“…Although previous studies have demonstrated differences in activation and FC Liao et al, 2010;Prater et al, 2012;Hahn et al, 2011;Klumpp et al, 2012) between SAD and HCs, the current work is the first to use FC (and activation) to discriminate SAD vs HC diagnostic membership. The current approach of combining machine learning with large-scale, condition-dependent FC is more exploratory and data driven in identifying FC differences than previously used techniques such as PPI Analysis, which only assess FC with a single, a priori specified, 'seed' region at a time.…”

Section: Discussionmentioning

confidence: 85%

Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment

Pantazatos

Talati

Schneier

et al. 2013

Neuropsychopharmacol

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Group functional magnetic resonance imaging (fMRI) studies suggest that anxiety disorders are associated with anomalous brain activation and functional connectivity (FC). However, brain-based features sensitive enough to discriminate individual subjects with a specific anxiety disorder and that track symptom severity longitudinally, desirable qualities for putative disorder-specific biomarkers, remain to be identified. Blood oxygen level-dependent (BOLD) fMRI during emotional face perceptual tasks and a new, large-scale and condition-dependent FC and machine learning approach were used to identify features (pair-wise correlations) that discriminated patients with social anxiety disorder (SAD, N ¼ 16) from controls (N ¼ 19). We assessed whether these features discriminated SAD from panic disorder (PD, N ¼ 16), and SAD from controls in an independent replication sample that performed a similar task at baseline (N: SAD ¼ 15, controls ¼ 17) and following 8-weeks paroxetine treatment (N: SAD ¼ 12, untreated controls ¼ 7). High SAD vs HCs discrimination (area under the ROC curve, AUC, arithmetic mean of sensitivity and specificity) was achieved with two FC features during unattended neutral face perception (AUC ¼ 0.88, Po0.05 corrected). These features also discriminated SAD vs PD (AUC ¼ 0.82, P ¼ 0.0001) and SAD vs HCs in the independent replication sample (FC during unattended angry face perception, AUC ¼ 0.71, P ¼ 0.01). The most informative FC was left hippocampus-left temporal pole, which was reduced in both SAD samples (replication sample P ¼ 0.027), and this FC increased following the treatment (post4pre, t (11) ¼ 2.9, P ¼ 0.007). In conclusion, SAD is associated with reduced FC between left temporal pole and left hippocampus during face perception, and results suggest promise for emerging FC-based biomarkers for SAD diagnosis and treatment effects.

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“…Therefore, 31 patients and 32 controls were included in the analysis. Group differences in translation and rotation of head motion were also evaluated according to the following formula 25 :…”

Section: Data Preprocessingmentioning

confidence: 99%

Abnormal Amygdala Resting-State Functional Connectivity in Irritable Bowel Syndrome

Qi¹,

Liu²,

Ke³

et al. 2016

AJNR Am J Neuroradiol

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Selective aberrant functional connectivity of resting state networks in social anxiety disorder

Cited by 284 publications

References 77 publications

Hyper-Connectivity of Subcortical Resting-State Networks in Social Anxiety Disorder

Hyper-Connectivity of Subcortical Resting-State Networks in Social Anxiety Disorder

Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment

Abnormal Amygdala Resting-State Functional Connectivity in Irritable Bowel Syndrome

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