Selection of subpopulations resistant to amikacin and netilmicin of gentamicin-resistant clinical strains of Staphylococcus aureus and Staphylococcus epidermidis

García, Milagros Torres; Tejedor-Junco, María Teresa; Martín, Margarita Rosa González; Lama, Zoilo González

doi:10.1016/s0934-8840(96)80154-x

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…Plasmid‐borne resistance to aminoglycosides, streptothricins, and aminocyclitols is based on a variety of different resistance genes that code for inactivating enzymes with specific substrate spectra 47,48 . The gene aacA–aphD codes for a bifunctional enzyme of 479 aa with acetyltransferase and phosphotransferase functions that confers resistance to gentamicin, kanamycin, tobramycin, and, when overexpressed, to amikacin 49,50 . The gene aadD codes for the 256 aa adenyltransferase AadD—also known as Aad(4′, 4″)—which confers resistance to kanamycin, neomycin, and tobramycin, 47,51 whereas the gene aphA3 codes for a 264 aa phosphotransferase that mediates resistance to kanamycin, neomycin, and amikacin 47,52 .…”

Section: Plasmid‐borne Genes That Confer Resistance To Pbismentioning

confidence: 99%

Plasmid‐mediated resistance to protein biosynthesis inhibitors in staphylococci

Schwarz

Feßler

Hauschild

et al. 2011

Annals of the New York Academy of Sciences

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Protein biosynthesis inhibitors (PBIs) represent powerful antimicrobial agents for the control of bacterial infections. In staphylococci, numerous resistance genes are known to be involved in resistance to PBIs, most of which mediate resistance to a specific class/subclass of PBIs, though a few genes do confer a multidrug resistance phenotype-up to five classes/subclasses of PBIs. Plasmids play a key role in the dissemination of PBI resistance among staphylococci, as they primarily carry plasmid-borne PBI resistance genes; however, plasmids also can be vectors for transposon-borne PBI resistance genes. Small plasmids that carry single PBI resistance genes are widespread among staphylococci of human and animal origin. Various mechanisms exist by which they can recombine, form cointegrates, or integrate into chromosomal DNA or larger plasmids. We provide an overview of the current knowledge of plasmid-mediated PBI resistance in staphylococci, with particular reference to the currently known PBI resistance genes, their association with mobile genetic elements, and the recombination/integration processes that control their mobility.

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Section: Plasmid‐borne Genes That Confer Resistance To Pbismentioning

confidence: 99%

Plasmid‐mediated resistance to protein biosynthesis inhibitors in staphylococci

Schwarz

Feßler

Hauschild

et al. 2011

Annals of the New York Academy of Sciences

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RETRACTED ARTICLE: Comparison of Topical 0.3% Ofloxacin to Fortified Tobramycin – Cefazolin in the Therapy of Bacterial Keratitis

2000

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Identification and Antimicrobial Susceptibility of Coagulase Positive Staphylococci Isolated from Healthy Dogs and Dogs Suffering from Otitis Externa

Tejedor-Junco

Barrasa

2002

Journal of Veterinary Medicine, Series B

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A total of 67 strains of coagulase positive staphylococci isolated from healthy dogs and dogs suffering from otitis externa were studied. Twenty-two isolates were from healthy dogs (five from hound dogs and 17 from companion dogs) and 45 from dogs suffering otitis externa (14 from hound dogs and 31 from companion dogs). Presumptive identification was attempted using the following tests: production of acetoin, anaerobic utilization of mannitol, acid production from mannitol, presence of beta-galactosidase, and growth on P agar supplemented with different concentrations of acriflavine. Susceptibility of staphylococci to 16 antibiotics was determined. Most effective antibiotics were imipenem, amoxycillin/clavulanic acid, ciprofloxacin, tobramycin, gentamicin and marbofloxacin. Penicillin, ampicillin and polymyxin B showed the lowest activity. There were no significant differences in antimicrobial susceptibility among isolates from healthy dogs and dogs suffering from otitis externa.

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Selection of subpopulations resistant to amikacin and netilmicin of gentamicin-resistant clinical strains of Staphylococcus aureus and Staphylococcus epidermidis

Cited by 6 publications

References 16 publications

Plasmid‐mediated resistance to protein biosynthesis inhibitors in staphylococci

Plasmid‐mediated resistance to protein biosynthesis inhibitors in staphylococci

RETRACTED ARTICLE: Comparison of Topical 0.3% Ofloxacin to Fortified Tobramycin – Cefazolin in the Therapy of Bacterial Keratitis

Identification and Antimicrobial Susceptibility of Coagulase Positive Staphylococci Isolated from Healthy Dogs and Dogs Suffering from Otitis Externa

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