Selection of streptococcal glucan-binding protein C specific DNA aptamers to inhibit biofilm formation
Ákos Harkai,
Yoon Kee Beck,
Anna Tory
et al.
Abstract:Streptococcus mutans is a commensal bacterium in the oral cavity, but its overgrowth leads to biofilm formation and dental caries. S. mutans glucan-binding protein C (GbpC) is a cornerstone of the biofilm scaffold and thus a rational target for biofilm inhibition. Here we present a selection of DNA aptamers for GbpC to aid in the development of biofilm inhibiting drugs. During SELEX, we used the extracellular domain of GbpC as the target of selection and the structurally homologous antigen I/II protein and a G… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.