Selection of high efficient transdermal lipid vesicle for curcumin skin delivery

Lu, Cui-Tao; Zhang, Yi; Xiao, Jian; Zhao, Ying‐Zheng; Tian, Jilai; Xu, Yujuan; Zhang, Feng; Xu, Chongyong

doi:10.1016/j.ijpharm.2013.06.052

Cited by 96 publications

(51 citation statements)

References 27 publications

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“…The abovementioned data suggested that ethanol injection method for the preparation of CUR liposomes was simple and practical. Zhao et al 69 have developed propylene glycol liposomes (PGL) as CUR carriers for skin delivery using ethanol injection method. The mean particle size of CUR-PGL was 182.4±89.2 nm compared with CUR liposomes (632.9±184.1 nm).…”

Section: Solvent Injection Methodsmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

304

208

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Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

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Section: Solvent Injection Methodsmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

304

208

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“…The effects of Tween 80 on the ethosomal system are mainly due to its solubilizing property and the prevention of vesicle fusion. 17,19,24,27,70 Shen et al used Tween 60 in the formulation of transethosomes of artesunate and febrifugine. However, the formulations were unstable, as needle crystals formed in the formula after 5 days.…”

Section: Tweens and Spansmentioning

confidence: 99%

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

313

215

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Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone extensive research since they were invented in 1996; new compounds were added to their initial formula, which led to the production of new types of ethosomal systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, ethosomal dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in dermal/transdermal delivery, in addition to clinical trials. This article provides a detailed review of the ethosomal systems and categorizes them on the basis of their constituents to classical ethosomes, binary ethosomes, and transethosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, ζ-potential (zeta potential), entrapment efficiency, skin-permeation properties, and stability. This paper gives a detailed review on the effects of ethosomal system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the novel pharmaceutical dosage forms of ethosomal gels, patches, and creams are highlighted. The article also provides detailed information regarding the in vivo studies and clinical trials conducted for the evaluation of these vesicular systems.

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“…However, optimization of concentration of ethanol in ethosomal systems is somewhat obligatory in terms of vesicle size, entrapment efficiency, stability, safety, etc. A wide range of investigational studies have reported 30-40% as an optimal range of ethanol in the development of stable and successful ethosomes (Limsuwan & Amnuaikit, 2012;Chiu et al, 2013;Zhao et al, 2013). Studies have reported the increment in the size of vesicle by ethanol concentration range of 20-45% Elsayed et al, 2007) etc.…”

Section: Alcohol and Effects Of Its Elevated Concentrationsmentioning

confidence: 99%

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Pandey¹,

Golhani²,

Shukla³

2014

Drug Delivery

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Delivery across skin is attractive due to its easy accessibility. However, drug delivery across skin is still a challenge in biomedical sciences. Over the past few decades, various successful novel devices and techniques have emerged to optimize drug delivery across skin whose obstructing behavior constricts entry of most of the therapeutic agents. Inability of various conventional vesicular formulations, e.g. liposomes to pass through the tapered (430 nm) intercellular channels of stratum corneum, rendered invention of some lipid based vesicular carrier systems such as ethosomes which consist of phospholipid, ethanol and water. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. In spite of their sophistication in conceptuality, they are exemplified by easiness in their preparation, safety and efficacy -a combination that can highly inflate their application. This review attempts to describe all aspects of ethosomes including roles and upshots of different excipients, various methods of preparation and characterizations, research reports on various drug deliveries, patent reports and future prospects.

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Selection of high efficient transdermal lipid vesicle for curcumin skin delivery

Cited by 96 publications

References 27 publications

Liposomal curcumin and its application in cancer

Liposomal curcumin and its application in cancer

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

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