Selection of Endogenous Control Reference Genes for Studies on Type 1 or Type 2 Endometrial Cancer

Ayakannu, Thangesweran; Taylor, Anthony H.; Konje, Justin C.

doi:10.1038/s41598-020-64663-4

Cited by 18 publications

(21 citation statements)

References 37 publications

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“…PSMC4 and PSMC5 contribute to prostate tumorigenesis [ 35 ]. Additionally, PSMC4 was identified as one of the best biomarkers for endometrial cancer [ 36 ], and risk model construction revealed that it is also a prognostic marker for the same type of cancer [ 37 ]. PSMC5 acts as a novel regulator and is involved in the extracellular signal-regulated kinase 1/2 signaling pathway [ 38 ], and it was observed to have a relatively higher cytoplasmic expression pattern in most cancer types [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer

Kao

Phan

et al. 2021

Aging

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Breast cancer is a complex disease, and several processes are involved in its development. Therefore, potential therapeutic targets need to be discovered for these patients. Proteasome 26S subunit, ATPase gene (PSMC) family members are well reported to be involved in protein degradation. However, their roles in breast cancer are still unknown and need to be comprehensively researched. Leveraging publicly available databases, such as cBioPortal and Oncomine, for high-throughput transcriptomic profiling to provide evidence-based targets for breast cancer is a rapid and robust approach. By integrating the aforementioned databases with the Kaplan–Meier plotter database, we investigated potential roles of six PSMC family members in breast cancer at the messenger RNA level and their correlations with patient survival. The present findings showed significantly higher expression profiles of PSMC2, PSMC3, PSMC4, PSMC5, and PSMC6 in breast cancer compared to normal breast tissues. Besides, positive correlations were also revealed between PSMC family genes and ubiquinone metabolism, cell cycle, and cytoskeletal remodeling. Meanwhile, we discovered that high levels of PSMC1, PSMC3, PSMC4, PSMC5, and PSMC6 transcripts were positively correlated with poor survival, which likely shows their importance in breast cancer development. Collectively, PSMC family members have the potential to be novel and essential prognostic biomarkers for breast cancer development.

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Section: Discussionmentioning

confidence: 99%

Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer

Kao

Phan

et al. 2021

Aging

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“…MRPs have a significant effect in female-specific cancers. MRPL19 is one of the internal reference genes for type I or II endometrial cancers and the expression level of MRPL46 had the greatest influence on the prognosis of ovarian cancer [ 19 , 20 , 49 ]. Overexpression of MRPS18-B (MRPS18-2) leads to the epithelial cells that acquire a higher migration ability to transform as mesenchymal cell (EMT).…”

Section: Mrps Associated With Cancersmentioning

confidence: 99%

“…Endometrial cancers [19,20], Diffuse non-Hodgkin lymphoma [21], Melanoma [22] MRPL21 bL21m Acute myeloid leukemia [23] ↑…”

Section: Mrpl19 Bl19mmentioning

confidence: 99%

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Huang

Zhang

2020

IJMS

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Mammalian mitochondrial ribosomes translate 13 proteins encoded by mitochondrial genes, all of which play roles in the mitochondrial respiratory chain. After a long period of reconstruction, mitochondrial ribosomes are the most protein-rich ribosomes. Mitochondrial ribosomal proteins (MRPs) are encoded by nuclear genes, synthesized in the cytoplasm and then, transported to the mitochondria to be assembled into mitochondrial ribosomes. MRPs not only play a role in mitochondrial oxidative phosphorylation (OXPHOS). Moreover, they participate in the regulation of cell state as apoptosis inducing factors. Abnormal expressions of MRPs will lead to mitochondrial metabolism disorder, cell dysfunction, etc. Many researches have demonstrated the abnormal expression of MRPs in various tumors. This paper reviews the basic structure of mitochondrial ribosome, focuses on the structure and function of MRPs, and their relationships with cell apoptosis and diseases. It provides a reference for the study of the function of MRPs and the disease diagnosis and treatment.

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“…mRNA is a single-stranded molecule of RNA that is complementary to the genetic sequence of a gene and has been commonly used as a biomarker for early detection and treatment of cancer due to its humoral stability and biological regulatory function. It is usually quantitatively detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) [35][36][37]. Although qRT-PCR is a very sensitive method, it is timeconsuming and requires heavy instruments for the associated thermocycling reactions.…”

Section: Messenger Rna (Mrna)mentioning

confidence: 99%

Nanomaterial-Based Fluorescence Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) to Detect Nucleic Acid in Cancer Diagnosis

Choi

Shin

et al. 2021

Biomedicines

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Nucleic acids, including DNA and RNA, have received prodigious attention as potential biomarkers for precise and early diagnosis of cancers. However, due to their small quantity and instability in body fluids, precise and sensitive detection is highly important. Taking advantage of the ease-to-functionality and plasmonic effect of nanomaterials, fluorescence resonance energy transfer (FRET) and metal-enhanced fluorescence (MEF)-based biosensors have been developed for accurate and sensitive quantitation of cancer-related nucleic acids. This review summarizes the recent strategies and advances in recently developed nanomaterial-based FRET and MEF for biosensors for the detection of nucleic acids in cancer diagnosis. Challenges and opportunities in this field are also discussed. We anticipate that the FRET and MEF-based biosensors discussed in this review will provide valuable information for the sensitive detection of nucleic acids and early diagnosis of cancers.

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Selection of Endogenous Control Reference Genes for Studies on Type 1 or Type 2 Endometrial Cancer

Cited by 18 publications

References 37 publications

Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer

Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Nanomaterial-Based Fluorescence Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) to Detect Nucleic Acid in Cancer Diagnosis

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