Selection of catalyst for commercial production of 12-hydroxystearic acid ?a saponifiable base for greases

Maskaev, A. K.; Simurova, E. I.; Man'kovskaya, N. K.

doi:10.1007/bf00717239

Cited by 1 publication

(2 citation statements)

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“…The catalytic hydrogenation of castor oil to 12-Hydroxystearic Acid has also been reported (Mankovskaya et al 1970;Maskaev, Simurova, and Mankovskaya 1973). This reaction also yielded small amounts of ricinoleic acid, stearic acid, oleic acid, palmitic acid, arachidic acid, and traces of linolenic acid and linoleic acid (Mankovskaya et al 1970).…”

Section: Figurementioning

confidence: 84%

“…Noncosmetic Use 12-Hydroxystearic Acid has been used as a textile lubricant (Mankovskaya et al 1970) and as a saponifiable base for greases (Maskaev, Simurova, and Mankovskaya 1973). 12-Hydroxystearic Acid-polyethylene glycol block polymers have been approved by FDA for use as surfactants, for dispersion of polyacrylamide retention and draining aids, employed prior to the sheet forming operation in the manufacture of paper and paperboard, that come in contact with aqueous and fatty foods.…”

Section: Hydroxystearic Acidmentioning

confidence: 99%

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Amended Final Report on the Safety Assessment of Hydroxystearic Acid¹

1999

Int J Toxicol

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Hydroxystearic Acid is a fatty acid used as a surfactant–cleansing agent in cosmetic products. Initial review of available safety test data resulted in a finding that there were insufficient data to support the safety of Hydroxystearic Acid for use in cosmetic products. Data needed included concentration of use, chemical characterization, dermal reproductive and developmental toxicity, genotoxicity (and carcinogenicity data if the genotoxicity data were positive), and shin irritation data. Subsequent to that conclusion, new data were received. Use concentrations were reported as high as 10%. Small amounts of other fatty acids are commonly found in preparations of Hydroxystearic Acid. Genotoxicity was not found in bacterial or mammalian systems and only subcutaneous sarcomas at the site of injection were found in carcinogenicity studies. Dermal reproductive and developmental toxicity studies were negative. Skin irritation was produced by antiperspirant prototype formulations containing Hydroxystearic Acid under occluded or semioccluded patch test conditions. It was considered that such formulations under those exaggerated conditions can be irritating, but are generally not irritating in actual use. Because Hydroxystearic Acid and Stearic Acid are structurally similar, data from a previous safety assessment of Oleic Acid, Lauric Acid, Palmitic Acid, Myristic Acid, and Stearic Acid were summarized. On the basis of the animal and clinical data, it was concluded that Hydroxystearic Acid is safe as a cosmetic ingredient in the present practices of use.

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Section: Figurementioning

confidence: 84%

Section: Hydroxystearic Acidmentioning

confidence: 99%