Abstract:A major hurdle in drug development is the limited benefit of efficacy data in animals for use in the clinic. For each patient (sub)group or disease, many different animal models exist to provide insight into drug efficacy. However, it is often unclear how predictive the outcomes of drugs tested in these models are for the clinic, and on what basis researchers select a specific model. The main goal of this thesis is to gain insight into the selection of animal models for drug efficacy. We studied the extent of … Show more
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