Selection for high and low oxygen consumption altered hepatic mitochondrial energy efficiency in mice

Yu, Hong; Ardiyanti, Astrid; Kikusato, Motoi; Shimazu, Tomoyuki; Toyomizu, Masaaki; Suzuki, Keiichi

doi:10.1111/asj.12366

Cited by 8 publications

(37 citation statements)

References 18 publications

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“…Furthermore, Hong et al . () confirmed that the FCR of individual feeding of the L‐line mice was significantly greater than that of H‐line mice at the 11th generation. These results confirmed that the selection for high and low OC, which was an indirect index used to measure MER, was a useful selection criterion to improve FCR.…”

Section: Discussionsupporting

confidence: 56%

Selection for high and low oxygen consumption‐induced differences in maintenance energy requirements of mice

Darhan

Kikusato

Toyomizu

et al. 2016

Animal Science Journal

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Maintenance energy requirements (MER) of mice selected for high (H) or low (L) oxygen consumption (OC) were compared. Forty-four mice from H and L OC lines were weaned at 3 weeks and divided into four experimental groups: group A were sacrificed at 4 weeks; group B were fed ad libitum, and groups C and D were fed 2.8 and 2.4 g/day, respectively, from 4 to 8 weeks of age. Groups B-D were sacrificed at 8 weeks. Chemical components were estimated for all groups. MER was estimated using a model that partitioned metabolizable energy intake into that used for maintenance, and protein and fat deposition. The feed conversion ratio for the B group was significantly higher in the H than in the L line. Feed intake for metabolic energy content per metabolic body size was significantly also higher in the H line, whereas accumulated energy content per metabolic body size was significantly higher in the L line. MER of the H line was greater than that of the L line (P < 0.10). These results suggest that selection for H or L OC produced differences in chemical components, feed efficiency, and MER between the H and L lines.

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Section: Discussionsupporting

confidence: 56%

Selection for high and low oxygen consumption‐induced differences in maintenance energy requirements of mice

Darhan

Kikusato

Toyomizu

et al. 2016

Animal Science Journal

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“…The results obtained for MH and ML were similar to those determined for high and low OC because all of them were all directly or indirectly selected based on their MER. In the presence of succinic acid substrate, the liver mitochondrial proton leak was significantly higher for the H line than the L line as previously reported (Hong et al, ). Proton leak is the mitochondrial respiration rate in the presence of an ATP synthase inhibitor and reflects state 4 respiration (Divakaruni & Brand, ).…”

Section: Discussionsupporting

confidence: 87%

“…Significant differences in FCR (Hong et al, ,) and MER (Darhan et al, ) between the H and L mouse lines were previously reported. In the present study, RFI was calculated from FI measurements in 37 mice of the 16th generation.…”

Section: Discussionmentioning

confidence: 86%

“…Therefore, we selected for both high and low OC and constructed genetically different OC in mice (Hong, Komaki, Shimazu, & Suzuki, 2013). The high and low-OC mice differed in terms of FCR, MER, hepatic mitochondrial respiration activity, and proton leak (Darhan et al, 2017;Hong et al, 2015Hong et al, , 2013. However, the correlations between mitochondrial respiration activity and feed efficiency were not estimated because both parameters must be measured in the same individual.…”

Section: )mentioning

confidence: 99%

“…In complex II, then, the amount of energy allocated to the electron transfer system is small. In a previous report (Hong et al, ), mitochondrial respiration activity was compared using succinate as a substrate. In the present study, we used both GMP and succinic acid as substrates in the attempt to reconfirm the differences between mouse lines selected for high and low OC in liver mitochondrial respiration.…”

Section: Introductionmentioning

confidence: 99%

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Correlations between mitochondrial respiration activity and residual feed intake after divergent genetic selection for high‐ and low‐ oxygen consumption in mice

Darhan¹,

Zoda

Kikusato³

et al. 2019

Animal Science Journal

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The aims of the present study were to identify the differences between two mouse lines (high (H)‐ and low (L)‐oxygen consumption) in terms of mitochondrial respiratory activity when GMP (glutamate, malate, and pyruvate) and succinic acid are used as substrates and to examine the relationship between mitochondrial respiration activity and feed efficiency in both lines. The average daily feed intake, feed conversion ratio (FCR), and residual feed intake (RFI) were significantly higher in the H than the L line. The correlation between FCR and RFI was significant (r = 0.60, p < 0.05). RFI was effective as an indicator of feed efficiency. When succinic acid was used as a substrate, mitochondrial respiration states 2–4, ACR, and proton leak were significantly higher in the H than the L line. When GMP was used as a substrate, respiration states 3 and 4 in the H line were significantly higher than those in the L line, and there were significant positive correlations between FCR and RFI and mitochondrial respiration states 2–4. The results indicated that selection for high or low OC changed the basal metabolic rates estimated from liver mitochondrial respiration activity and feed efficiency.

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Differences in energy metabolism and mitochondrial redox status account for the differences in propensity for developing obesity in rats fed on high‐fat diet

Sun

et al. 2021

Food Science & Nutrition

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Obesity is a metabolic disease that is accompanied by oxidative stress. Mitochondrial dysfunction is closely associated with the occurrence and development of obesity. However, it is unclear if there are differences in mitochondrial redox homeostasis and energy metabolism between obesity‐prone (OP) and obesity‐resistant (OR) individuals and if these differences account for the different susceptibilities to developing obesity. The present study aimed to compare the regulation of energy metabolism between OP and OR rats during high‐fat diet (HFD)‐induced oxidative stress. Male Sprague Dawley rats were randomly divided into the control group and the HFD group. The HFD group was further divided into the OP and OR groups based on body weight gain (upper 1/3 for OP; lower 1/3 for OR) after eight weeks on HFD. Rats were sacrificed at the 8th and 20th week, and serum and organs were collected. At 8 weeks, HFD decreased mitochondrial antioxidant enzyme activity and increased the production of ROS in the OP rats, which was accompanied by unusual mitochondrial oxidative phosphorylation, reduced mitochondrial membrane potential (MMP), and decreased ATP production. When the feeding period was extended beyond the 8 weeks, the energy expenditure of the OP rats reduced further, resulting in elevated blood lipids and glucose levels and increased body weight. In contrast, the OR rats had higher mitochondrial antioxidant enzyme activity and normal redox homeostasis throughout the period, which was beneficial in energy utilization and ATP production. Thus, the increase in energy expenditure in the OR rats reduced the HFD‐induced weight gain. Mitochondrial function and antioxidant defense might be involved in the different propensities for developing obesity. Consequently, the ability of OR rats to resist obesity may be attributed to their ability to maintain mitochondrial function and redox balance.

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Selection for high and low oxygen consumption altered hepatic mitochondrial energy efficiency in mice

Cited by 8 publications

References 18 publications

Selection for high and low oxygen consumption‐induced differences in maintenance energy requirements of mice

Selection for high and low oxygen consumption‐induced differences in maintenance energy requirements of mice

Correlations between mitochondrial respiration activity and residual feed intake after divergent genetic selection for high‐ and low‐ oxygen consumption in mice

Differences in energy metabolism and mitochondrial redox status account for the differences in propensity for developing obesity in rats fed on high‐fat diet

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