Selection and preliminary application of a single stranded DNA aptamer targeting colorectal cancer serum

Abstract

Aptamer Seq-2 with high affinity and selectivity was screened against colorectal cancer serum directly for clinical application.

Identification of a novel DNA aptamer that selectively targets lung cancer serum

“…Li et al used the acetonitrile precipitation method to remove high-abundance proteins in colorectal cancer serum as the screening target, and obtained its specific aptamers after 10 rounds of SELEX screening. 18 As such, the serum aptamer screening method is effective for developing aptamer-based biosensors selection protocol.…”