“…The predicted stronger escapers (scores > 0.5) are G446S, T478K, E484A, Q493R, G496S, Q498R, N501Y and Y505H and the weaker escapers (scores < 0.5) are G339D, S371L, S373P, S375F, K417N and N440K. Some novel Omicron mutations (G339D, S371L, S373P, S375F, Q493R, G496S, Q498R, and Y505H) are thought to have either a neutral or negative selective advantage 2 . Our modeling indicates that these mutations induce a range of positive antibody escape scores, implying they contribute to the overall fitness of the Omicron variant.…”