Selectins and Associated Adhesion Proteins in Inflammatory disorders

Gupta, Garima

doi:10.1007/978-3-7091-1065-2_44

Cited by 3 publications

(4 citation statements)

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“…In inflammation, neutrophils aggregate and adhere to ECs [39,40]. Initially, P, E, and L selectins participate in the process of adhesion to the endothelium [41]. P-selectin, in particular, performs an important role in diseases associated with damage and thrombosis of blood vessels, selectin initiates the accumulation of leukocytes and adhesion to the endothelium and then in the accumulation of platelets [42].…”

Section: The Role Of Adhesion Proteins and Cytokines In Inflammationmentioning

confidence: 99%

Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

Gwozdzinski,

Pieniazek,

Gwozdzinski

2024

IJMS

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One of the early symptoms of chronic venous disease (CVD) is varicose veins (VV) of the lower limbs. There are many etiological environmental factors influencing the development of chronic venous insufficiency (CVI), although genetic factors and family history of the disease play a key role. All these factors induce changes in the hemodynamic in the venous system of the lower limbs leading to blood stasis, hypoxia, inflammation, oxidative stress, proteolytic activity of matrix metalloproteinases (MMPs), changes in microcirculation and, consequently, the remodeling of the venous wall. The aim of this review is to present current knowledge on CVD, including the pathophysiology and mechanisms related to vein wall remodeling. Particular emphasis has been placed on describing the role of inflammation and oxidative stress and the involvement of extracellular hemoglobin as pathogenetic factors of VV. Additionally, active substances used in the treatment of VV were discussed.

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Section: The Role Of Adhesion Proteins and Cytokines In Inflammationmentioning

confidence: 99%

Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

Gwozdzinski,

Pieniazek,

Gwozdzinski

2024

IJMS

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“…), причем выраженность ассоциированного с НР воспалительного процесса в слизистой оболочке желудка и ДПК коррелирует со степенью эндотелиальной дисфункции [22,23]. Установлена прямая связь между концентрациями L-селектина, ICAM-1, ICAM-2 и тяжестью клинических проявлений при язвенном колите [24][25][26]. Молекулы клеточной адгезии играют важную роль в миграции лейкоцитов из сосудистого русла в слизистую оболочку кишечника, причем особенно высокий уровень при воспалительных заболеваниях кишечника характерен для Е-селектина [26].…”

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“…Установлена прямая связь между концентрациями L-селектина, ICAM-1, ICAM-2 и тяжестью клинических проявлений при язвенном колите [24][25][26]. Молекулы клеточной адгезии играют важную роль в миграции лейкоцитов из сосудистого русла в слизистую оболочку кишечника, причем особенно высокий уровень при воспалительных заболеваниях кишечника характерен для Е-селектина [26]. Показано снижение уровней Р-селектина, Е-селектина, sVCAM-1 после проведенной эффективной терапии воспалительных заболеваний кишечника (язвенный колит, болезнь Крона) [17].…”

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“…Показано снижение уровней Р-селектина, Е-селектина, sVCAM-1 после проведенной эффективной терапии воспалительных заболеваний кишечника (язвенный колит, болезнь Крона) [17]. При других хронических воспалительных заболеваниях, сопровождающихся патологией желудка, также был отмечен повышенный уровень молекул адгезии: ICAM-1 у больных целиакией, ICAM-1 и VCAM при синдроме Бехчета и системной склеродермии [26].…”

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The role of cell adhesion molecules in the inflammatory process and development of gastric and duodenal peptic ulcer disease, their molecular genetic determinants

Рашина

Чурносов

2022

jour

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With gastric and duodenal peptic ulcer disease, a chronic inflammatory process develops, in which cell adhesion molecules are actively involved. Currently, as a result of genome-wide association studies (GWAS), more than 20 polymorphic variants involved in determining their level have been identified, including rs505922 of the ABO gene. At the same time, this polymorphic variant, according to GWAS, is associated with an increased risk of developing peptic ulcer disease (PUD). It should also be noted that the association of the O(I) blood group according to the ABO system with an increased risk of developing PUD has long been known. Therefore, the genetic determinants of cell adhesion molecules are of interest for studying as candidate genes for peptic ulcer disease.

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Mumefural Improves Blood Flow in a Rat Model of FeCl3-Induced Arterial Thrombosis

Bang

Jeon

2020

Nutrients

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Mumefural (MF), a bioactive component of the processed fruit of Prunus mume Sieb. et Zucc, is known to inhibit platelet aggregation induced by agonists in vitro. In this study, we investigated the anti-thrombotic effects of MF using a rat model of FeCl3-induced arterial thrombosis. Sprague–Dawley rats were intraperitoneally injected with MF (0.1, 1, or 10 mg/kg) 30 min before 35% FeCl3 treatment to measure the time to occlusion using a laser Doppler flowmeter and to assess the weight of the blood vessels containing thrombus. MF treatment significantly improved blood flow by inhibiting occlusion and thrombus formation. MF also prevented collagen fiber damage in injured vessels and inhibited the expression of the platelet activation-related proteins P-selectin and E-selectin. Moreover, MF significantly reduced the increased inflammatory signal of nuclear factor (NF)-κB, toll-like receptor 4 (TLR4), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 in blood vessels. After administration, MF was detected in the plasma samples of rats with a bioavailability of 36.95%. Therefore, we suggest that MF may improve blood flow as a candidate component in dietary supplements for improving blood flow and preventing blood circulation disorders.

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Selectins and Associated Adhesion Proteins in Inflammatory disorders

Cited by 3 publications

References 263 publications

Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

The role of cell adhesion molecules in the inflammatory process and development of gastric and duodenal peptic ulcer disease, their molecular genetic determinants

Mumefural Improves Blood Flow in a Rat Model of FeCl3-Induced Arterial Thrombosis

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