Selecting patients for hyperthermia combined with preoperative chemoradiotherapy for locally advanced rectal cancer

Kim, Sangwon; Yea, Ji Woon; Kim, Jae Hwang; Gu, Mi Jin; Kang, Min Kyu

doi:10.1007/s10147-017-1213-z

Cited by 5 publications

(2 citation statements)

References 40 publications

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Section: Clinical Use Of Hyperthermiamentioning

confidence: 99%

“…75 Moreover, several studies have also demonstrated a better local control rate and survival benefit of the combination of preoperative neoadjuvant chemoradiotherapy and hyperthermia than chemoradiotherapy alone for rectal cancer patients. 76,77 In clinical practice, RHT combined with radiochemotherapy has been shown to be an effective sensitizer for chemoradiotherapy, which can be applied in various types of tumors. Chemoradiotherapy is carried out according to clinical guidelines, while hyperthermia is usually performed immediately after RT, once or twice a week.…”

Section: Hyperthermia Combined With Chemoradiotherapymentioning

confidence: 99%

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The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors

Cheng

Weng

et al. 2019

Integr Cancer Ther

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Hyperthermia is often used in combination with chemotherapy and radiotherapy for cancer treatment. Recently, immunotherapy has become a popular research area, breaking exciting new ground with concurrent immunotherapy and hyperthermia. Much evidence has demonstrated the effectiveness of multidisciplinary synergistic therapy, and the underlying mechanism has been gradually explored. In this review, we focus on the mechanism of various cancer treatments in the current literature and recent advances in hyperthermia. Additionally, we review clinical studies of hyperthermia combined with other therapies in the previous 10 years and propose future prospects for hyperthermia in multidisciplinary synergistic therapy.

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Section: Clinical Use Of Hyperthermiamentioning

confidence: 99%

Section: Hyperthermia Combined With Chemoradiotherapymentioning

confidence: 99%

The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors

Cheng

Weng

et al. 2019

Integr Cancer Ther

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Impact of formulation on solid oxygen‐entrapping materials to overcome tumor hypoxia

McGovern,

Witt,

Rhodes

et al. 2024

J Biomedical Materials Res

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Tumor hypoxia, resulting from rapid tumor growth and aberrant vascular proliferation, exacerbates tumor aggressiveness and resistance to treatments like radiation and chemotherapy. To increase tumor oxygenation, we developed solid oxygen gas‐entrapping materials (O2‐GeMs), which were modeled after clinical brachytherapy implants, for direct tumor implantation. The objective of this study was to investigate the impact different formulations of solid O2‐GeMs have on the entrapment and delivery of oxygen. Using a Parr reactor, we fabricated solid O2‐GeMs using carbohydrate‐based formulations used in the confectionary industry. In evaluating solid O2‐GeMs manufactured from different sugars, the sucrose‐containing formulation exhibited the highest oxygen concentration at 1 mg/g, as well as the fastest dissolution rate. The addition of a surface coating to the solid O2‐GeMs, especially polycaprolactone, effectively prolonged the dissolution of the solid O2‐GeMs. In vivo evaluation confirmed robust insertion and positioning of O2‐GeMs in a malignant peripheral nerve sheath tumor, highlighting potential clinical applications.

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Local Therapy Options for Recurrent Rectal and Anal Cancer: Current Strategies and New Directions

Dee

Eyler

Sanford

et al. 2019

Curr Colorectal Cancer Rep

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Selecting patients for hyperthermia combined with preoperative chemoradiotherapy for locally advanced rectal cancer

Abstract: Hyperthermia might selectively enhance the preoperative treatment response in LARC with positive CA9 expression and offset the negative effect of hypoxia on prognosis. Pretreatment evaluation of hypoxia could aid in the selection of patients who might benefit from hyperthermia.

Cited by 5 publications

References 40 publications

The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors

The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors

Impact of formulation on solid oxygen‐entrapping materials to overcome tumor hypoxia

Local Therapy Options for Recurrent Rectal and Anal Cancer: Current Strategies and New Directions

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