Selecting highly sensitive non-obese diabetic mice for improving the study of Sjögren’s syndrome

Xiao, Weibao; Wu, Yalan; Zhang, Jingfa; Ye, Wen; Xu, Guo‐Tong

doi:10.1007/s00417-008-0941-1

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…In addition to being resistant to diabetes, B −/− mice are resistant to many other autoimmune diseases, such as thyroiditis, Sjögren syndrome, arthritis and systemic lupus erythematosus . Some WT NOD mice develop lymphocyte infiltration of salivary glands and thyroid glands characteristic of Sjögren syndrome and thyroiditis . Salivary gland infiltration was significantly increased in Treg‐cell‐depleted B −/− mice compared with controls (Fig.…”

Section: Discussionmentioning

confidence: 92%

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Transient depletion of CD4⁺ CD25⁺ regulatory T cells results in multiple autoimmune diseases in wild‐type and B‐cell‐deficient NOD mice

2013

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SummaryApproximately 80% of female wild-type non-obese diabetic (WT NOD) mice spontaneously develop diabetes, whereas B-cell-deficient (B NOD mice given anti-CD25 developed diabetes much earlier than WT mice given rat IgG, whereas rat IgG-treated B −/− mice did not develop diabetes. Treg-cell-depleted mice had increased lymphocyte infiltration of the pancreas, salivary glands and thyroid compared with controls given rat IgG. These results are consistent with the hypothesis that resistance of B-cell-deficient NOD mice to several autoimmune diseases is due to the activity of Treg cells.

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Section: Discussionmentioning

confidence: 92%

“…14,15 Some WT NOD mice develop lymphocyte infiltration of salivary glands and thyroid glands characteristic of Sj€ ogren syndrome and thyroiditis. [39][40][41][45][46][47][48] Salivary gland infiltration was significantly increased in Treg-cell-depleted B −/− mice compared with controls ( Fig. 4a) (P = 0Á023).…”

Section: Discussionmentioning

confidence: 93%

Transient depletion of CD4⁺ CD25⁺ regulatory T cells results in multiple autoimmune diseases in wild‐type and B‐cell‐deficient NOD mice

2013

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“…In patients with meibomian gland dysfunction MGD and those with Sjogren’s syndrome, compared with normal participants, the concentrations of tear IL-1α and mature IL-1β were increased, and precursor IL-1β was decreased [ 30 ]. Experimentally, the production of IL-1β in tears has been linked to inflammation [ 39 ],[ 40 ],[ 59 ],[ 60 ],[ 114 ],[ 115 ].…”

Section: Reviewmentioning

confidence: 99%

Practical issues concerning tear protein assays in dry eye

D’Souza

Tong

2014

Eye and Vis

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Dry eye is a common clinical condition diagnosed by cumulative evidence of symptoms and signs. Many new treatments in dry eye are either expensive, invasive, have potential for side effects, or are not easily accessible. In severe dry eye, the ideal modality of treatment to begin with is often not clear as specific molecular disturbances are not evident from just examination of clinical manifestations. Assessing the effects of ongoing treatment is not straight forward since there is lack of agreement between clinical signs and symptoms. There is a need to have more objective methods of selecting treatment for dry eye and monitoring the effect of treatment.Recently, there are many new technologies applied to the discovery of tear biomarkers, for e.g., mass spectrometry based proteomics techniques and multiplex assays such as the bead-based sandwich indirect immunofluorescent assays. Tear proteins assays have even been made available as point-of-care devices. This review focuses on the evidence for the involvements of tear proteins in dry eye, possible changes in tear concentrations with therapy and the strength of evidence regarding dry eye pathology. Much remains to be done in terms of developing office-based assays and ascertaining their reliability, but current evidence suggests that tear proteins have a role in the clinical practice of dry eye.

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“…NOD mice are susceptible to the spontaneous development of autoimmune insulin-dependent diabetes mellitus (55). Moreover, it facilitates investigating the influence of autoimmune processes on dry eye syndrome (56,57). Lymphocytic infiltration leads to the degradation of extracellular matrix structures in the lacrimal gland of NOD mice (58).…”

Section: Autoimmune Disease-associated Dry Eye Modelsmentioning

confidence: 99%

Application of Animal Models in Interpreting Dry Eye Disease

Zhu

Inomata

Shih³

et al. 2022

Front. Med.

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Different pathophysiologic mechanisms are involved in the initiation, development, and outcome of dry eye disease (DED). Animal models have proven valuable and efficient in establishing ocular surface microenvironments that mimic humans, thus enabling better understanding of the pathogenesis. Several dry eye animal models, including lacrimal secretion insufficiency, evaporation, neuronal dysfunction, and environmental stress models, are related to different etiological factors. Other models may be categorized as having a multifactorial DED. In addition, there are variations in the methodological classification, including surgical lacrimal gland removal, drug-induced models, irradiation impairment, autoimmune antibody-induced models, and transgenic animals. The aforementioned models may manifest varying degrees of severity or specific pathophysiological mechanisms that contribute to the complexity of DED. This review aimed to summarize various dry eye animal models and evaluate their respective characteristics to improve our understanding of the underlying mechanism and identify therapeutic prospects for clinical purposes.

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Selecting highly sensitive non-obese diabetic mice for improving the study of Sjögren’s syndrome

Abstract: BUT and CTT tests are useful methods in screening high susceptible NOD mice. Cutting lines at BUT < or = 2 seconds and CTT < or = 4 mm/min provide a good balance between the assurance of susceptibility and the maximization of use of NOD mice for the study of Sjögren's syndrome.

Cited by 7 publications

References 23 publications

Transient depletion of CD4⁺ CD25⁺ regulatory T cells results in multiple autoimmune diseases in wild‐type and B‐cell‐deficient NOD mice

Transient depletion of CD4⁺ CD25⁺ regulatory T cells results in multiple autoimmune diseases in wild‐type and B‐cell‐deficient NOD mice

Practical issues concerning tear protein assays in dry eye

Application of Animal Models in Interpreting Dry Eye Disease

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Selecting highly sensitive non-obese diabetic mice for improving the study of Sjögren’s syndrome

Abstract: BUT and CTT tests are useful methods in screening high susceptible NOD mice. Cutting lines at BUT < or = 2 seconds and CTT < or = 4 mm/min provide a good balance between the assurance of susceptibility and the maximization of use of NOD mice for the study of Sjögren's syndrome.

Cited by 7 publications

References 23 publications

Transient depletion of CD4+ CD25+ regulatory T cells results in multiple autoimmune diseases in wild‐type and B‐cell‐deficient NOD mice

Transient depletion of CD4+ CD25+ regulatory T cells results in multiple autoimmune diseases in wild‐type and B‐cell‐deficient NOD mice

Practical issues concerning tear protein assays in dry eye

Application of Animal Models in Interpreting Dry Eye Disease

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Product

Resources

About

Transient depletion of CD4⁺ CD25⁺ regulatory T cells results in multiple autoimmune diseases in wild‐type and B‐cell‐deficient NOD mice

Transient depletion of CD4⁺ CD25⁺ regulatory T cells results in multiple autoimmune diseases in wild‐type and B‐cell‐deficient NOD mice