Selectfluor-Mediated Synthesis of Isoindoline Fused with Triazoles under Metal-Free Conditions

Abstract

An efficient selectfluor-mediated cyclisation of 2-arylethynyl-benzyl azides at 80 °C in MeCN yielded 12 arylated triazoloisoindoline derivatives (seven of which are novel). Products bearing either electron-donating or electron-withdrawing groups on the aromatic ring were formed in comparable yields.