Selected serum acute-phase proteins in peripartum sows and evaluation of their diagnostic usefulness

Wierzchosławski, Karol; Kwit, Krzysztof; Pejsak, Z.; Pomorska‐Mól, Małgorzata

doi:10.1016/j.anireprosci.2018.02.003

Cited by 11 publications

(13 citation statements)

References 37 publications

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“…Similarly, although serum ADA2 tended to differ between PDS + and PDS ÷ sows, this marker appears unsuitable for the use in the diagnosis of PDS. Therefore, ADA in our clinical setting was of lower value in the differentiation between PDS + and PDS ÷ sows as compared to other in ammatory markers, that previously demonstrated their ability to differentiate between these sows [26,28].…”

Section: Discussionmentioning

confidence: 72%

“…The pathogenesis of PDS is insu ciently elucidated, as lined out by Martineau et al [25]. Yet, activation of the stress systems (sympathetic adrenomedullary and hypothalamic adrenocortical axes), oxidative stress, metabolic changes due to low energy intake, and in ammation have been suggested to be involved in the pathogenesis of PDS [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

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Changes of Adenosine Deaminase Activity in Serum and Saliva around Parturition in Sows with and without Postpartum Dysgalactia Syndrome

Kaiser

Dahl

Jacobsen

et al. 2021

Preprint

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BackgroundPostpartum dysgalactia syndrome (PDS) is associated with a significantly higher activation of the inflammatory and stress response at parturition than in the healthy sow. Therefore, reliable and possibly non-invasive biomarkers for substantial increases of inflammation are searched to support the PDS diagnosis. This report studies the possible changes of the inflammatory marker enzyme adenosine deaminase (ADA) in serum and saliva of 38 PDS positive sows (PDS+) and 38 healthy sows (PDS÷). Sampling was performed every 24 h from 60 h before to 36 h after parturition. Isoenzyme 1 (ADA1) and isoenzyme 2 (ADA2), as well as total ADA (tADA) were measured and their statistical association with several serum and saliva biomarkers of inflammation and stress was investigated.ResultsCompared to a baseline (60 h to 36 prepartum), salivary activities of ADA1, ADA2 and tADA increased significantly over time in both PDS+ and PDS÷ sows, reaching their peaks after parturition. In serum from PDS÷ sows, no changes were observed over time in either ADA1, ADA2 or tADA. In PDS+ sows, serum ADA2 activity decreased temporarily after parturition followed by a significant increase compared to baseline. ADA1, ADA2 and tADA were all significantly associated with several inflammatory biomarkers and ADA1 in serum was associated with serum cortisol. Although serum activity was higher in PDS+ than in PDS÷ sows, the differences were not statistically significant. Further, no difference was noted between the groups in the analyses of saliva. Conclusions Salivary ADA1 and ADA2 increased in all sows after parturition, potentially as a response to the postpartum inflammation. However, no difference in the activity of ADA1, ADA2 and tADA were found between PDS+ and PDS÷ sows indicating inability to diagnose PDS under the conditions described in this report.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Changes of Adenosine Deaminase Activity in Serum and Saliva around Parturition in Sows with and without Postpartum Dysgalactia Syndrome

Kaiser

Dahl

Jacobsen

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…The peripartum pattern of CRP concentration that we observed in the bitch is similar to what has been reported for other species, irrespective of different placental types and if they are unitocous or polytocous. An increase of CRP serum concentrations has indeed been detected in sows, where it is evident from the day of parturition until day 7 after farrowing (Wierzchosławski et al, 2018). CRP increased just before delivery (≤2days) in pregnant mares and decreased from 7 days after parturition (Yamashita et al, 1991).…”

Section: Discussionmentioning

confidence: 85%

Evaluation of serum C-reactive protein concentration as a marker of impending parturition and correlation with progesterone profile in peri-partum bitches

Rota¹,

Milani²,

Contiero³

et al. 2019

Animal Reproduction Science

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C-reactive protein (CRP) is one of the major acute phase proteins in dogs; it is produced by the liver and rapidly increases in response to an inflammatory stimulus. The aim of this study was to measure CRP concentrations around parturition and to verify whether this protein could be useful, together with progesterone (P), to detect the end of pregnancy in bitches. CRP and P concentrations were measured on 66 serum samples from 28 healthy pregnant bitches, collected between-5 and +2 days from parturition. The effect of 'days from parturition', parity, and litter size on P and CRP concentration was analyzed. P and CRP values were significantly affected by 'days from parturition'. While P showed the expected decline during the last days of pregnancy, CRP concentration was above the normal range from the day of parturition onwards, beginning to increase at day-1. The CRP concentration profiles during the days around parturition have not been previously reported in the dog. However, the late rise and the low magnitude of increase make CRP difficult to use in clinical practice to assess the end of pregnancy in the bitch.

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“…This indicator should be a molecule, enzyme, or protein that is practical for detection with enzymatic assays or other immunoassay procedures [41]. Recent investigations and data carried over from humans, as well as veterinary medicine, show that acute-phase proteins (APP), microRNAs (miRNAs; short, non-coding RNAs), and cathelicidins measurement may be the tools needed to improve the early diagnostics of ovine mastitis [43][44][45].…”

Section: Promising Novel Inflammatory Markers Of Mastitis In Sheepmentioning

confidence: 99%

“…While CRP (C-reactive protein) is reported not to be an APP in cattle [52] but increases 7-10 times during the acute phase response in the pig [53][54][55]. SAA (serum amyloid A) is an acute-phase protein also in cattle, increasing by over 5 times during the acute phase [43].…”

Section: Acute-phase Proteinsmentioning

confidence: 99%

Potential Novel Biomarkers for Mastitis Diagnosis in Sheep

Libera

Konieczny

Grabska

et al. 2021

Animals

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This review aims to characterize promising novel markers of ovine mastitis. Mastitis is considered as one of the primary factors for premature culling in dairy sheep and has noticeable financial, productional, and animal welfare-related implications. Furthermore, clinical, and subclinical mammary infections negatively affect milk yield and alter the milk composition, thereby leading to lowered quality of dairy products. It is, therefore, crucial to control and prevent mastitis through proper diagnosis, treatment or culling, and appropriate udder health management particularly at the end of the lactation period. The clinical form of mastitis is characterized by abnormalities in milk and mammary gland tissue alteration or systemic symptoms consequently causing minor diagnostic difficulties. However, to identify ewes with subclinical mastitis, laboratory diagnostics is crucial. Mastitis control is primarily dependent on determining somatic cell count (SCC) and the California Mastitis Test (CMT), which aim to detect the quantity of cells in the milk sample. The other useful diagnostic tool is microbial culture, which complements SCC and CMT. However, all mentioned diagnostic methods have their limitations and therefore novel biomarkers of ovine subclinical mastitis are highly desired. These sensitive indicators include acute-phase proteins, miRNA, and cathelicidins measurements, which could be determined in ovine serum and/or milk and in the future may become useful in early mastitis diagnostics as well as a preventive tool. This may contribute to increased detection of ovine mammary gland inflammation in sheep, especially in subclinical form, and consequently improves milk quality and quantity.

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Selected serum acute-phase proteins in peripartum sows and evaluation of their diagnostic usefulness

Cited by 11 publications

References 37 publications

Changes of Adenosine Deaminase Activity in Serum and Saliva around Parturition in Sows with and without Postpartum Dysgalactia Syndrome

Changes of Adenosine Deaminase Activity in Serum and Saliva around Parturition in Sows with and without Postpartum Dysgalactia Syndrome

Evaluation of serum C-reactive protein concentration as a marker of impending parturition and correlation with progesterone profile in peri-partum bitches

Potential Novel Biomarkers for Mastitis Diagnosis in Sheep

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