Selected Risk Factors and Pattern of Semen Abnormality in Male Partners of Infertile Couples in Eastern Nepal: A Descriptive Cross-sectional Study

Pokhrel, Sita; Ghimire, Ashima; Chhetry, Manisha; Lamichane, Sabina; Shreewastav, Rupesh Kumar

doi:10.31729/jnma.4882

Cited by 6 publications

(8 citation statements)

References 7 publications

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“…11.1% in Italy [27], and only 3.2% in a recent study in Germany [28]. The rate of seminal infection in infertile men close to the rate of our study has been reported form Nepal [23,29]. The presence of bacteria in semen in a signi cant number may be an indicator of male accessory gland infection or male genital tract infection [30,31].…”

Section: Discussionsupporting

confidence: 81%

“…Abnormality in semen based on the same seminal characteristics was reported to be 44% [22] and 66.2% [18] from two different hospitals of Nepal, which correlates our study with the semen abnormality trend of other studies among the Nepalese population. The most common characteristic in this study was teratozoopermia as with previous studies [14,23]. However, asthenozoospermia [22,24], and oligozoospermia [16] were also found to be the most common semen characteristics in Nepal.…”

Section: Discussionsupporting

confidence: 77%

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Bacteriospermia in Men Among Infertile Couples in Nepalese Population

Shrestha

Joshi

Vaidya

et al. 2023

Preprint

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Infection of male urogenital tract or male accessory glands is considered as one of the important causes of male infertility, and results in the presence of bacteria in semen affecting fertility potential of men. It is important to know the composition of bacteria in semen to understand the etiology of urogenital infections and its association with infertility. This study aims to know the rate of infection in semen of infertile men, and the association of seminal bacteria with semen parameters related to fertility potential. A cross-sectional study was carried out from June 2021 to July 2022, in which 213 semen samples were collected from the male partners of couples consulting for fertility problems in an infertility center of Nepal. All the samples were processed following WHO guidelines, 2021. Analysis of semen parameters was done immediately after the liquefaction of collected samples. Microbiological assessment was also done for identification of bacteria in semen by conventional method, which showed 25.4% of samples had bacteriospermia. S. aureus and Corynebacterium were predominant bacteria in semen. The volume of semen was significantly associated with bacteriospermia. The concentration of sperms, percentage of total sperm motility, sperms with normal forms and vitality were found to be less in semen with bacteria compared to those without bacteria, which was statistically insignificant. This study provides a baseline data on bacterial infection in semen of infertile men in Nepal.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 77%

Bacteriospermia in Men Among Infertile Couples in Nepalese Population

Shrestha

Joshi

Vaidya

et al. 2023

Preprint

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“…Evaluation and diagnosis for primary infertility in men often begin with semen analysis [ 17 ] especially as certain semen parameters are linked to the functional competence of the sperm cells [ 18 ]. Our findings showed that the herbal formulation caused a significant increase in the sperm count of the experimental rats.…”

Section: Discussionmentioning

confidence: 99%

Toxicological Evaluation of a Polyherbal Formulation on Testicular Function and Gonadal Histomorphology in Exposed Wistar Rats

Udom,

Ise,

Aziakpono

et al. 2023

BioMedicine

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Introduction Dr Iguedo Goko Cleanser® is a herbal formulation (HF) widely marketed in southern Nigeria and purported to be very efficacious for the management of various diseases including giardiasis, toilet infections, hypertension, diabetes, ulcer, impotence, low libido, low sperm count amongst others. Medicinal plants reportedly produce an array of adverse reactions capable of inducing harmful conditions, including death. Aim This study evaluated the subchronic toxicity concern of HF on testicular function and gonadal histoarchitecture in Wistar rats. Methods Thirty Wistar rats of both sexes were randomly divided into six groups (5/group) and were orally administered HF for 60 days. The control groups received 5 mL/kg of distilled water; the treatment groups were administered 476.24 and 158.75 mg/kg body weight of HF each for both male and female rats. Using standard procedures, semen analysis was done for all male rats. Animals were anaesthetised and sacrificed on the 62nd day; the gonads were eviscerated, weighed and fixed in 10% buffered formalin for histopathological examinations. Results Significant (p < 0.05) increase in sperm count relative to control as well as spermatotoxic effects were observed in male rats. Histologically, the ovary presented some degrees of pathologies: cloggy appearing ovarian cortex with a display of a tumour-like cortical area, scantily displayed primordial follicles, haemorrhagic blood vessels, atretic secondary follicle, and eroding granulosa cells amongst others. Testicular histopathology showed abnormal seminiferous tubules’ histoarchitecture, degenerated spermatids, distorted spermatogenic cells’ orientation, and displaced spermatids into the luminal space. Conclusion Herbal drugs are usually regarded to be completely safe due to their natural sources, however, this study discovered exposure-related toxic effects of Dr Iguedo Goko Cleanser® on testicular function and gonadal histomorphology. The findings recommend extreme caution with chronic use and avoidance whenever possible.

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“…This percentage is classified as normal, following the opinion of Kumar and Singh (2015) which states that in most ejaculation the percentage of abnormal spermatozoa ranges from 5-20%. Pokhrel et al (2020) stated that if abnormal spermatozoa are more than 25% of the total spermatozoa in one ejaculation, it will reduce fertility. Meanwhile, according to Rengan et al (2012), spermatozoa abnormalities that exceed 14% indicate the presence of symptoms of infertility or infertility in a male, whereas according to Kumar and Singh (2015), abnormal sperm counts in semen up to 20% will not cause a decrease in fertility rates.…”

Section: Abnormality Of Muscovy Duck Semenmentioning

confidence: 99%

Diluent and Storage Time Effect on Sperm Abnormality and MDA Level in Muscovy Duck Semen at 27oC

Andaruisworo,

Tanjungsari,

Yuniati

et al. 2023

J. Med. Vet.

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This study aimed to determine sperm abnormality and MDA level in Muscovy duck semen in different dilution and storage at 27oC. This study was used in the level of dilution of glutinous semen with a long time store differently at 27oC. In this study, the parameters of the mass motility of spermatozoa were used individual motility, spermatozoa abnormalities, and activity test. A Muscovy duck, healthy and have a high libido were used then divided into treatment groups i.e. (A0) 0; (A1) 5 times; (A2) 10 times; and (A3) 15 times, the second factor as a subplot was the storage time (BO) 0; (B1) 60 minutes; (B2) 120 minutes; and (B3) 180 minutes stored at 27oC with 3 replications. In results, this study was reported abnormalities at a dilution rate in A1 group of 5 times with a shelf life in B1 group of 60 minutes and in B2 group of 120 minutes.

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Selected Risk Factors and Pattern of Semen Abnormality in Male Partners of Infertile Couples in Eastern Nepal: A Descriptive Cross-sectional Study

Cited by 6 publications

References 7 publications

Bacteriospermia in Men Among Infertile Couples in Nepalese Population

Bacteriospermia in Men Among Infertile Couples in Nepalese Population

Toxicological Evaluation of a Polyherbal Formulation on Testicular Function and Gonadal Histomorphology in Exposed Wistar Rats

Diluent and Storage Time Effect on Sperm Abnormality and MDA Level in Muscovy Duck Semen at 27oC

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