Selected pediatric skin tumors: An update for dermatologists

Orlick, Katherine A; Wyatt, Angela J.; Bangert, Jerry L.; Hansen, Ronald C.

doi:10.1067/mdm.2002.121987

Cited by 2 publications

(3 citation statements)

References 130 publications

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“…The average size is 1 cm and it rarely exceeds 2 cm in diameter 19 . Whether PM regress spontaneously is unknown 4 . There are several clinical types of PM: perforating, 3,5,15 bullous, 20,21 melanocytic, 22,23 giant, 7,24 keratoacanthomalike, 15,25 exophytic, 26 anetodermic, 27 lymphangiectatic, 17 multinodular, 18 malignant, 19,28,29 symmetrical involvement 30 and multiple 6,16,30–32 .…”

Section: Discussionmentioning

confidence: 99%

“…3 It has a slight predominance in females, particularly in the younger age group. 4 Perforation is a rare event in this tumor; approximately ten cases of the rare clinical variant, perforating PM, have been reported in the English language published work. 3,5 Pilomatricoma is often confused with other skin lesions, and often the diagnosis is frequently missed preoperatively.…”

Section: Introductionmentioning

confidence: 99%

“…The tumor is common in children, and more than 60% of the cases occur in the first two decades of life 3 . It has a slight predominance in females, particularly in the younger age group 4 . Perforation is a rare event in this tumor; approximately ten cases of the rare clinical variant, perforating PM, have been reported in the English language published work 3,5 …”

Section: Introductionmentioning

confidence: 99%

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A case of perforating pilomatricoma

Çıralık¹,

Çoban

Arıcan

2006

The Journal of Dermatology

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Pilomatricoma is a rare skin neoplasm, most commonly seen in the head and neck region, and occurring in the first two decades of life. It is usually solitary and varies from 0.5 to 2 cm in diameter. Its etiology is unknown. Perforating pilomatricoma is a rare clinical variant that presents as a draining, crusted nodule or ulcer, and is reported to arise faster than the classic pilomatricoma. Herein, we report a case of 35-year-old female, who had a 4-month history of a growing mass on her leg. On physical examination, a 4-cm diameter, asymptomatic, erythematous, ulcerated mass was noted on the left anterio-lateral upper leg. The first histopathological analysis of a punch biopsy from the lesion was reported as basal cell carcinoma. Therefore, the lesion was totally excised. There were shadow cells, squamoid cells, and basaloid aggregations more prominently in the one area in the tumor. In addition, calcification, foreign body giant cells and inflammatory cells were present. Punch or excisional biopsies are preferred as a method of diagnosis for the majority of cutaneous neoplasms. If total excision is not the method of choice, multiple punch biopsies should be made from different areas in large skin tumors for correct diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A case of perforating pilomatricoma

Çıralık¹,

Çoban

Arıcan

2006

The Journal of Dermatology

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YAP immunoreactivity is directly related to pilomatrixoma size and proliferation rate

et al. 2014

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Organ size regulation is a highly coordinated process involving complex mechanisms. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif, also known as WWTR1 (TAZ) have recently been linked to organ size determination and cell proliferation. Pilomatrixoma (PM) is a benign tumor of the adnexal appendages with a certain degree of differentiation toward the matrix of the hair follicle. PM presents as a dermal nodule that usually ranges from 0.5 to 2 cm, rarely exceeding 3 cm. We recently observed a case of unusual "giant" (6.5 cm) PM. Our hypothesis was that YAP and TAZ could be related to PM growth. We analyzed YAP and TAZ immunohistochemical expression in the giant and in ten usual size PMs in relation with tumor size and proliferation rate. YAP nuclear expression was remarkably higher in the giant PM in comparison with usual size PMs and statistically correlated, in a direct manner, with size and proliferation rate of PMs. Contrariwise, TAZ nuclear expression seemed stochastic. Our findings suggest that YAP could play a role in PM growth.

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Selected pediatric skin tumors: An update for dermatologists

Cited by 2 publications

References 130 publications

A case of perforating pilomatricoma

A case of perforating pilomatricoma

YAP immunoreactivity is directly related to pilomatrixoma size and proliferation rate

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