Selected maternal, fetal and placental trace element and heavy metal and maternal vitamin levels in preterm deliveries with or without preterm premature rupture of membranes

Kucukaydin, Zehra; Kurdoğlu, Mertihan; Kurdoğlu, Zehra; Demır, Halit; Yörük, İbrahim

doi:10.1111/jog.13591

Cited by 24 publications

(44 citation statements)

References 52 publications

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“…These results were in line with previous studies [8,30]. Retinol is significantly higher in the sera of mothers giving preterm births as a result of preterm premature rupture of membranes [31]. Thus, preterm premature rupture of membranes could affect vitamin A levels; nonetheless, the exact mechanisms is yet to be comprehensively elucidated.…”

Section: Discussionsupporting

confidence: 91%

The relationship between umbilical cord blood vitamin A levels and late preterm infant morbidities: a prospective cohort study

Tao

Chen

et al. 2020

Eur J Pediatr

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Background: Low plasma vitamin A levels increases the risk of neonates' morbidity. However, the relationship between umbilical cord blood (UCB) vitamin A levels and late-preterm infant (LPI) consequences is inconclusive. Herein, we attempted to clarify the association between UCB vitamin A levels and LPI morbidities. Methods: We conducted a prospective cohort study of 208 LPI (from 34+0 to 36+6 weeks gestational age) between January 1, 2014 and June 30, 2015. UCB specimens were collected shortly after birth, and vitamin A levels were determined by enzyme-linked immunosorbent assay. Jaundice, sepsis, respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, and death were recorded. Results: Prevalence of low UCB vitamin A level <0.7 μmol/L was 37.5% in LPI. Cesarean section was an independent risk factor of UCB vitamin A level < 0.7 μmol/L. Nevertheless, UCB vitamin A levels did not correlate with gestational age, birthweight, and gender. UCB vitamin A level < 0.7 μmol/L was not an independent risk factor for hospitalization, oxygen supplementation, hyperbilirubinemia, sepsis and respiratory distress syndrome. However, cesarean section, gestational age < 35 weeks and birthweight < 2500 g were independent risk factors for hospitalization and RDS. In addition, cesarean section increased the risk of oxygen supplementation, while gestational age < 35 weeks increased the risk of hyperbilirubinemia. Conclusions: Cesarean section delivery is an independent risk factor of low UCB vitamin A levels, and increases the risk of RDS. On the basis of our results, there is no association between low vitamin A levels and morbidity of late-preterm infants, including hyperbilirubinemia, sepsis and respiratory distress syndrome. Trial registration: Not applicable. Background Late-preterm infants (LPI) (with gestational age between 34+0 and 36+6 weeks) is common in preterm infants. LPI has a higher morbidity of apnea, respiratory distress, kernicterus [1], and mortality rates when compared to term infants [2, 3]. Pediatricians are responsible for caring for

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Section: Discussionsupporting

confidence: 91%

The relationship between umbilical cord blood vitamin A levels and late preterm infant morbidities: a prospective cohort study

Tao

Chen

et al. 2020

Eur J Pediatr

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“…The levels of trace elements and heavy metals in blood may differ across different communities and geographic locations, and their effects on pregnant women also vary . Through the vessels that develop in the placenta and fetus, water and/or solute from maternal blood passes across the placenta to the fetus and then to the amniotic fluid; therefore, the composition of amniotic fluid likely reflects the composition of fetal blood .…”

Section: Discussionmentioning

confidence: 99%

Amniotic fluid levels of selected trace elements and heavy metals in pregnancies complicated with neural tube defects

Ovayolu

Ovayolu²,

Karaman

et al. 2019

Congenital Anomalies

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The aims of this study were to determine the levels of trace elements and heavy metals, namely aluminum (Al), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), molybdenum (Mo), cadmium (Cd), tin (Sn), antimony (Sb), mercury (Hg), and lead (Pb), in the amniotic fluid of pregnant women, and to investigate their relationship with neural tube defects (NTDs). The study included 36 pregnant women whose fetuses were complicated with NTDs (study group) and 39 pregnant women with unaffected healthy fetuses (control group), who were matched for body mass index and gestational weeks. The amniotic fluid levels of trace elements and heavy metals were measured using inductively coupled plasma‐mass spectrometry and compared between the two groups. Significantly lower mean levels of Zn and Mo and significantly higher levels of Al, Sn, Sb, and Hg in the study group than in the healthy control group were observed, which implied that these elements are possibly correlated with risk factors for the occurrence of NTDs. In contrast, there were no significant differences in the levels of Cr, Mn, Co, Ni, Cu, As, Cd, and Pb between the groups (P ≥ .05).

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“…In our trial, there was only a reduction in preterm births with intervention without any associated difference in clinically detectable infections between study groups. Potential mechanisms for a preventive effect on PPROM-associated preterm births in our study may include anti-inflammatory effects of myo -inositol ( 38 ) and a contribution from the potential synergistic effect of micronutrients, including zinc and vitamin D ( 39 ). Our results of specifically a reduction in late preterm births is still clinically significant since prematurity survivors in this group constitute the majority of cases of neurodevelopmental disability associated with preterm delivery ( 40 ); thus, the supplement could potentially be impactful.…”

Section: Discussionmentioning

confidence: 97%

Myo-Inositol, Probiotics, and Micronutrient Supplementation From Preconception for Glycemia in Pregnancy: NiPPeR International Multicenter Double-Blind Randomized Controlled Trial

et al. 2021

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Better preconception metabolic and nutritional health are hypothesized to promote gestational normoglycemia and reduce preterm birth, but evidence supporting improved outcomes with nutritional supplementation starting preconception is limited. RESEARCH DESIGN AND METHODSThis double-blind randomized controlled trial recruited from the community 1,729 U.K., Singapore, and New Zealand women aged 18-38 years planning conception. We investigated whether a nutritional formulation containing myo-inositol, probiotics, and multiple micronutrients (intervention), compared with a standard micronutrient supplement (control), taken preconception and throughout pregnancy could improve pregnancy outcomes. The primary outcome was combined fasting, 1-h, and 2-h postload glycemia (28 weeks gestation oral glucose tolerance test). RESULTSBetween 2015 and 2017, participants were randomized to control (n 5 859) or intervention (n 5 870); 585 conceived within 1 year and completed the primary outcome (295 intervention, 290 control). In an intention-to-treat analysis adjusting for site, ethnicity, and preconception glycemia with prespecified P < 0.017 for multiplicity, there were no differences in gestational fasting, 1-h, and 2-h glycemia between groups (b [95% CI] log e mmol/L intervention vs. control 20.

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Selected maternal, fetal and placental trace element and heavy metal and maternal vitamin levels in preterm deliveries with or without preterm premature rupture of membranes

Cited by 24 publications

References 52 publications

The relationship between umbilical cord blood vitamin A levels and late preterm infant morbidities: a prospective cohort study

The relationship between umbilical cord blood vitamin A levels and late preterm infant morbidities: a prospective cohort study

Amniotic fluid levels of selected trace elements and heavy metals in pregnancies complicated with neural tube defects

Myo-Inositol, Probiotics, and Micronutrient Supplementation From Preconception for Glycemia in Pregnancy: NiPPeR International Multicenter Double-Blind Randomized Controlled Trial

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