Selected lines of Aedes aegypti with persistently distorted sex ratios

Owusu-Daaku, K.; Wood, R. J.; Butler, R. D.

doi:10.1038/sj.hdy.6882020

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…The impact of a strong M D gene is also inßuenced by the degree of sensitivity associated with the m s/i locus, because sensitivity varies considerably among Ae. aegypti populations (Hickey and Craig 1966a, Wood 1976, Owusu-Daaku et al 1997, Suguna et al 1977. By determining the molecular basis for the M D phenotype, we may be able to design synthetic gene constructs with enhanced drive potential or to identify other candidate drive genes based on the determination of the exact drive mechanism.…”

Section: Discussionmentioning

confidence: 99%

Reinvestigation of an Endogenous Meiotic Drive System in the Mosquito, <I>Aedes aegypti</I> (Diptera: Culicidae)

Mori

Chadee²,

Graham³

et al. 2004

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We have initiated efforts to determine the molecular basis for the M(D) meiotic drive system in the mosquito, Aedes aegypti. The effect of the M(D) gene is a highly male-biased sex ratio, but varies depending on the frequency and sensitivity of a susceptible responder m(s) allele. The M(D) system has potential as a mechanism for driving trangenes for pathogen resistance into natural Ae. aegypti populations. Because all previously existing laboratory strains carrying the M(D) gene have been lost, we have selected for a new strain, T37, that carries a strong driver. Matings between T37 males and drive-susceptible m(s) females result in progeny with highly biased sex ratios, wherein only approximately 14.7% females are produced. We discuss the potential for identifying M(D) candidate genes based on comparisons with the well-described Drosophila melanogaster segregation distorter (SD) meiotic drive system and considerations for release of transgenic Ae. aegypti into natural populations where M(D) and insensitive m3 alleles are likely segregating.

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Section: Discussionmentioning

confidence: 99%

Reinvestigation of an Endogenous Meiotic Drive System in the Mosquito, <I>Aedes aegypti</I> (Diptera: Culicidae)

Mori

Chadee²,

Graham³

et al. 2004

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“…Deleterious alleles that affect the sexes differentially are known in several species (Lindsley and Zimm 1992;Owusu-Daaku et al 1997;Smith et al 1998;Charlesworth and Dempsey 2001) and are expected to occur in all species. These may lead to sex-ratio distortions with inbreeding.…”

Section: Introductionmentioning

confidence: 99%

Does inbreeding distort sex-ratios?

Frankham

Wilcken

2006

Conserv Genet

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Inbreeding is reputed to distort sex-ratios by reducing the proportion of the homogametic sex. However, many data sets do not show such an effect, and there is a known selective publication bias. To resolve the issue, we (a) developed detailed theoretical expectations for the effects of inbreeding on sex-ratios for autosomal and sex-linked loci with sex-limited effects or with equal effects in the two sexes, (b) evaluated the effects of inbreeding on sex-ratios in a new sample of 25 vertebrate taxa, and (c) evaluated the effects of inbreeding on sex-ratios for 69 replicate populations of Drosophila melanogaster. Theoretical analyses indicated that directional distortions of sex-ratios under inbreeding due to sex-linked loci with sex-limited expression are expected to be small and uncommon and that there will be no distortions in marsupials. Further, sex linked alleles expressed equally in both sexes may also distort sex-ratios following inbreeding. Autosomal sex-limited alleles should not result in directional sex-ratio distortions in large populations or across many replicates, but may lead to distortions of random direction in some small populations. There were no significant directional distortions of sex-ratio due to inbreeding in either the vertebrates or the Drosophila populations. However, there were significant random distortions of sex-ratios in both data sets, presumably from autosomal sex-limited alleles that had drifted in individual populations. Thus, directional distortions in sex-ratio are not a consistent signal of inbreeding depression.

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