Selected Heavy Metals Removal From Electroplating Wastewater by Purified and Polyhydroxylbutyrate Functionalized Carbon Nanotubes Adsorbents

Bankole, M. T.; Abdulkareem, A. S.; Mohammed, Ishaq Alhassan; Ochigbo, Stephen Shaibu; Tijani, Jimoh Oladejo; Abubakre, O. K.; Roos, W.

doi:10.1038/s41598-018-37899-4

Cited by 157 publications

(48 citation statements)

References 47 publications

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“…However, the binding will not occur if there are excessive E. coli endogenous proteins in the supernatant of cell lysate. Moreover, metal ions are banned from human vaccine; thus, columns chelated metal ions are out of our consideration [21]. In the industrial production, cation-exchange chromatography, an inexpensive column with high capacity, is widely used to catch recombinant protein with positive charge from soluble fractions and other endogenous proteins with negative charge will flow through in this column [22].…”

Section: Practical Applicationmentioning

confidence: 99%

Large‐scale production, purification, and function of a tumor multi‐epitope vaccine: Peptibody with bFGF/VEGFA

Zhang

Jiang

Chen

et al. 2020

Engineering in Life Sciences

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In tumor tissue, basic fibroblast growth factor (bFGF) and vascular endothelial growth factor A (VEGFA) promote tumorigenesis by activating angiogenesis, but targeting single factor may produce drug resistance and compensatory angiogenesis. The Peptibody with bFGF/VEGFA was designed to simultaneously blockade these two factors. We were aiming to produce this Fc fusion protein in a large scale. The biological characterizations of Peptibody strains were identified as Escherichia coli and the fermentation mode was optimized in the shake flasks and 10‐L bioreactor. The fermentation was scaled up to 100 L, with wet cell weight (WCW) 126 g/L, production 1.41 g/L, and productivity 0.35 g/(L·h) of IPTG induction. The target protein was isolated by cation‐exchange, hydrophobic and Protein A chromatography, with total recovery of 60.28% and HPLC purity of 86.71%. The host cells protein, DNA, and endotoxin residues were within the threshold. In mouse model, immunization of Peptibody vaccine could significantly suppressed the tumor growth and angiogenesis, with inhibition rate of 57.73 and 39.34%. The Peptibody vaccine could elicit high‐titer anti‐bFGF and anti‐VEGFA antibodies, which inhibited the proliferation and migration of Lewis lung cancer cell cells by decreasing the Akt/MAPK signal pathways. Therefore, the Peptibody with bFGF/VEGFA might be used as a therapeutic tumor vaccine. The large‐scale process we developed could support its industrial production and pre‐clinical study in the future.

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Section: Practical Applicationmentioning

confidence: 99%

Large‐scale production, purification, and function of a tumor multi‐epitope vaccine: Peptibody with bFGF/VEGFA

Zhang

Jiang

Chen

et al. 2020

Engineering in Life Sciences

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“…The peak at 1660cm −1 is correlated with the C=O stretching presence of the carboxylic acid group (–COOH). Vibrational modes associated with MWCNTs are observed at 1445 and 1575 cm −1 , C–C bands must be located at 1377, and C–O bonds of the carboxyl group are obtained at 1010 cm −1 [ 57 , 58 , 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

CVD Conditions for MWCNTs Production and Their Effects on the Optical and Electrical Properties of PPy/MWCNTs, PANI/MWCNTs Nanocomposites by In Situ Electropolymerization

et al. 2021

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In this work, the optimal conditions of synthesizing and purifying carbon nanotubes (CNTs) from ferrocene were selected at the first stage, where decomposition time, argon fluxes, precursor amounts, decomposition temperature (at 1023 K and 1123 K), and purification process (HNO3 + H2SO4 or HCl + H2O2), were modulated through chemical vapor deposition (CVD) and compared to commercial CNTs. The processing temperature at 1123 K and the treatment with HCl + H2O2 were key parameters influencing the purity, crystallinity, stability, and optical/electrical properties of bamboo-like morphology CNTs. Selected multiwalled CNTs (MWCNTs), from 1 to 20 wt%, were electropolymerized through in-situ polarization with conductive polymers (CPs), poly(aniline) (PANI) and poly(pyrrole) (PPy), for obtaining composites. In terms of structural stability and electrical properties, MWCNTs obtained by CVD were found to be better than commercial ones for producing CPs composites. The CNTs addition in both polymeric matrixes was of 6.5 wt%. In both systems, crystallinity degree, related to the alignment of PC chains on MWCNTs surface, was improved. Electrical conductivity, in terms of the carrier density and mobility, was adequately enhanced with CVD CNTs, which were even better than the evaluated commercial CNTs. The findings of this study demonstrate that synergistic effects among the hydrogen bonds, stability, and conductivity are better in PANI/MWCNTs than in PPy/MWCNTs composites, which open a promissory route to prepare materials for different technological applications.

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“…As proved in this study, the polymer functionalization lowered the degree of agglomeration of CNTs, leading to a significant enhancement in the adsorption characteristic of CNTs. e mechanisms of adsorption by this CNT-polymer composite were ion exchange and electrostatic forces [35].…”

Section: For Heavy Metalmentioning

confidence: 99%

Current Advances of Polymer Composites for Water Treatment and Desalination

Berber

2020

Journal of Chemistry

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Over the past five years, a lot of research activities in polymer composites were done in order to improve environmental sustainability and to present advantages for commercial applications of water treatment and desalination. Polymers offered tunable properties, improved processability, remarkable stability, high surface area for fast decontamination, selectivity to eliminate different pollutants, and cost-cutting of water treatment. Hence, the development of polymeric materials is one of the future directions to meet the environmental water standards and to supply the water requirements of the growing populations. This review highlighted the very recent achievements in fabrication, characterization, and applications of polymeric composites used for water treatment and desalination. The polymeric modifications, the addition of functional groups, and the assemblies of nanomaterials were also discussed in detail. In particular, great attention was paid to the recent advances in polymer/polymer composites, polymer/carbon composites, and polymer/clay composites, presenting their usage in the removal of various types of contaminants, e.g., metal ions, dyes, and other toxic pollutants. The review also summarized the main advantages and disadvantages of the different adsorbent materials. Specific attention was paid to the mechanism of adsorption, including chemisorption and physisorption mechanisms. In addition, the challenges and the future perspectives were identified to reach the optimal performance of the different adsorbents.

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Selected Heavy Metals Removal From Electroplating Wastewater by Purified and Polyhydroxylbutyrate Functionalized Carbon Nanotubes Adsorbents

Cited by 157 publications

References 47 publications

Large‐scale production, purification, and function of a tumor multi‐epitope vaccine: Peptibody with bFGF/VEGFA

Large‐scale production, purification, and function of a tumor multi‐epitope vaccine: Peptibody with bFGF/VEGFA

CVD Conditions for MWCNTs Production and Their Effects on the Optical and Electrical Properties of PPy/MWCNTs, PANI/MWCNTs Nanocomposites by In Situ Electropolymerization

Current Advances of Polymer Composites for Water Treatment and Desalination

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