Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis

Sokołowska, Anna; Swierzko, Anna; Szala-Poździej, Agnieszka; Augustynowicz–Kopeć, Ewa; Kozińska, Monika; Niemiec, Tomasz; Błachnio, Maria; Borkowska-Tatar, Dagmara; Jensenius, Jens C.; Thiel, Steffen; Dziadek, Jarosław; Cedzyński, Maciej

doi:10.1016/j.imbio.2020.151905

Cited by 4 publications

(6 citation statements)

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“…level was higher in TB patients when compared with controls, and ficolin-1 might be considered potential marker for the diagnosis of TB, with a high specificity and sensitivity. 27 On the other hand, FCN1 gene polymorphism in multiple diseases had also been studied. Cruyssen et al analyzed the possible association of rheumatoid arthritis and FCN1 gene polymorphism, and found FCN1 rs1071583 G frequency was increased in rheumatoid arthritis patients when compared to controls.…”

Section: Discussionmentioning

confidence: 99%

“…Because ficolin‐1 was secreted by cells crucial for the host response to MTB infection and was thought to play a pivotal role in the first phase of the immune response, many studies had verified the viewpoint that ficolin‐1 was involved in the pathogenesis of PTB 15,27 . Sokołowska et al found that the serum ficolin‐1 level was higher in TB patients when compared with controls, and ficolin‐1 might be considered potential marker for the diagnosis of TB, with a high specificity and sensitivity 27 . On the other hand, FCN1 gene polymorphism in multiple diseases had also been studied.…”

Section: Discussionmentioning

confidence: 99%

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Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population

You

Lin

et al. 2021

Clinical Laboratory Analysis

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The World Health Organisation's (WHO) Global tuberculosis report 2019 shows that approximately 10 million people develop tuberculosis (TB) patients each year. 1 Among these patients, pulmonary TB (PTB) is the most common disease, which is a serious, chronic infectious disease mainly caused by the Mycobacterium tuberculosis (MTB) bacillus. At present, TB remains a major public health problem in the world and is considered to be the main cause of death caused by a single cause and pathogen, because of multi-drug resistant,

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population

You

Lin

et al. 2021

Clinical Laboratory Analysis

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“…Furthermore, investigation of the FCN1 gene −542 G>A polymorphism revealed a higher incidence of G/G homozygosity among patients. The median concentration of MBL in serum was significantly higher in the disease group, despite aforementioned genetic association (94). Similarly, median ficolin-1 level was higher in patients (94), although the FCN1 G allele at position −542 was earlier reported to be associated with the opposite effect (95).…”

Section: Lectin Pathway-associated Molecules In Respiratory Infectionmentioning

confidence: 73%

“…The median concentration of MBL in serum was significantly higher in the disease group, despite aforementioned genetic association (94). Similarly, median ficolin-1 level was higher in patients (94), although the FCN1 G allele at position −542 was earlier reported to be associated with the opposite effect (95). In contrast, ficolin-3 concentrations were generally lower among persons with confirmed infection.…”

Section: Lectin Pathway-associated Molecules In Respiratory Infectionmentioning

confidence: 76%

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The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System

Świerzko

Cedzyński

2020

Front. Immunol.

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Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the associations of factors specific for complement activation via the lectin pathway (LP) with infections of the respiratory system, from birth to adulthood, are discussed. The most extensive data concern mannose-binding lectin (MBL) which together with other collectins (collectin-10, collectin-11) and the ficolins (ficolin-1, ficolin-2, ficolin-3) belong to patternrecognition molecules (PRM) specific for the LP. Those PRM form complexes with MBLassociated serine proteases (MASP-1, MASP-2, MASP-3) and related non-enzymatic factors (MAp19, MAp44). Beside diseases affecting humanity for centuries like tuberculosis or neonatal pneumonia, some recently published data concerning COVID-19 are summarized.

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From simple to complex: Protein‐based biomarker discovery in tuberculosis

Mousavian,

Källenius,

Sundling

2023

Eur J Immunol

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Tuberculosis (TB) is a deadly infectious disease that affects millions of people globally. TB proteomics signature discovery has been a rapidly growing area of research that aims to identify protein biomarkers for the early detection, diagnosis, and treatment monitoring of TB. In this review, we have highlighted recent advances in this field and how it is moving from the study of single proteins to high‐throughput profiling and from only using proteomics to include additional types of data in multi‐omics studies. We have further covered the different sample types and experimental technologies used in TB proteomics signature discovery, focusing on studies of HIV‐negative adults. The published signatures were defined as either coming from hypothesis‐based protein targeting or from unbiased discovery approaches. The methodological approaches influenced the type of proteins identified and were associated with the circulating protein abundance. However, both approaches largely identified proteins involved in similar biological pathways, including acute‐phase responses and T‐helper type 1 and type 17 responses. By analysing the frequency of proteins in the different signatures, we could also highlight potential robust biomarker candidates. Finally, we discuss the potential value of integration of multi‐omics data and the importance of control cohorts and signature validation.This article is protected by copyright. All rights reserved

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Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis

Cited by 4 publications

References 56 publications

Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population

Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population

The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System

From simple to complex: Protein‐based biomarker discovery in tuberculosis

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