Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease

Hezzell, Melanie J; Boswood, Adrian; Moonarmart, Walasinee; Elliott, Jonathan

doi:10.1016/j.jvc.2012.01.009

Cited by 54 publications

(67 citation statements)

References 18 publications

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“…In addition, expression of other matrix metallopeptidases including metallopeptidases with ADAM and ADAMTS domains were significantly altered. Such changes may contribute to LV dilation and remodeling, which has been documented to occur in late-stage DMVD in both humans and dogs (Carabello, 2008;Hezzell et al, 2012;Van De Heyning et al, 2013). While this study provides interesting new data regarding DMVD in dogs, there are some important limitations to this study.…”

Section: Discussionmentioning

confidence: 88%

Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs

Li¹,

Freeman

Rush

et al. 2015

OMICS: A Journal of Integrative Biology

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Canine degenerative mitral valve disease (DMVD) is the most common form of heart disease in dogs. The objective of this study was to identify cellular and metabolic pathways that play a role in DMVD by performing metabolomics and transcriptomics analyses on serum and tissue (mitral valve and left ventricle) samples previously collected from dogs with DMVD or healthy hearts. Gas or liquid chromatography followed by mass spectrophotometry were used to identify metabolites in serum. Transcriptomics analysis of tissue samples was completed using RNA-seq, and selected targets were confirmed by RT-qPCR. Random Forest analysis was used to classify the metabolites that best predicted the presence of DMVD. Results identified 41 known and 13 unknown serum metabolites that were significantly different between healthy and DMVD dogs, representing alterations in fat and glucose energy metabolism, oxidative stress, and other pathways. The three metabolites with the greatest single effect in the Random Forest analysis were γ-glutamylmethionine, oxidized glutathione, and asymmetric dimethylarginine. Transcriptomics analysis identified 812 differentially expressed transcripts in left ventricle samples and 263 in mitral valve samples, representing changes in energy metabolism, antioxidant function, nitric oxide signaling, and extracellular matrix homeostasis pathways. Many of the identified alterations may benefit from nutritional or medical management. Our study provides evidence of the growing importance of integrative approaches in multi-omics research in veterinary and nutritional sciences.

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Section: Discussionmentioning

confidence: 88%

Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs

Li¹,

Freeman

Rush

et al. 2015

OMICS: A Journal of Integrative Biology

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show abstract

“…Another study has shown that key parameters associated with a rapid deterioration of the clinical status were: the LVIDd/Ao and LVIDd/LVFWd and LA/Ao ratios, the mitral E wave amplitude and E/A ratio [30]. Dogs in which the LA/Ao ratio increased by more than 2% per month were more at risk of cardiac death.…”

Section: Quantification Of the Severity Of Mitral Regurgitation (Mr) mentioning

confidence: 99%

“…Dogs in which the LA/Ao ratio increased by more than 2% per month were more at risk of cardiac death. The time to document a 10% increase of the E/A ratio was 4 months in dogs that died due to their heart disease [30].…”

Section: Quantification Of the Severity Of Mitral Regurgitation (Mr) mentioning

confidence: 99%

Assessment and Quantification of Acquired Valvular Regurgitation in Dogs

Madron¹

2015

Clinical Echocardiography of the Dog and Cat

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“…Los daños del aparato valvular y la afección de la contractilidad cardíaca diagnosticada ecográficamente coinciden con estudios anteriores, en los que se indica que la ecocardiografía es el método diagnóstico no invasivo de elección para detectar las lesiones valvulares, en el que podemos evaluar la gravedad de la insuficiencia y, finalmente, también permite evaluar su impacto en la remodelación cardiaca, la función miocárdica, la presión de llenado de los ventrículos y la presión de la arteria pulmonar [9,[21][22][23].…”

Section: Discusión De Resultadosunclassified

Influencia demográfica en la evolución de cardiopatías valvulares con manejo farmacológico y dietario en pacientes caninos de la ciudad de Bucaramanga y su área metropolitana

Gómez

Sánchez²,

Albarracin³

et al. 2013

Spei Domus

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Las enfermedades cardiovasculares se presentan generalmente en perros de avanzada edad (>7 años). Este es el caso de la degeneración valvular mixomatosa (dvm), que es una cardiopatía adquirida cuyo signo característico es la presencia de soplos audibles. El objetivo de esta investigación fue analizar la influencia demográfica sobre la evolución de los pacientes con tratamiento farmacológico y con dietas hiponatrémicas en dvm. Se trabajó con 60 pacientes hasta 15 kg de peso, hembras y machos, enteros o castrados, entre 6 y 15 años de edad, que presentaban la enfermedad en estadio B y C, que requieren medicación y soporte dietario. Se realizó una medición inicial de electrolitos, cuadro hemático, proteínas totales, densidad urinaria, creatinina y pruebas imagenológicas (radiología, ecocardiografía y electrocardiografía); posteriormente se dividieron en tres grupos con 20 pacientes cada uno y fueron medicados farmacológicamente con enalapril y espironolactona combinada (Cardial®) y a cada uno de ellos se les asignó una dieta diferente (dieta mixta y concentrado, Hill’s h/d® y Hill’s k/d®). Según los resultados, los pacientes a los que se les suministró dietas hiponatrémicas presentaron mejor comportamiento clínico y un nivel de sobrevida mayor. Debido a esto, aquellos pacientes cuyos dueños pertenecían a estratos bajos al parecer no tenían la capacidad económica de administrar a sus mascotas estas dietas, lo que repercutió en la salud de ellos, ya que el porcentaje de mortalidad fue alto (90%).

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Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease

Cited by 54 publications

References 18 publications

Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs

Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs

Assessment and Quantification of Acquired Valvular Regurgitation in Dogs

Influencia demográfica en la evolución de cardiopatías valvulares con manejo farmacológico y dietario en pacientes caninos de la ciudad de Bucaramanga y su área metropolitana

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