Selected disease fundamentals based on the unified cell bioenergetics

Kasperski, Andrzej; Kasperska, Renata

doi:10.5455/jib.20130227041230

Cited by 7 publications

(13 citation statements)

References 61 publications

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“…The results presented in this article are based on unified cell bioenergetics (UCB) (Kasperski 2008 ; Kasperski and Kasperska 2013 ). In accordance with UCB, the direct cause of metabolism regulation is positive feedback for ATP (fATP).…”

Section: Methods and Theoretical Basismentioning

confidence: 99%

“…ATP is the performer of metabolic regulation causing fATP, the local negative regulation of glycolysis, and the tricarboxylic acid (TCA) cycle (Krebs cycle). Because mitochondria are charged with NADH during the TCA cycle, and NADH is discharged from mitochondria in the electron transport chain (ETC), disturbances of fATP can change the amount of intramitochondrial high energy molecules (mtNADH and mtFADH 2 ) (Kasperski 2008 ; Kasperski and Kasperska 2013 ).…”

Section: Methods and Theoretical Basismentioning

confidence: 99%

“…According to UCB each cell contains specific mtNADH normal and mtNADH critical levels (where mtNADH critical > mtNADH normal , Fig. 1 ) (Kasperski 2008 ; Kasperski and Kasperska 2013 ). Increase of the intramitochondrial NADH (mtNADH) to a mtNADH critical level causes a gradual inhibition of the TCA cycle; exceeding this level results in full blockage of the TCA cycle.…”

Section: Methods and Theoretical Basismentioning

confidence: 99%

“…Decrease of the mtNADH to the mtNADH normal level causes gradual inhibition of fermentation; exceeding this level causes full fermentation blockage. Moreover, exceeding the mtNADH critical level while decreasing mtNADH, starts and then stimulates the TCA cycle (Kasperski 2008 ; Kasperski and Kasperska 2013 ). An increase of the amount of intramitochondrial high energy molecules (i.e.…”

Section: Methods and Theoretical Basismentioning

confidence: 99%

“…The unified cell bioenergetics (UCB) is an extension of integrated cell bioenergetics and allows for the interpretation of several main cell bioenergetic effects, that can occur during the metabolism of eukaryotic cells, inclusive of Pasteur’s, Crabtree, Kluyver and glucose effects (Kasperski 2008 ; Kasperski and Kasperska 2013 ). According to UCB the occurrence of cellular bioenergetic effects and certain diseases are dependent on the intramitochondrial NAHD level.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Bioenergetics of life, disease and death phenomena

Kasperski

Kasperska

2018

Theory Biosci.

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In this article, some new aspects of unified cell bioenergetics are presented. From the perspective of unified cell bioenergetics certain subsequent stages of cancer development, from initiation stage, through transformation to metastasis, are analyzed. Here we show that after transformation, cancer cells are permanently exposed to reactive oxygen species, that causes continual random DNA mutations and as a result genome and chromosomal destabilizations. The modern cancer attractor hypothesis has been extended in explaining cancer development. Discussion is conducted in light of current cancerogenesis research, including bioenergetic cancer initiation, the somatic mutation theory and the tissue organization field theory. In the article reasons complicating the discovery of patterns of cancer genome changes and cancer evolution are presented. In addition certain cancer therapeutic aspects are given attention to.

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Section: Methods and Theoretical Basismentioning

confidence: 99%

Section: Methods and Theoretical Basismentioning

confidence: 99%

Section: Methods and Theoretical Basismentioning

confidence: 99%

Section: Methods and Theoretical Basismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioenergetics of life, disease and death phenomena

Kasperski

Kasperska

2018

Theory Biosci.

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The Digital World of Cytogenetic and Cytogenomic Web Resources

Kasperski,

Heng

2024

Methods in Molecular Biology

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Study on attractors during organism evolution

Kasperski

Kasperska

2021

Sci Rep

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The important question that arises during determining the evolution of organisms is whether evolution should be treated as a continuous process or whether groups of organisms fall into 'local' attractors during evolution. A similar question arises during considering the development of cells after cancer transformation. Answers to these questions can provide a better understanding of how normal and transformed organisms evolve. So far, no satisfactory answers have been found to these questions. To find the answers and demonstrate that organisms during evolution get trapped in 'local' attractors, an artificial neural network supported by a semihomologous approach and unified cell bioenergetics concept have been used in this work. A new universal model of cancer transformation and cancer development has been established and presented to highlight the differences between the development of transformed cells and normal organisms. An unequivocal explanation of cancer initialization and development has not been discovered so far, thus the proposed model should shed new light on the evolution of transformed cells.

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Selected disease fundamentals based on the unified cell bioenergetics

Cited by 7 publications

References 61 publications

Bioenergetics of life, disease and death phenomena

Bioenergetics of life, disease and death phenomena

The Digital World of Cytogenetic and Cytogenomic Web Resources

Study on attractors during organism evolution

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