Selected application of peptide molecules as pharmaceutical agents and in cosmeceuticals

Negahdaripour, Manica; Owji, Hajar; Eslami, Mahboobeh; Zamani, Mozhdeh; Vakili, Bahareh; Sabetian, Soudabeh; Nezafat, Navid; Ghasemi, Younes

doi:10.1080/14712598.2019.1652592

Cited by 17 publications

(9 citation statements)

References 127 publications

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“…Peptide-based cosmeceuticals acting against both intrinsic and extrinsic aging and improving the health and appearance of skin are becoming increasingly popular. Bioactive peptides have either pharmaceutical or cosmetic value and open a new avenue in the field of gerocosmetology [380,381]. They are used for collagen stimulation, wound healing, "botox-like" wrinkle smoothing, as well as antioxidative, antimicrobial, and whitening effects [378].…”

Section: Peptide-based Cosmeceuticalsmentioning

confidence: 99%

A Global Review on Short Peptides: Frontiers and Perspectives

et al. 2021

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Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.

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Section: Peptide-based Cosmeceuticalsmentioning

confidence: 99%

A Global Review on Short Peptides: Frontiers and Perspectives

et al. 2021

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“…As was mentioned above, peptide synthesis continues to be one of the areas of greatest interest in organic chemistry. This is due to the fact that peptides have many diverse applications, not only in the synthesis of organic compounds, but most importantly in the food and pharmaceutical industry [ 110 , 111 , 112 ]. In this regard, in recent years mechanochemistry has played an important role in the green synthesis of these compounds [ 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ].…”

Section: Mechanochemistrymentioning

confidence: 99%

Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions

Avila‐Ortiz

Juaristi

2020

Molecules

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One central challenge for XXI century chemists is the development of sustainable processes that do not represent a risk either to humanity or to the environment. In this regard, the search for more efficient and clean alternatives to achieve the chemical activation of molecules involved in chemical transformations has played a prominent role in recent years. The use of microwave or UV-Vis light irradiation, and mechanochemical activation is already widespread in many laboratories. Nevertheless, an additional condition to achieve “green” processes comes from the point of view of so-called atom economy. The removal of solvents from chemical reactions generally leads to cleaner, more efficient and more economical processes. This review presents several illustrative applications of the use of sustainable protocols in the synthesis of organic compounds under solvent-free reaction conditions.

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“…Defensins are arginine-rich antimicrobial peptides, which can hypothetically inhibit furin since it was proven that poly-arginine-derived molecules could inhibit the activity of furin protein [ 17 ]. Plants, animals, and fungi express defensins as a defense tool [ 18 , 19 ], regarded as essential for the host response to infections. Defensins have antimicrobial effects against Gram-positive and Gram-negative bacteria, fungi, parasitic protozoa, and enveloped and nonenveloped viruses [ 18 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design

Negahdaripour

Rahbar

Mosalanejad

et al. 2022

Computational and Mathematical Methods in Medicine

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Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was characterized as a pandemic by the World Health Organization (WHO) in Dec. 2019. SARS-CoV-2 binds to the cell membrane through spike proteins on its surface and infects the cell. Furin, a host-cell enzyme, possesses a binding site for the spike protein. Thus, molecules that block furin could potentially be a therapeutic solution. Defensins are antimicrobial peptides that can hypothetically inhibit furin because of their arginine-rich structure. Theta-defensins, a subclass of defensins, have attracted attention as drug candidates due to their small size, unique structure, and involvement in several defense mechanisms. Theta-defensins could be a potential treatment for COVID-19 through furin inhibition and an anti-inflammatory mechanism. Note that inflammatory events are a significant and deadly condition that could happen at the later stages of COVID-19 infection. Here, the potential of theta-defensins against SARS-CoV-2 infection was investigated through in silico approaches. Based on docking analysis results, theta-defensins can function as furin inhibitors. Additionally, a novel candidate peptide against COVID-19 with optimal properties regarding antigenicity, stability, electrostatic potential, and binding strength was proposed. Further in vitro/in vivo investigations could verify the efficiency of the designed novel peptide.

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Selected application of peptide molecules as pharmaceutical agents and in cosmeceuticals

Cited by 17 publications

References 127 publications

A Global Review on Short Peptides: Frontiers and Perspectives

A Global Review on Short Peptides: Frontiers and Perspectives

Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions

Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design

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